Title: Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170901
Title: Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication.
Journal: Archives of toxicology 20170101
Title: Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases.
Journal: Chemico-biological interactions 20161125
Title: Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease.
Journal: Chemico-biological interactions 20160405
Title: The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
Journal: Chemico-biological interactions 20130905
Title: Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.
Journal: Journal of applied toxicology : JAT 20130401
Title: A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
Journal: Chemico-biological interactions 20130325
Title: Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease.
Journal: The international journal of biochemistry & cell biology 20130201
Title: An efficient total synthesis of (-)-huperzine A.
Journal: Organic letters 20120907
Title: Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
Journal: Neurochemical research 20120901
Title: Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901
Title: Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.
Journal: Drug development and industrial pharmacy 20120601
Title: Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.
Journal: Toxicology mechanisms and methods 20120401
Title: Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.
Journal: Cold Spring Harbor perspectives in medicine 20120301
Title: Chiral separation of Huperzine A using CE - method validation and application in pharmaceutical formulations.
Journal: Electrophoresis 20120201
Title: Treatment with Huperzine A improves cognition in vascular dementia patients.
Journal: Cell biochemistry and biophysics 20120101
Title: Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis.
Journal: Acta pharmacologica Sinica 20120101
Title: Examining the interactome of huperzine A by magnetic biopanning.
Journal: PloS one 20120101
Title: [+]-Huperzine A protects against soman toxicity in guinea pigs.
Journal: Neurochemical research 20111201
Title: Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata.
Journal: Journal of industrial microbiology & biotechnology 20110901
Title: An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production.
Journal: Mini reviews in medicinal chemistry 20110901
Title: Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
Journal: Brain research 20110715
Title: The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.
Journal: Neuropharmacology 20110601
Title: Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110401
Title: Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method.
Journal: Nanomedicine : nanotechnology, biology, and medicine 20110201
Title: Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants.
Journal: Phytochemical analysis : PCA 20110101
Title: Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
Journal: Neuro endocrinology letters 20110101
Title: Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.
Journal: Pharmacology, biochemistry, and behavior 20101001
Title: Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment.
Journal: Journal of pharmaceutical and biomedical analysis 20100605
Title: Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.
Journal: Chemical & pharmaceutical bulletin 20100501
Title: Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.
Journal: Journal of neuroscience research 20100301
Title: Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.
Journal: Neuroscience letters 20100205
Title: Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.
Journal: Pharmacology, biochemistry, and behavior 20100101
Title: Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
Journal: The Journal of pharmacology and experimental therapeutics 20091201
Title: Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
Journal: Bioorganic & medicinal chemistry 20091001
Title: Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001
Title: Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.
Journal: Epilepsy & behavior : E&B 20090801
Title: Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
Journal: Nutritional neuroscience 20090801
Title: Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
Journal: Acta pharmacologica Sinica 20090701
Title: [Release mechanism of huperzine-A swelling sustained-release tablets].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701
Title: BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.
Journal: European journal of pharmacology 20090624
Title: Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.
Journal: Free radical biology & medicine 20090601
Title: Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins.
Journal: Journal of chromatography. A 20090320
Title: Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
Journal: Organic letters 20090319
Title: Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.
Journal: Brain, behavior, and immunity 20090101
Title: Huperzine A for vascular dementia.
Journal: The Cochrane database of systematic reviews 20090101
Title: Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids.
Journal: Journal of AOAC International 20090101
Title: Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
Journal: Chemico-biological interactions 20080925
Title: Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease.
Journal: Chemico-biological interactions 20080925
Title: [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
Journal: Chemico-biological interactions 20080925
Title: The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20080916
Title: Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.
Journal: Journal of neuroscience research 20080815
Title: Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.
Journal: Journal of neurochemistry 20080801
Title: Huperzine A for Alzheimer's disease.
Journal: The Cochrane database of systematic reviews 20080416
Title: Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
Journal: Biomedical chromatography : BMC 20080401
Title: Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method.
Journal: Journal of agricultural and food chemistry 20080213
Title: Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase.
Journal: Cellular and molecular neurobiology 20080201
Title: [Effects of huperzine A on cognitive function of rats recovering from general anesthesia].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080201
Title: Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.
Journal: Cellular and molecular neurobiology 20080101
Title: Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.
Journal: Neurotoxicity research 20080101
Title: Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Journal: Neuroscience 20071205
Title: East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Journal: Current Alzheimer research 20070901
Title: Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector.
Journal: Journal of pharmaceutical and biomedical analysis 20070509
Title: Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.
Journal: Neuroreport 20070507
Title: Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.
Journal: Schizophrenia research 20070501
Title: Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
Journal: Toxicology 20070420
Title: Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Journal: Toxicology 20070420
Title: The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.
Journal: Fitoterapia 20070401
Title: Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.
Journal: Basic & clinical pharmacology & toxicology 20070301
Title: Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.
