Home Other Building Blocks 1009298-59-2
1009298-59-2,MFCD22628784
Catalog No.:AA00035A

1009298-59-2 | Azd2014

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$13.00   $9.00
- +
5mg
98+%
in stock  
$61.00   $43.00
- +
10mg
98+%
in stock  
$120.00   $84.00
- +
50mg
95%
in stock  
$386.00   $270.00
- +
100mg
95%
in stock  
$522.00   $365.00
- +
250mg
95%
in stock  
$839.00   $588.00
- +
1g
95%
in stock  
$2,030.00   $1,421.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00035A
Chemical Name:
Azd2014
CAS Number:
1009298-59-2
Molecular Formula:
C25H30N6O3
Molecular Weight:
462.5441
MDL Number:
MFCD22628784
SMILES:
CNC(=O)c1cccc(c1)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)N1CCOC[C@@H]1C
Properties
Properties
 
Form:
Solid  
MP:
233-237ºC  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
698  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.8  

Downstream Synthesis Route
1009298-75-2   
CASUnavailable 
  1009298-59-2 

[1]CurrentPatentAssignee:ShanghaiInstituteofMateriaMedica(in:CAS);CHINESEACADEMYOFSCIENCES;LUOXINPHARMACEUTICALSGROUPSTOCKCOLTD-US2018/79749,2018,A1Locationinpatent:Paragraph0178-0188

[1]CurrentPatentAssignee:ShanghaiInstituteofMateriaMedica(in:CAS);CHINESEACADEMYOFSCIENCES;LUOXINPHARMACEUTICALSGROUPSTOCKCOLTD-US2018/79749,2018,A1

[2]Shen,Guobing;Liu,Miaoqing;Lu,Jianjun;Meng,Tao[TetrahedronLetters,2019,vol.60,#52]

21860-07-1   
AZD2014 

[1]Patent:US2018/79749,2018,A1

[2]TetrahedronLetters,2019,vol.60

[1]CurrentPatentAssignee:ShanghaiInstituteofMateriaMedica(in:CAS);CHINESEACADEMYOFSCIENCES;LUOXINPHARMACEUTICALSGROUPSTOCKCOLTD-US2018/79749,2018,A1

[2]Shen,Guobing;Liu,Miaoqing;Lu,Jianjun;Meng,Tao[TetrahedronLetters,2019,vol.60,#52]

Literature

Title: Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20180901

Title: Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models.

Journal: Oncotarget 20171226

Title: mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection.

Journal: Virology 20140301

Title: Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.

Journal: Bioorganic & medicinal chemistry letters 20130301

Title: TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Journal: Cell metabolism 20120502

Title: Mammalian autophagy: core molecular machinery and signaling regulation.

Journal: Current opinion in cell biology 20100401

Title: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Journal: Nature 20090716

Title: Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Journal: Current biology : CB 20040727

Title: Regulation of longevity and stress resistance by Sch9 in yeast.

Journal: Science (New York, N.Y.) 20010413

Title: Guichard SM, et al. AZD2014, an inhibitor of mTORC1 and mTORC2, is highly effective in ER+ breast cancer when administered using intermittent or continuous schedules. Mol Cancer Ther. 2015 Nov;14(11):2508-18.

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