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1017452-64-0,MFCD07376377
Catalog No.:AA0005AZ

1017452-64-0 | 2-(2,6-Difluorophenyl)thiazole-4-carboxylic acid

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Purity
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500mg
95%
in stock  
$383.00   $268.00
- +
1g
95%
in stock  
$561.00   $393.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0005AZ
Chemical Name:
2-(2,6-Difluorophenyl)thiazole-4-carboxylic acid
CAS Number:
1017452-64-0
Molecular Formula:
C10H5F2NO2S
Molecular Weight:
241.2140
MDL Number:
MFCD07376377
SMILES:
Fc1cccc(c1c1scc(n1)C(=O)O)F
Properties
Computed Properties
 
Complexity:
270  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2010/216839,2010,A1Locationinpatent:Page/Pagecolumn45

[2]Burger,MatthewT.;Nishiguchi,Gisele;Han,Wooseok;Lan,Jiong;Simmons,Robert;Atallah,Gordana;Ding,Yu;Tamez,Victoriano;Zhang,Yanchen;Mathur,Michelle;Muller,Kristine;Bellamacina,Cornelia;Lindvall,MikaK.;Zang,Richard;Huh,Kay;Feucht,Paul;Zavorotinskaya,Tatiana;Dai,Yumin;Basham,Steve;Chan,Julie;Ginn,Elaine;Aycinena,Alex;Holash,Jocelyn;Castillo,Joseph;Langowski,JohnL.;Wang,Yingyun;Chen,MinY.;Lambert,Amy;Fritsch,Christine;Kauffmann,Audry;Pfister,Estelle;Vanasse,K.Gary;Garcia,PabloD.[JournalofMedicinalChemistry,2015,vol.58,#21,p.8373-8386]

[3]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2009/109576,2009,A1Locationinpatent:Page/Pagecolumn106-107

[1]CurrentPatentAssignee:INCYTECORP-US2014/200227,2014,A1Locationinpatent:Paragraph0553;0554

[2]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2010/216839,2010,A1Locationinpatent:Page/Pagecolumn44

[3]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2012/4217,2012,A1Locationinpatent:Page/Pagecolumn60-61

[4]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2012/225061,2012,A1Locationinpatent:Page/Pagecolumn23

[5]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2013/175388,2013,A1Locationinpatent:Page/Pagecolumn73

[6]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2014/33631,2014,A1Locationinpatent:Page/Pagecolumn81

[7]Burger,MatthewT.;Nishiguchi,Gisele;Han,Wooseok;Lan,Jiong;Simmons,Robert;Atallah,Gordana;Ding,Yu;Tamez,Victoriano;Zhang,Yanchen;Mathur,Michelle;Muller,Kristine;Bellamacina,Cornelia;Lindvall,MikaK.;Zang,Richard;Huh,Kay;Feucht,Paul;Zavorotinskaya,Tatiana;Dai,Yumin;Basham,Steve;Chan,Julie;Ginn,Elaine;Aycinena,Alex;Holash,Jocelyn;Castillo,Joseph;Langowski,JohnL.;Wang,Yingyun;Chen,MinY.;Lambert,Amy;Fritsch,Christine;Kauffmann,Audry;Pfister,Estelle;Vanasse,K.Gary;Garcia,PabloD.[JournalofMedicinalChemistry,2015,vol.58,#21,p.8373-8386]

[8]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2009/109576,2009,A1Locationinpatent:Page/Pagecolumn104

[9]Wang,Xiaojing;Blackaby,Wesley;Allen,Vivienne;Chan,GraceKaYan;Chang,JaeH.;Chiang,Po-Chang;Diène,Coura;Drummond,Jason;Do,Steven;Fan,Eric;Harstad,EricB.;Hodges,Alastair;Hu,Huiyong;Jia,Wei;Kofie,William;Kolesnikov,Aleksandr;Lyssikatos,JosephP.;Ly,Justin;Matteucci,Mizio;Moffat,JohnG.;Munugalavadla,Veerendra;Murray,Jeremy;Nash,David;Noland,CameronL.;DelRosario,Geoff;Ross,Leanne;Rouse,Craig;Sharpe,Andrew;Slaga,Dionysos;Sun,Minghua;Tsui,Vickie;Wallweber,Heidi;Yu,Shang-Fan;Ebens,AllenJ.[JournalofMedicinalChemistry,2019]

