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113617-63-3,MFCD00864858
Catalog No.:AA00093L

113617-63-3 | 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-, rel-

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100mg
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$29.00   $21.00
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250mg
99%
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$42.00   $29.00
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1g
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$101.00   $71.00
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5g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00093L
Chemical Name:
3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-, rel-
CAS Number:
113617-63-3
Molecular Formula:
C19H20F3N3O3
Molecular Weight:
395.3756
MDL Number:
MFCD00864858
SMILES:
C[C@@H]1N[C@H](C)CN(C1)c1c(F)c(F)c2c(c1F)n(cc(c2=O)C(=O)O)C1CC1
NSC Number:
758614
Properties
Computed Properties
 
Complexity:
691  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
0.9  

Downstream Synthesis Route

[1]Miyamoto,Teruyuki;Matsumoto,Jun-ichi;Chiba,Katsumi;Egawa,Hiroshi;Shibamori,Koh-ichiro;etal.[JournalofMedicinalChemistry,1990,vol.33,#6,p.1645-1656]

[1]Morimura;Ohno;Matsukura;Nobuhara[ChemicalandPharmaceuticalBulletin,1995,vol.43,#6,p.1052-1054]

113617-63-3   
1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline 

[1]Morimura;Ohno;Matsukura;Nobuhara[ChemicalandPharmaceuticalBulletin,1995,vol.43,#6,p.1052-1054]

113617-63-3   
7-(2-aminopropylamino)-1-cyclopropyl-5,6-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylicacid 
 
7-(2-aminopropylamino)-1-cyclopropyl-6-fluoro-1,4-dihydro-5-hydroxy-4-oxoquinoline-3-carboxylicacid 
 
5,6-difluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylicacid 

[1]Morimura,Tetsu;Nobuhara,Yoshifumi;Matsukura,Hayashi[ChemicalandPharmaceuticalBulletin,1997,vol.45,#2,p.373-377]

113617-63-3   
7-(2-aminopropylamino)-1-cyclopropyl-5,6-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylicacid 
 
5,6-difluoro-1,4-dihydro-7-(cis-3,5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylicacid 
 
8-Chloro-1-cyclopropyl-7-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-5,6-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylicacid 

[1]Morimura,Tetsu;Kohno,Kaoru;Nobuhara,Yoshifumi;Matsukura,Hayashi[ChemicalandPharmaceuticalBulletin,1997,vol.45,#11,p.1828-1832]

[2]Morimura,Tetsu;Kohno,Kaoru;Nobuhara,Yoshifumi;Matsukura,Hayashi[ChemicalandPharmaceuticalBulletin,1997,vol.45,#11,p.1828-1832]

Literature

Title: Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius.

Journal: Veterinary dermatology 20120801

Title: Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120215

Title: Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: current status of antimicrobial resistance and prevailing resistance mechanisms.

Journal: Microbiology and immunology 20120201

Title: Mutant prevention concentration and phenotypic and molecular basis of fluoroquinolone resistance in clinical isolates and in vitro-selected mutants of Escherichia coli from dogs.

Journal: Veterinary microbiology 20120127

Title: Multiclass analysis of 23 veterinary drugs in milk by ultraperformance liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120115

Title: Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs.

Journal: Acta veterinaria Scandinavica 20120101

Title: Complications from residual adnexal structures following enucleation in three dogs.

Journal: Journal of the American Veterinary Medical Association 20111215

Title: Comparative pharmacokinetics of orbifloxacin in healthy and Pasteurella multocida infected ducks.

Journal: British poultry science 20111001

Title: Rapid screening method for quinolone residues in livestock and fishery products using immobilised metal chelate affinity chromatographic clean-up and liquid chromatography-fluorescence detection.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110901

Title: Multidrug-resistant Acinetobacter baumannii in veterinary clinics, Germany.

Journal: Emerging infectious diseases 20110901

Title: Pharmacokinetic-pharmacodynamic integration of orbifloxacin in Japanese quail (Coturnix japonica) following oral and intravenous administration.

Journal: Journal of veterinary pharmacology and therapeutics 20110801

Title: Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents.

Journal: Bioorganic & medicinal chemistry letters 20110715

Title: Allometric scaling of orbifloxacin disposition in nine mammal species: a retrospective analysis.

Journal: The Journal of veterinary medical science 20110601

Title: 2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention.

Journal: Journal of veterinary internal medicine 20110101

Title: Short-term synaptic plasticity in the dentate gyrus of monkeys.

Journal: PloS one 20110101

Title: Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases.

Journal: Veterinary medicine international 20110101

Title: Determination of residual fluoroquinolones in honey by liquid chromatography using metal chelate affinity chromatography.

Journal: Journal of AOAC International 20110101

Title: Solvent-free microwave-assisted extraction of fluoroquinolones from soil and liquid chromatography-fluorescence determination.

Journal: Journal of chromatography. A 20101119

Title: Short communication: Fluoroquinolone susceptibility of Staphylococcus aureus strains isolated from caprine clinical mastitis in southeast Spain.

Journal: Journal of dairy science 20101101

Title: Single-step extraction followed by LC for determination of (fluoro)quinolone drug residues in muscle, eggs, and milk.

