Home Pyridines 100299-08-9
100299-08-9,MFCD22575284
Catalog No.:AA0001EJ

100299-08-9 | 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1)

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10mg
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25mg
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$9.00   $7.00
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50mg
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$16.00   $11.00
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250mg
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$28.00   $20.00
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1g
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5g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0001EJ
Chemical Name:
4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1)
CAS Number:
100299-08-9
Molecular Formula:
C10H8KN6O
Molecular Weight:
267.3084
MDL Number:
MFCD22575284
SMILES:
Cc1cccn2c1ncc(c2=O)c1n[nH]nn1.[K]
Properties
Properties
 
BP:
454.8°C at 760 mmHg  
Form:
Solid  
MP:
>280°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
495  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
1  

Literature

Title: Pemirolast reduces cisplatin-induced kaolin intake in rats.

Journal: European journal of pharmacology 20110701

Title: [Toxicity of topical ocular anti-allergic agents on human corneal epithelial cells in vitro].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20100101

Title: Suppressive activity of pemirolast potassium, an antiallergic drug, on glomerulonephritis. Studies in glomerulonephritis model rats and in patients with chronic glomerulonephritis concurrently affected by allergic rhinitis.

Journal: Arzneimittel-Forschung 20080101

Title: The effect of a combined therapy with a histamine H1 antagonist and a chemical mediator release inhibitor on allergic conjunctivitis.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20080101

Title: A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.

Journal: Journal of pharmacological sciences 20060801

Title: Prophylactic effect of pemirolast, an antiallergic agent, against hypersensitivity reactions to paclitaxel in patients with ovarian cancer.

Journal: International journal of cancer 20060515

Title: Tetrazole compounds: the effect of structure and pH on Caco-2 cell permeability.

Journal: Journal of pharmaceutical sciences 20060401

Title: Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis.

Journal: Cornea 20060401

Title: Comparison of antigen-induced leukotriene and histamine release from nasal scrapings in allergic rhinitis.

Journal: Rhinology 20050901

Title: Increasing effect by simultaneous use of levocabastine and pemirolast on experimental allergic conjunctivitis in rats.

Journal: Biological & pharmaceutical bulletin 20050301

Title: Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats.

Journal: Neuropharmacology 20040501

Title: A comparative trial of the safety and efficacy of 0.1 percent pemirolast potassium ophthalmic solution dosed twice or four times a day in patients with seasonal allergic conjunctivitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040401

Title: Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis.

Journal: Japanese journal of ophthalmology 20040101

Title: Preventive effect of an antiallergic drug, pemirolast potassium, on restenosis after stent placement: quantitative coronary angiography and intravascular ultrasound studies.

Journal: Journal of cardiology 20030701

Title: A combined analysis of two studies assessing the ocular comfort of antiallergy ophthalmic agents.

Journal: Clinical therapeutics 20030401

Title: Two mast cell stabilizers, pemirolast potassium 0.1% and nedocromil sodium 2%, in the treatment of seasonal allergic conjunctivitis: a comparative study.

Journal: Advances in therapy 20030101

Title: Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20021001

Title: Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cells.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19971201

Title: A pilot study of pemirolast in patients with seasonal allergic rhinitis.

Journal: Annals of allergy 19910201

Title: Kemp, J.P., et al., Pemirolast, a new oral nonbronchodilator drug for chronic asthma. Ann Allergy, 1992. 68(6): p. 488-91.

Title: Tatsushima, Y., et al., Pemirolast reduces cisplatin-induced kaolin intake in rats. Eur J Pharmacol, 2011. 661(1-3): p. 57-62.

Title: Itoh, Y., et al., Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. Neuropharmacology, 2004. 46(6): p. 888-94.

Title: Abelson, M.B., et al., Pemirolast potassium 0.1% ophthalmic solution is an effective treatment for allergic conjunctivitis: a pooled analysis of two prospective, randomized, double-masked, placebo-controlled, phase III studies. J Ocul Pharmacol Ther, 2002. 18(5): p. 475-88.

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Tags:100299-08-9 Molecular Formula|100299-08-9 MDL|100299-08-9 SMILES|100299-08-9 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1)