Home Other Building Blocks 1207456-01-6
1207456-01-6,MFCD22666357
Catalog No.:AA008TBR

1207456-01-6 | Bmn-673

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
2mg
98%
in stock  
$25.00   $18.00
- +
100mg
98%
in stock  
$353.00   $247.00
- +
250mg
98%
in stock  
$560.00   $392.00
- +
1g
98%
in stock  
$1,432.00   $1,003.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TBR
Chemical Name:
Bmn-673
CAS Number:
1207456-01-6
Molecular Formula:
C19H14F2N6O
Molecular Weight:
380.3509
MDL Number:
MFCD22666357
SMILES:
Fc1ccc(cc1)[C@H]1Nc2cc(F)cc3c2c([C@@H]1c1ncnn1C)n[nH]c3=O
Properties
Computed Properties
 
Complexity:
654  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
2.3  

Literature

Title: Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.

Journal: Nature genetics 20180801

Title: PARP inhibitors: A new era of targeted therapy.

Journal: Maturitas 20150501

Title: Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone.

Journal: Acta crystallographica. Section F, Structural biology communications 20140901

Title: Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.

Journal: Cancer research 20121101

Title: Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.

Journal: Nature structural & molecular biology 20101001

Title: Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido,3,2-dephthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent. J Med Chem. 2016 Jan 14;59(1):335-57.

Title: Shen Y, et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.Clin Cancer Res. 2013 Sep 15;19(18):5003-15.

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