Home Fluorides 10212-20-1
10212-20-1,MFCD00057445
Catalog No.:AA0006LX

10212-20-1 | 2'-Deoxy-2'-fluorocytidine

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250mg
95%
in stock  
$16.00   $11.00
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1g
95%
in stock  
$37.00   $26.00
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5g
98%(HPLC)
in stock  
$127.00   $89.00
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25g
97%
in stock  
$477.00   $334.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0006LX
Chemical Name:
2'-Deoxy-2'-fluorocytidine
CAS Number:
10212-20-1
Molecular Formula:
C9H12FN3O4
Molecular Weight:
245.2077
MDL Number:
MFCD00057445
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)F)n1ccc(nc1=O)N
Properties
Computed Properties
 
Complexity:
386  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-1.1  

Literature

Title: In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections.

Journal: Antiviral research 20111101

Title: Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20091001

Title: Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

Journal: Bioorganic & medicinal chemistry letters 20070501

Title: Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.

Journal: Antiviral chemistry & chemotherapy 20060101

Title: Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Journal: Journal of medicinal chemistry 20050825

Title: Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

Journal: Bioorganic & medicinal chemistry 20050301

Title: Synthesis of some 2'-fluoro-2'-deoxy-3'-C-ethynyl and 3'-C-vinyl-beta-D-lyxofuranosyl nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

Journal: Antimicrobial agents and chemotherapy 20040201

Title: Measurement of the anti-cancer agent gemcitabine in human plasma by high-performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030225

Title: A new class of Spiegelmers containing 2'-fluoro-nucleotides.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Quantification of 2'-fluoro-2'-deoxyuridine and 2'-fluoro-2'-deoxycytidine in DNA and RNA isolated from rats and woodchucks using LC/MS/MS.

Journal: Chemical research in toxicology 20020701

Title: Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.

Journal: Journal of medicinal chemistry 19790101

Title: Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.

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