Name: Name:GDC-0068
Brand: AABLOCKS
SKU: AA0000XK
Rating: 90 (10 reviews)

Catalog No.:AA0000XK

1001264-89-6 | GDC-0068

Pack Size

Purity

Availability

Price(USD)

Quantity

5mg

98+%

in stock

$53.00 $37.00

- +

10mg

98+%

in stock

$79.00 $55.00

- +

100mg

99.88%

in stock

$693.00 $485.00

- +

200mg

99.88%

in stock

$1,122.00 $785.00

- +

500mg

99.88%

in stock

$2,193.00 $1,535.00

- +

99.88%

in stock

$3,765.00 $2,635.00

- +

Technical Information
Properties
Literature
Request for Quotation
Q & A

Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA0000XK

Chemical Name:

GDC-0068

CAS Number:

1001264-89-6

Molecular Formula:

C24H32ClN5O2

Molecular Weight:

457.9962

MDL Number:

MFCD22124514

IUPAC Name:

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

InChI:

InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1

InChI Key:

GRZXWCHAXNAUHY-NSISKUIASA-N

SMILES:

CC(NC[[email protected]@H](C(=O)N1CCN(CC1)c1ncnc2c1[[email protected]](C)C[[email protected]]2O)c1ccc(cc1)Cl)C

UNII:

524Y3IB4HQ

Properties

Computed Properties

Complexity:

622

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

457.224g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

458.003g/mol

Monoisotopic Mass:

457.224g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

81.6A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

2.5

Synonyms

2-(4-chlorophenyl)-1-(4-(7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one

GDC-0068

GDC-0068 (RG7440)

524Y3IB4HQ

(S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one

CHEMBL2177390

(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone

RG-7440

C24H32ClN5O2

(2s)-2-(4-Chlorophenyl)-1-{4-[(5r,7r)-7-Hydroxy-5-Methyl-6,7-Dihydro-5h-Cyclopenta[d]pyrimidin-4-Yl]piperazin-1-Yl}-3-(Propan-2-Ylamino)propan-1-One

1-Propanone, 2-(4-chlorophenyl)-1-(4-((5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl)-1-piperazinyl)-3-((1-methylethyl)amino)-, (2S)-

Ipatasertib [USAN:INN]

GDC0068

1-Propanone, 2-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-, (2S)-

AK174371

RG 7440

Ipatasertib (USAN/INN)

Ipatasertib; GDC-0068

SCHEMBL191659

GTPL7887

CHEBI:95089

GRZXWCHAXNAUHY-NSISKUIASA-N

AOB87386

Ipatasertib

EX-A2077

BDBM50398379

MFCD22124514

s2808

ZINC68250459

AKOS025396463

BCP9000712

CS-0975

DB11743

SB16560

GDC-0068

NCGC00346714-01

(2S)-2-(4-Chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl(-3-((propan-2-yl)amino)propan-1-one

AC-28420

AS-17027

BC295592

HY-15186

QC-10488

BCP0726000195

AB0033076

FT-0773211

1001264-89-6

X6541

J3.478.537F

D10641

W-5890

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[e]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

0RF

AKT inhibitors

Ipatasertib [INN]

D0I4TH

cc-616

Ipatasertib (GDC-0068)

A3006

A11246

1417449-25-2

GDC 0068

UNII-524Y3IB4HQ

RG7440

Literature

Title: Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

Journal: Journal of medicinal chemistry 20120927

Quotation Request

Q & A