Home Other Building Blocks 101477-54-7
101477-54-7,MFCD01703867
Catalog No.:AA0004I3

101477-54-7 | Lomerizine hydrochloride

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100mg
≥98%
in stock  
$48.00   $33.00
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250mg
≥98%
in stock  
$98.00   $68.00
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500mg
≥98%
in stock  
$152.00   $106.00
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1g
≥ 98.5% (Assay on dry basis)
in stock  
$222.00   $155.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0004I3
Chemical Name:
Lomerizine hydrochloride
CAS Number:
101477-54-7
Molecular Formula:
C27H32Cl2F2N2O3
Molecular Weight:
541.4574
MDL Number:
MFCD01703867
SMILES:
COc1c(ccc(c1OC)OC)CN1CCN(CC1)C(c1ccc(cc1)F)c1ccc(cc1)F.Cl.Cl
Properties
Computed Properties
 
Complexity:
568  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Changes in optic nerve head circulation in response to vasoactive agents: intereye comparison in monkeys with experimental unilateral glaucoma.

Journal: Investigative ophthalmology & visual science 20120822

Title: Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.

Journal: Molecular and cellular biochemistry 20111201

Title: Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.

Journal: Molecular vision 20110101

Title: Interaction of CJZ3, a lomerizine derivative, with ATPase activity of human P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.

Journal: Die Pharmazie 20100701

Title: Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice.

Journal: CNS neuroscience & therapeutics 20100401

Title: Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine.

Journal: Brain research bulletin 20100316

Title: A case of ocular hypertension complicated by SUNCT syndrome.

Journal: Annals of ophthalmology (Skokie, Ill.) 20100101

Title: Secondary retinal ganglion cell death and the neuroprotective effects of the calcium channel blocker lomerizine.

Journal: Investigative ophthalmology & visual science 20091101

Title: Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.

Journal: Journal of pharmacological sciences 20091001

Title: [Calcium antagonists in the prophylactic treatment of migraine].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20091001

Title: Secondary degeneration of the optic nerve following partial transection: the benefits of lomerizine.

Journal: Experimental neurology 20090301

Title: Cognitive impairment and cerebral hypoperfusion in a CADASIL patient improved during administration of lomerizine.

Journal: Clinical neuropharmacology 20090101

Title: [CADASIL].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20081101

Title: Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood.

Journal: Journal of pharmacological sciences 20080901

Title: Atypical depression as a premonitory symptom of migraine managed by an oral contraceptive.

Journal: Psychiatry and clinical neurosciences 20080601

Title: Migraine-associated vertigo: clinical characteristics of Japanese patients and effect of lomerizine, a calcium channel antagonist.

Journal: Acta oto-laryngologica. Supplementum 20071201

Title: CJZ3, a lomerizine derivative, modulates P-glycoprotein function in rat brain microvessel endothelial cells.

Journal: Acta pharmacologica Sinica 20060401

Title: A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat.

Journal: Current eye research 20060301

Title: [Reversal of multidrug resistance by lomerizine in K562/ADM cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20040501

Title: Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage.

Journal: Cardiovascular drug reviews 20040101

Title: [Effects of changes in conformation and configuration of N-containing compounds on NMR spactra].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20031201

Title: Effects of lomerizine, a calcium channel antagonist, on retinal and optic nerve head circulation in rabbits and humans.

Journal: Investigative ophthalmology & visual science 20031101

Title: Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine.

Journal: Biological & pharmaceutical bulletin 20010501

Title: Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010401

Title: Tran LT, et al. The voltage-gated calcium channel blocker Lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43. J Neurochem. 2014 Aug;130(3):455-66.

Title: Zhu HJ, et al. [Reversal of multidrug resistance by Lomerizine in K562/ADM cells Yao Xue Xue Bao. 2004 May;39(5):333-7.

Title: Nakamura-Yanagidaira T, et al. Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation. Mol Vis. 2011;17:2157-70.

Title: Shimazawa M, et al. Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats. Br J Pharmacol. 1995 Aug;115(8):1359-68.

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