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101827-46-7,MFCD00917064
Catalog No.:AA0005KW

101827-46-7 | Butenafine HCl

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Purity
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1mg
98%
in stock  
$6.00   $4.00
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1g
98%
in stock  
$16.00   $11.00
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5g
98%
in stock  
$29.00   $21.00
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10g
98%
in stock  
$41.00   $29.00
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25g
98%
in stock  
$94.00   $66.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0005KW
Chemical Name:
Butenafine HCl
CAS Number:
101827-46-7
Molecular Formula:
C23H28ClN
Molecular Weight:
353.9281
MDL Number:
MFCD00917064
SMILES:
CN(Cc1cccc2c1cccc2)Cc1ccc(cc1)C(C)(C)C.Cl
Properties
Properties
 
Form:
Solid  
MP:
208-210°C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
374  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  

Downstream Synthesis Route
65542-26-9    86-52-2   
butenafinehydrochloride 

[1]CurrentPatentAssignee:KAKENPHARMACEUTICALCOLTD-US5021458,1991,A

[1]Chan,JessicaZ.;Yesilcimen,Ahmet;Cao,Min;Zhang,Yuyang;Zhang,Bochao;Wasa,Masayuki[JournaloftheAmericanChemicalSociety,2020,vol.142,#38,p.16493-16505]

[1]Chan,JessicaZ.;Yesilcimen,Ahmet;Cao,Min;Zhang,Yuyang;Zhang,Bochao;Wasa,Masayuki[JournaloftheAmericanChemicalSociety,2020,vol.142,#38,p.16493-16505]

[1]CurrentPatentAssignee:LUNANPHARMACEUTICALGROUPCOLTD-CN112209838,2021,ALocationinpatent:Paragraph0060-0077

Literature

Title: Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl)ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Trichophyton rubrum.

Journal: European journal of medicinal chemistry 20131001

Title: Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115

Title: A simple and rapid method to assess butenafine hydrochloride in skin samples and a comparative cutaneous retention study of two marketed formulations.

Journal: Biomedical chromatography : BMC 20111001

Title: Stability-indicating LC assay for butenafine hydrochloride in creams using an experimental design for robustness evaluation and photodegradation kinetics study.

Journal: Journal of chromatographic science 20110801

Title: RP-HPLC method for simultaneous determination of butenafine hydrochloride and betamethasone dipropionate in a cream formulation.

Journal: Journal of AOAC International 20110101

Title: [Activity of butenafine against ocular pathogenic filamentous fungi in vitro].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20100101

Title: Butenafine and superficial mycoses: current status.

Journal: Expert opinion on drug metabolism & toxicology 20080701

Title: An unprecedented rearrangement in collision-induced mass spectrometric fragmentation of protonated benzylamines.

Journal: Journal of mass spectrometry : JMS 20060901

Title: [The effect of propyl gallate on the activity of various antifungal drugs against filamentous fungi in vitro].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20060401

Title: In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine.

Journal: Biological & pharmaceutical bulletin 20050801

Title: Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial.

Journal: The Journal of dermatological treatment 20050101

Title: Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria.

Journal: International journal of dermatology 20030901

Title: Butenafine: an update of its use in superficial mycoses.

Journal: Skin therapy letter 20020901

Title: Experimental and conformational analyses of interactions between butenafine and lipids.

Journal: Antimicrobial agents and chemotherapy 20011201

Title: Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis).

Journal: Journal of the Indian Medical Association 20010501

Title: Butenafine hydrochloride (Mentax) cream for the treatment of hyperkeratotic type tinea pedis and its transfer into the horny layer, with or without concomitant application of 20% urea ointment (Keratinamin).

Journal: Mycoses 20010101

Title: Azole antifungal agents related to naftifine and butenafine.

Journal: Archiv der Pharmazie 20000601

Title: Butenafine hydrochloride: for the treatment of interdigital tinea pedis.

Journal: Expert opinion on pharmacotherapy 20000301

Title: Butenafine, a fungicidal benzylamine derivative, used once daily for the treatment of interdigital tinea pedis.

Journal: International journal of dermatology 19980601

Title: Butenafine.

Journal: Drugs 19980301

Title: Two mechanisms of butenafine action in Candida albicans.

Journal: Antimicrobial agents and chemotherapy 19930401

Title: [Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 19910201

Title: Singal A. Butenafine and superficial mycoses: current status. Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):999-1005.

Title: Kokjohn K, Bradley M, Griffiths B, Ghannoum M. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol. 2003 Sep;42 Suppl 1:11-7.

Title: Syed TA, Maibach HI. Butenafine hydrochloride: for the treatment of interdigital tinea pedis. Expert Opin Pharmacother. 2000 Mar;1(3):467-73.

Title: McNeely W, Spencer CM. Butenafine. Drugs. 1998 Mar;55(3):405-12; discussion 413.

Title: Butenafine

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