Home Other Building Blocks 1011557-82-6
1011557-82-6,MFCD11976906
Catalog No.:AA0003RW

1011557-82-6 | Tenovin-6

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1mg
≥98%
in stock  
$95.00   $67.00
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5mg
≥98%
in stock  
$213.00   $149.00
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10mg
≥98%
in stock  
$250.00   $175.00
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25mg
≥98%
in stock  
$493.00   $345.00
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50mg
≥98%
in stock  
$620.00   $434.00
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1000mg
98% by HPLC
in stock  
$11,279.00   $7,896.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0003RW
Chemical Name:
Tenovin-6
CAS Number:
1011557-82-6
Molecular Formula:
C25H34N4O2S
Molecular Weight:
454.6281
MDL Number:
MFCD11976906
SMILES:
CN(CCCCC(=O)Nc1ccc(cc1)NC(=S)NC(=O)c1ccc(cc1)C(C)(C)C)C
Properties
Computed Properties
 
Complexity:
616  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
5.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:UNIVERSITYOFDUNDEE;UNIVERSITYOFSTANDREWS-WO2008/29096,2008,A2Locationinpatent:Page/Pagecolumn23-24;36-37

[1]CurrentPatentAssignee:UNIVERSITYOFDUNDEE;UNIVERSITYOFSTANDREWS-WO2008/29096,2008,A2Locationinpatent:Page/Pagecolumn23-24;36-37

Literature

Title: An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells.

Journal: Cell cycle (Georgetown, Tex.) 20120501

Title: Identification and characterization of novel sirtuin inhibitor scaffolds.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.

Title: Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8 J Biol Chem. 2020;jbc.RA119.012056.

Title: Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622.

Title: Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608.

Title: Yuan H, et al. Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy. Oncotarget. 2017 Feb 28;8(9):14912-14924.

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SDS
Tags:1011557-82-6 Molecular Formula|1011557-82-6 MDL|1011557-82-6 SMILES|1011557-82-6 Tenovin-6