Journal: Journal of separation science 20100401

Title: Rapid determination of fluoroquinolone residues in honey by a microbiological screening method and liquid chromatography.

Journal: Journal of AOAC International 20100101

Title: Quantitation of fluoroquinolones in honey using tandem mass spectrometry (LC-MS/MS): nested validation with two mass spectrometers.

Journal: Journal of AOAC International 20100101

Title: Pharmacokinetics and milk distribution characteristics of orbifloxacin following intravenous and intramuscular injection in lactating ewes.

Journal: Journal of veterinary pharmacology and therapeutics 20090801

Title: Human-to-dog transmission of methicillin-resistant Staphylococcus aureus.

Journal: Emerging infectious diseases 20090801

Title: Free-radical-induced oxidative and reductive degradation of fluoroquinolone pharmaceuticals: kinetic studies and degradation mechanism.

Journal: The journal of physical chemistry. A 20090709

Title: Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of orbifloxacin in Korean Hanwoo cattle.

Journal: Journal of veterinary pharmacology and therapeutics 20090601

Title: Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090301

Title: Approaches for application of sub and supercritical fluid extraction for quantification of orbifloxacin from plasma and milk: application to disposition kinetics.

Journal: Analytica chimica acta 20090105

Title: [Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20090101

Title: Implementation of terbium-sensitized luminescence in sequential-injection analysis for automatic analysis of orbifloxacin.

Journal: Analytical and bioanalytical chemistry 20081201

Title: Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections.

Journal: Veterinary microbiology 20080918

Title: Quality by design, part I: application of NIR spectroscopy to monitor tablet manufacturing process.

Journal: Journal of pharmaceutical sciences 20080901

Title: Quality by design, part II: application of NIR spectroscopy to monitor the coating process for a pharmaceutical sustained release product.

Journal: Journal of pharmaceutical sciences 20080901

Title: Quality by design, part III: study of curing process of sustained release coated products using NIR spectroscopy.

Journal: Journal of pharmaceutical sciences 20080901

Title: Drug resistance mechanism of the fish-pathogenic bacterium Lactococcus garvieae.

Journal: Journal of fish diseases 20080601

Title: Pharmacokinetics and milk penetration of orbifloxacin after intravenous and intramuscular injections to dromedary lactating camels (Camelus dromedaries).

Journal: Journal of veterinary pharmacology and therapeutics 20080601

Title: Multiresidue determination of quinolones in animal and fishery products by HPLC.

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080601

Title: Pharmacokinetic-pharmacodynamic integration of orbifloxacin in rabbits after intravenous, subcutaneous and intramuscular administration.

Journal: Journal of veterinary pharmacology and therapeutics 20080201

Title: Pharmacokinetics and milk penetration of orbifloxacin after intravenous, subcutaneous, and intramuscular administration to lactating goats.

Journal: Journal of dairy science 20070901

Title: [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20070701

Title: Lack of inhibitory effects of several fluoroquinolones on cytochrome P-450 3A activities at clinical dosage in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20070201

Title: Antimicrobial testing of selected fluoroquinolones against Pseudomonas aeruginosa isolated from canine otitis.

Journal: Journal of the American Animal Hospital Association 20070101

Title: Efficacy of orbifloxacin tablets for the treatment of superficial and deep pyoderma due to Staphylococcus intermedius infection in dogs.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20061001

Title: The pharmacokinetics of orbifloxacin in the horse following oral and intravenous administration.

Journal: Journal of veterinary pharmacology and therapeutics 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Comparison of pharmacodynamic and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats.

Journal: Journal of veterinary internal medicine 20060101

Title: Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20051201

Title: Hepatocellular toxicosis associated with the alternate administration of carprofen and meloxicam in a siberian husky.

Journal: The Journal of veterinary medical science 20051001

Title: Multiresidue determination of fluoroquinolones in shrimp by liquid chromatography-fluorescence-mass spectrometry.

Journal: Journal of AOAC International 20050101

Title: Modulation of cellular immune response by orbifloxacin in noninfected and E. coli-infected mice.

Journal: Immunopharmacology and immunotoxicology 20050101

Title: In vitro antimicrobial activity of orbifloxacin against Staphylococcus intermedius isolates from canine skin and ear infections.

Journal: Research in veterinary science 20040801

Title: Determination of quinolones and fluoroquinolones in fish tissue and seafood by high-performance liquid chromatography with electrospray ionisation tandem mass spectrometric detection.

Journal: Journal of chromatography. A 20021220

Title: Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021115

Title: Comparative serum pharmacokinetics of the fluoroquinolones enrofloxacin, difloxacin, marbofloxacin, and orbifloxacin in dogs after single oral administration.

Journal: Journal of veterinary pharmacology and therapeutics 20020201

Title: Determination of plasma and skin concentrations of orbifloxacin in dogs with clinically normal skin and dogs with pyoderma.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Pharmacokinetics of orbifloxacin and its concentration in body fluids and in endometrial tissues of mares.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20010701

Title: Harada K, et al. Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs. Acta Vet Scand. 2012 Mar 20;54:16.

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Tags:113617-63-3 Molecular Formula|113617-63-3 MDL|113617-63-3 SMILES|113617-63-3 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-5,6,8-trifluoro-1,4-dihydro-4-oxo-, rel-