Home Amines 1014691-61-2
1014691-61-2,MFCD12828770
Catalog No.:AA0004GI

1014691-61-2 | 2-Thiophenecarboxylic acid, 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-, methyl ester

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1mg
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$30.00   $21.00
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5mg
98%
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$75.00   $53.00
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10mg
95%
in stock  
$109.00   $76.00
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25mg
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$140.00   $98.00
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50mg
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$176.00   $123.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0004GI
Chemical Name:
2-Thiophenecarboxylic acid, 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-, methyl ester
CAS Number:
1014691-61-2
Molecular Formula:
C19H18N2O5S2
Molecular Weight:
418.4866
MDL Number:
MFCD12828770
SMILES:
COC(=O)c1sccc1S(=O)(=O)Nc1ccc(cc1OC)Nc1ccccc1
Properties
Properties
 
Form:
Solid  
Solubility:
DMSO: soluble10mg/mL, clear  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
618  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
3.8  

Downstream Synthesis Route
C15H15N3O3 
  1014691-61-2 

[1]Mao,Jian-Hui;Wang,Yong-Bin;Yang,Limin;Xiang,Shao-Hua;Wu,Quan-Hao;Cui,Yuan;Lu,Qian;Lv,Jie;Li,Shaoyu;Tan,Bin[NatureChemistry,2021,vol.13,#10,p.982-991]

[1]Mao,Jian-Hui;Wang,Yong-Bin;Yang,Limin;Xiang,Shao-Hua;Wu,Quan-Hao;Cui,Yuan;Lu,Qian;Lv,Jie;Li,Shaoyu;Tan,Bin[NatureChemistry,2021,vol.13,#10,p.982-991]

[1]Mao,Jian-Hui;Wang,Yong-Bin;Yang,Limin;Xiang,Shao-Hua;Wu,Quan-Hao;Cui,Yuan;Lu,Qian;Lv,Jie;Li,Shaoyu;Tan,Bin[NatureChemistry,2021,vol.13,#10,p.982-991]

C9H10N2O3 
  1014691-61-2 

[1]Mao,Jian-Hui;Wang,Yong-Bin;Yang,Limin;Xiang,Shao-Hua;Wu,Quan-Hao;Cui,Yuan;Lu,Qian;Lv,Jie;Li,Shaoyu;Tan,Bin[NatureChemistry,2021,vol.13,#10,p.982-991]

Literature

Title: Perfluorooctanoate suppresses spheroid attachment on endometrial epithelial cells through peroxisome proliferator-activated receptor alpha and down-regulation of Wnt signaling.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20131201

Title: Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.

Journal: Bioorganic & medicinal chemistry letters 20130901

Title: Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.

Journal: The Journal of biological chemistry 20121102

Title: (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties.

Journal: Journal of medicinal chemistry 20120322

Title: Development of improved PPARβ/δ inhibitors.

Journal: ChemMedChem 20120102

Title: Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo.

Journal: PloS one 20120101

Title: High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties.

Journal: Molecular pharmacology 20111101

Title: Administration of PPARβ/δ agonist reduces copper-induced liver damage in mice: possible implications in clinical practice.

Journal: Journal of clinical biochemistry and nutrition 20110701

Title: Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation.

Journal: Acta pharmacologica Sinica 20110501

Title: The decreased expression of peroxisome proliferator-activated receptors delta (PPARdelta) is reversed by digoxin in the heart of diabetic rats.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100801

Title: Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury.

Journal: The Journal of pharmacology and experimental therapeutics 20100501

Title: Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.

Journal: Endocrinology 20100401

Title: Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.

Journal: Journal of medicinal chemistry 20100225

Title: Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20100201

Title: Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.

Journal: Molecular endocrinology (Baltimore, Md.)

Title: Shearer BG, et al. Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Mol Endocrinol. 2008 Feb;22(2):523-9. Epub 2007 Nov 1.

Title: Zhong X, et al. Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation. Acta Pharmacol Sin. 2011 May;32(5):591-600.

Title: Lee WJ, et al. Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide-triggered glutamate release in BV-2 microglial cells. J Cell Biochem. 2018 Feb 1.

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SDS
Tags:1014691-61-2 Molecular Formula|1014691-61-2 MDL|1014691-61-2 SMILES|1014691-61-2 2-Thiophenecarboxylic acid, 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-, methyl ester