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2012/4217,2012,A1

[2]Burger,MatthewT.;Nishiguchi,Gisele;Han,Wooseok;Lan,Jiong;Simmons,Robert;Atallah,Gordana;Ding,Yu;Tamez,Victoriano;Zhang,Yanchen;Mathur,Michelle;Muller,Kristine;Bellamacina,Cornelia;Lindvall,MikaK.;Zang,Richard;Huh,Kay;Feucht,Paul;Zavorotinskaya,Tatiana;Dai,Yumin;Basham,Steve;Chan,Julie;Ginn,Elaine;Aycinena,Alex;Holash,Jocelyn;Castillo,Joseph;Langowski,JohnL.;Wang,Yingyun;Chen,MinY.;Lambert,Amy;Fritsch,Christine;Kauffmann,Audry;Pfister,Estelle;Vanasse,K.Gary;Garcia,PabloD.[JournalofMedicinalChemistry,2015,vol.58,#21,p.8373-8386]

[3]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2009/109576,2009,A1

[4]Wang,Xiaojing;Blackaby,Wesley;Allen,Vivienne;Chan,GraceKaYan;Chang,JaeH.;Chiang,Po-Chang;Diène,Coura;Drummond,Jason;Do,Steven;Fan,Eric;Harstad,EricB.;Hodges,Alastair;Hu,Huiyong;Jia,Wei;Kofie,William;Kolesnikov,Aleksandr;Lyssikatos,JosephP.;Ly,Justin;Matteucci,Mizio;Moffat,JohnG.;Munugalavadla,Veerendra;Murray,Jeremy;Nash,David;Noland,CameronL.;DelRosario,Geoff;Ross,Leanne;Rouse,Craig;Sharpe,Andrew;Slaga,Dionysos;Sun,Minghua;Tsui,Vickie;Wallweber,Heidi;Yu,Shang-Fan;Ebens,AllenJ.[JournalofMedicinalChemistry,2019]

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2012/4217,2012,A1

[2]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2012/225061,2012,A1

[3]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2013/175388,2013,A1

[4]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2014/33631,2014,A1

[5]Burger,MatthewT.;Nishiguchi,Gisele;Han,Wooseok;Lan,Jiong;Simmons,Robert;Atallah,Gordana;Ding,Yu;Tamez,Victoriano;Zhang,Yanchen;Mathur,Michelle;Muller,Kristine;Bellamacina,Cornelia;Lindvall,MikaK.;Zang,Richard;Huh,Kay;Feucht,Paul;Zavorotinskaya,Tatiana;Dai,Yumin;Basham,Steve;Chan,Julie;Ginn,Elaine;Aycinena,Alex;Holash,Jocelyn;Castillo,Joseph;Langowski,JohnL.;Wang,Yingyun;Chen,MinY.;Lambert,Amy;Fritsch,Christine;Kauffmann,Audry;Pfister,Estelle;Vanasse,K.Gary;Garcia,PabloD.[JournalofMedicinalChemistry,2015,vol.58,#21,p.8373-8386]

[6]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2009/109576,2009,A1

[7]Wang,Xiaojing;Blackaby,Wesley;Allen,Vivienne;Chan,GraceKaYan;Chang,JaeH.;Chiang,Po-Chang;Diène,Coura;Drummond,Jason;Do,Steven;Fan,Eric;Harstad,EricB.;Hodges,Alastair;Hu,Huiyong;Jia,Wei;Kofie,William;Kolesnikov,Aleksandr;Lyssikatos,JosephP.;Ly,Justin;Matteucci,Mizio;Moffat,JohnG.;Munugalavadla,Veerendra;Murray,Jeremy;Nash,David;Noland,CameronL.;DelRosario,Geoff;Ross,Leanne;Rouse,Craig;Sharpe,Andrew;Slaga,Dionysos;Sun,Minghua;Tsui,Vickie;Wallweber,Heidi;Yu,Shang-Fan;Ebens,AllenJ.[JournalofMedicinalChemistry,2019]

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US2014/88117,2014,A1Locationinpatent:Page/Pagecolumn

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Tags:1017452-64-0 Molecular Formula|1017452-64-0 MDL|1017452-64-0 SMILES|1017452-64-0 2-(2,6-Difluorophenyl)thiazole-4-carboxylic acid