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1191951-57-1,MFCD18384970
Catalog No.:AA000I82

1191951-57-1 | PHT-427

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
10mg
98%
in stock  
$36.00   $25.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000I82
Chemical Name:
PHT-427
CAS Number:
1191951-57-1
Molecular Formula:
C20H31N3O2S2
Molecular Weight:
409.6090
MDL Number:
MFCD18384970
SMILES:
CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc1nncs1
Properties
Computed Properties
 
Complexity:
474  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
14  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
7.4  

Literature

Title: Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

Journal: Molecular cancer therapeutics 20100301

Title: Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

Journal: Bioorganic & medicinal chemistry 20091001

Title: In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

Journal: Cancer research 20090615

Title: Structure, regulation and function of PKB/AKT--a major therapeutic target.

Journal: Biochimica et biophysica acta 20040311

Title: Role of Akt signaling in vascular homeostasis and angiogenesis.

Journal: Circulation research 20020628

Title: Meuillet EJ, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17.

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Tags:1191951-57-1 Molecular Formula|1191951-57-1 MDL|1191951-57-1 SMILES|1191951-57-1 PHT-427
Catalog No.: AA000I82
1191951-57-1,MFCD18384970
1191951-57-1 | PHT-427
Pack Size： 1mg
Purity： 98%
in stock
$11.00 $8.00
Pack Size： 10mg
Purity： 98%
in stock
$36.00 $25.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000I82
Chemical Name: PHT-427
CAS Number: 1191951-57-1
Molecular Formula: C20H31N3O2S2
Molecular Weight: 409.6090
MDL Number: MFCD18384970
SMILES: CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc1nncs1
Properties
Complexity: 474  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 14  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 7.4  
Literature fold

Title: Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

Journal: Molecular cancer therapeutics20100301

Title: Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

Journal: Bioorganic & medicinal chemistry20091001

Title: In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

Journal: Cancer research20090615

Title: Structure, regulation and function of PKB/AKT--a major therapeutic target.

Journal: Biochimica et biophysica acta20040311

Title: Role of Akt signaling in vascular homeostasis and angiogenesis.

Journal: Circulation research20020628

Title: Meuillet EJ, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17.

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