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1000279-69-5,MFCD16495814
Catalog No.:AA00008Z

1000279-69-5 | A-867744

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$154.00   $108.00
- +
10mg
≥98%
in stock  
$173.00   $121.00
- +
50mg
≥98%
in stock  
$688.00   $481.00
- +
100mg
≥98%
in stock  
$1,119.00   $783.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00008Z
Chemical Name:
A-867744
CAS Number:
1000279-69-5
Molecular Formula:
C20H19ClN2O3S
Molecular Weight:
402.8945
MDL Number:
MFCD16495814
SMILES:
CCC(=O)c1cc(n(c1C)c1ccc(cc1)S(=O)(=O)N)c1ccc(cc1)Cl
Properties
Computed Properties
 
Complexity:
620  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3.7  

Literature

Title: Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells.

Journal: Neurochemistry international 20101001

Title: In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.

Journal: The Journal of pharmacology and experimental therapeutics 20100901

Title: Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.

Journal: British journal of pharmacology 20091201

Title: In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.

Journal: The Journal of pharmacology and experimental therapeutics 20090701

Title: Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.

Journal: Journal of medicinal chemistry 20090528

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