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Title: Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats.

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Title: Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass.

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Title: Extrinsic factors involved in the differentiation of stem cells into insulin-producing cells: an overview.

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Title: Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity.

Journal: PloS one 20110101

Title: Acute respiratory distress syndrome: A clinical review.

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Title: Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation.

Journal: Journal of transplantation 20110101

Title: Targeting ceramide synthesis to reverse insulin resistance.

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Title: Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.

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Title: Bioanalysis of pentoxifylline and related metabolites in plasma samples through LC-MS/MS.

Journal: Biomedical chromatography : BMC 20100601

Title: 12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets.

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Title: Pharmacokinetic interaction between verapamil and methylxanthine derivatives in mice.

Journal: Drug metabolism letters 20100101

Title: Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide.

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Title: Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials.

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Title: In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes.

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Title: Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.

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Title: The effects of pentoxifylline on skeletal muscle contractility and neuromuscular transmission during hypoxia.

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Title: Point: steady progress and current challenges in clinical islet transplantation.

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Title: Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock.

Journal: International immunopharmacology 20090401

Title: Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.

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Title: Validation of a high-performance liquid chromatography method for pharmacokinetic evaluation of pentoxifylline and lisofylline in rat serum and tissues.

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Title: Overexpression of thioredoxin in islets transduced by a lentiviral vector prolongs graft survival in autoimmune diabetic NOD mice.

Journal: Journal of biomedical science 20090101

Title: Effects of pentoxifylline and its metabolites on platelet aggregation in whole blood from healthy humans.

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Title: Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung injury.

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Title: Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury.

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Title: Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle.

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Title: Enantioselective reduction of pentoxifylline to lisofylline using whole-cell Lactobacillus kefiri biotransformation.

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Title: Pharmacokinetic modelling of pentoxifylline and lisofylline after oral and intravenous administration in mice.

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Title: Pharmacokinetics of intranasal and intratracheal pentoxifylline in rabbits.

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Title: Prediction of death and prolonged mechanical ventilation in acute lung injury.

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Title: Enantioselective biotransformation of pentoxifylline into lisofylline using wine yeast biocatalysis.

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Title: Intestinal mucosal dysfunction and infection during remission-induction therapy for acute myeloid leukaemia.

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Title: Interconversion and tissue distribution of pentoxifylline and lisofylline in mice.

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Title: Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes.

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Title: Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes.

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Title: Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome.

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Title: Survival methods, including those using competing risk analysis, are not appropriate for intensive care unit outcome studies.

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Title: Bench-to-bedside review: the role of glycosaminoglycans in respiratory disease.

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Title: Multidose streptozotocin induction of diabetes in BALB/c mice induces a dominant oxidative macrophage and a conversion of TH1 to TH2 phenotypes during disease progression.

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Title: Use of liquid chromatography-tandem mass spectrometry for the analysis of pentoxifylline and lisofylline in plasma.

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Title: Inflammatory blockade improves human pancreatic islet function and viability.

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Title: Lisofylline: a potential lead for the treatment of diabetes.

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Title: Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments.

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Title: Pentoxifylline inhibits agonist-induced vasoconstriction in vascular smooth muscle and spontaneous peristalsis in isolated ileum.

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Title: Inflammation blockade improves pancreatic islet function.

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Title: Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury.

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Title: Lisofylline, a novel anti-inflammatory agent, enhances glucose-stimulated insulin secretion in vivo and in vitro: studies in prediabetic and normal rats.

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Title: The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation.

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Title: Lisofylline, a novel antiinflammatory compound, protects mesangial cells from hyperglycemia- and angiotensin II-mediated extracellular matrix deposition.

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Title: Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes.

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Title: The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice.

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Title: Developmental differences in the role of interleukins in hyperoxic lung injury in animal models.

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Title: Lisofylline, a novel antiinflammatory agent, protects pancreatic beta-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism.

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Title: Modulation of gastrointestinal wound repair and inflammation by phospholipids.

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Title: Effects of heparin and lisofylline on pulmonary function after smoke inhalation injury in an ovine model.

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Title: Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome.

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Title: Lisofylline: anti-acute respiratory distress syndrome or just anti-inflammatory?

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Title: Lisofylline and lysophospholipids ameliorate experimental colitis in rats.

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Title: Understanding the roles of the transcription factors nuclear factor-kappaB and hypoxia-inducible factor-1alpha in lung injury.

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Title: Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-kappaB.

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Title: Antioxidant and radical scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline.

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Title: Immunotherapy of inflammatory demyelinating diseases of the central nervous system.

Journal: Immunologic research 20010101

Title: CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo.

Journal: Shock (Augusta, Ga.) 19940401