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1000669-72-6,MFCD18385006
Catalog No.:AA0000Q5

1000669-72-6 | Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-

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5mg
≥98%
in stock  
$50.00   $35.00
- +
10mg
≥98%
in stock  
$96.00   $67.00
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25mg
≥98%
in stock  
$213.00   $149.00
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50mg
≥98%
in stock  
$376.00   $263.00
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200mg
in stock  
$1,325.00   $928.00
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500mg
98% by HPLC
in stock  
$2,920.00   $2,044.00
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1000mg
98% by HPLC
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0000Q5
Chemical Name:
Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-
CAS Number:
1000669-72-6
Molecular Formula:
C20H20N4O
Molecular Weight:
332.3990
MDL Number:
MFCD18385006
SMILES:
O=C(c1ccc(cc1)C=Cc1n[nH]c2c1cccc2)N1CCNCC1
Properties
Computed Properties
 
Complexity:
480  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.7  

Literature

Title: Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Journal: Journal of medicinal chemistry 20131024

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110515

Title: FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo.

Journal: Blood 20110324

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: [FLT3 kinase inhibitors for the treatment of acute leukemia].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20100601

Title: FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.

Journal: Blood 20100218

Title: KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.

Journal: Blood 20090820

Title: Shiotsu Y, et al. KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114(8):1607-17.

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Tags:1000669-72-6 Molecular Formula|1000669-72-6 MDL|1000669-72-6 SMILES|1000669-72-6 Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-