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1011301-29-3,MFCD28099814
Catalog No.:AA008TH5

1011301-29-3 | Tenovin 6 Hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$230.00   $161.00
- +
5mg
≥95%
in stock  
$1,025.00   $717.00
- +
10mg
≥95%
in stock  
$1,818.00   $1,272.00
- +
25mg
≥95%
in stock  
$3,972.00   $2,780.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TH5
Chemical Name:
Tenovin 6 Hydrochloride
CAS Number:
1011301-29-3
Molecular Formula:
C25H35ClN4O2S
Molecular Weight:
491.0890
MDL Number:
MFCD28099814
SMILES:
CN(CCCCC(=O)Nc1ccc(cc1)NC(=S)NC(=O)c1ccc(cc1)C(C)(C)C)C.Cl
Properties
Computed Properties
 
Complexity:
616  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  

Literature

Title: Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.

Title: Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8 J Biol Chem. 2020;jbc.RA119.012056.

Title: Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622.

Title: Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608.

Title: Yuan H, et al. Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget. 2017 Feb 28;8(9):14912-14924.

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SDS
Tags:1011301-29-3 Molecular Formula|1011301-29-3 MDL|1011301-29-3 SMILES|1011301-29-3 Tenovin 6 Hydrochloride