Journal: FEBS letters 20070220
Title: Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography.
Journal: Journal of chromatography. A 20070126
Title: Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method.
Journal: Biomedical chromatography : BMC 20070101
Title: Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Journal: Current topics in medicinal chemistry 20070101
Title: Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal: Journal of medicinal chemistry 20061116
Title: [Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061101
Title: Editorial: natural products chemistry in China.
Journal: Natural product reports 20061001
Title: Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
Journal: Journal of neuroscience research 20060901
Title: Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.
Journal: Acta pharmacologica Sinica 20060901
Title: Harmless herbs? Think again: merits of a complete medication history.
Journal: Journal of the American Medical Directors Association 20060901
Title: Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20060829
Title: Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.
Journal: Biochemical pharmacology 20060728
Title: Acetylcholinesterase triggers the aggregation of PrP 106-126.
Journal: Biochemical and biophysical research communications 20060721
Title: Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20060701
Title: Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Journal: Journal of medicinal chemistry 20060601
Title: [Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060601
Title: Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.
Journal: Journal of neuroscience research 20060501
Title: [Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim].
Journal: Wei sheng yan jiu = Journal of hygiene research 20060501
Title: Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases.
Journal: Journal of pharmaceutical and biomedical analysis 20060411
Title: Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS.
Journal: Journal of pharmaceutical and biomedical analysis 20060303
Title: Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
Title: Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20060101
Title: Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
Journal: Acta pharmacologica Sinica 20060101
Title: In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid).
Journal: Chemical & pharmaceutical bulletin 20060101
Title: Herbal medicine in the treatment of Alzheimer's disease.
Journal: American journal of Alzheimer's disease and other dementias 20060101
Title: Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation.
Journal: Current medicinal chemistry 20060101
Title: Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
Journal: Chemico-biological interactions 20051215
Title: Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.
Journal: Journal of neurochemistry 20051201
Title: Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
Journal: Brain research 20051109
Title: A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales.
Journal: Journal of separation science 20051101
Title: Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
Journal: European journal of pharmacology 20050905
Title: Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks.
Journal: Journal of chromatography. A 20050819
Title: Huperzine A--human serum albumin association: chromatographic and thermodynamic approach.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050625
Title: Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.
Journal: Acta pharmacologica Sinica 20050601
Title: Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325
Title: Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.
Journal: Neuroscience letters 20050221
Title: Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase.
Journal: Pharmacology, biochemistry, and behavior 20050101
Title: Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.
Journal: Neuro-Signals 20050101
Title: The Lycopodium alkaloids.
Journal: Natural product reports 20041201
Title: (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
Journal: Journal of Alzheimer's disease : JAD 20041201
Title: Recent pharmacological studies on natural products in China.
Journal: European journal of pharmacology 20041001
Title: Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
Journal: Neuroscience letters 20040506
Title: Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.
Journal: Acta pharmacologica Sinica 20030901
Title: A convergent approach to huperzine A and analogues.
Journal: Organic & biomolecular chemistry 20030821
Title: Effects of huperzine A on liver cytochrome P-450 in rats.
Journal: Acta pharmacologica Sinica 20030801
Title: [Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030501
Title: Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons.
Journal: Neuroscience letters 20030410
Title: Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401
Title: Acute effects of huperzine A and tacrine on rat liver.
Journal: Acta pharmacologica Sinica 20030301
Title: Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030301
Title: Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.
Journal: European journal of pharmacology 20030214
Title: Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases.
Journal: Cellular and molecular neurobiology 20030201
Title: Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.
Journal: Phytotherapy research : PTR 20030101
Title: Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Journal: European journal of pharmacology 20021129
Title: Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.
Journal: International immunopharmacology 20021001
Title: X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
Journal: Biochemistry 20020903
Title: [Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901
Title: Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
Journal: Drug and chemical toxicology 20020801
Title: Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.
Journal: Neuroscience letters 20020510
Title: Review of the value of huperzine as pretreatment of organophosphate poisoning.
Journal: Neurotoxicology 20020501
Title: 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Journal: Biochemistry 20020305
Title: Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.
Journal: Neuroscience letters 20020215
Title: Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice.
Journal: Neuroscience letters 20020114
Title: Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation.
Journal: Journal of neuroscience research 20020101
Title: Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.
Journal: European journal of pharmacology 20011221
Title: The NMDA receptor ion channel: a site for binding of Huperzine A.
Journal: Journal of applied toxicology : JAT 20011201
Title: Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
Journal: Neuroscience letters 20011109
Title: Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Journal: Mini reviews in medicinal chemistry 20010701
Title: Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
Journal: Neuroscience letters 20010622
Title: Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability.
Journal: Drug and chemical toxicology 20010501
Title: Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
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Title: Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-D-aspartate receptors.
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Title: Effects of Huperzine used as pre-treatment against soman-induced seizures.
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Title: Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
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Title: Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
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Title: Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats.
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