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127294-70-6,MFCD00864925
Catalog No.:AA000WTN

127294-70-6 | 1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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500mg
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98%(HPLC)
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10g
98%(HPLC)
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000WTN
Chemical Name:
1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS Number:
127294-70-6
Molecular Formula:
C20H24FN3O4
Molecular Weight:
389.4207
MDL Number:
MFCD00864925
SMILES:
CNC1CCCN(C1)c1c(F)cc2c(c1OC)n(cc(c2=O)C(=O)O)C1CC1
Properties
Computed Properties
 
Complexity:
668  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
0.6  

Downstream Synthesis Route
3-methylaminopiperidinedihydrochloride 
 
(PhO)3B 
  112811-72-0   
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-(3-methylaminopiperidin-1-yl)-3-quinolinecarboxylicacid 

[1]Patent:US5869661,1999,A

3-methylaminopiperidinedihydrochloride 
  112811-72-0   
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-(3-methylaminopiperidin-1-yl)-3-quinolinecarboxylicacid 

[1]Patent:EP2130827,2009,A1.Locationinpatent:Page/Pagecolumn12

[2]Patent:US5051509,1991,A

[1]Locationinpatent:experimentalpartFeng,Lian-Shun;Liu,Ming-Liang;Wang,Bo;Chai,Yun;Hao,Xue-Qin;Meng,Shuai;Guo,Hui-Yuan[EuropeanJournalofMedicinalChemistry,2010,vol.45,#8,p.3407-3412]

[1]Locationinpatent:experimentalpartFeng,Lian-Shun;Liu,Ming-Liang;Wang,Bo;Chai,Yun;Hao,Xue-Qin;Meng,Shuai;Guo,Hui-Yuan[EuropeanJournalofMedicinalChemistry,2010,vol.45,#8,p.3407-3412]

[1]Li,Qing;Xing,Junhao;Cheng,Haibo;Wang,Hui;Wang,Jing;Wang,Shuai;Zhou,Jinpei;Zhang,Huibin[ChemicalBiologyandDrugDesign,2015,vol.85,#1,p.79-90]

Literature

Title: Alterations of protein complexes and pathways in genetic information flow and response to stimulus contribute to Escherichia coli resistance to balofloxacin.

Journal: Molecular bioSystems 20120901

Title: Downregulation of Na(+)-NQR complex is essential for Vibrio alginolyticus in resistance to balofloxacin.

Journal: Journal of proteomics 20120517

Title: In the quest of drugs for bad bugs: are newer fluoroquinolones any better?

Journal: Journal of laboratory physicians 20110101

Title: Synthesis and in vitro antimycobacterial activity of balofloxacin ethylene isatin derivatives.

Journal: European journal of medicinal chemistry 20100801

Title: Aquatic photochemistry of fluoroquinolone antibiotics: kinetics, pathways, and multivariate effects of main water constituents.

Journal: Environmental science & technology 20100401

Title: Gatifloxacin, moxifloxacin, and balofloxacin resistance due to mutations in the gyrA and parC genes of Staphylococcus epidermidis strains isolated from patients with endophthalmitis, corneal ulcers and conjunctivitis.

Journal: Ophthalmic research 20090101

Title: Ethyl 1-cyclo-propyl-6,7-difluoro-8-meth-oxy-4-oxo-1,4-dihydro-quinoline-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20081101

Title: [Synthesis and antibacterial activity of 7-(3-amino-4-alkoxyimino-1 -piperidyl) -quinolones].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080801

Title: [Determination of balofloxacin in human plasma by HPLC with solid-phase extraction].

Journal: Se pu = Chinese journal of chromatography 20071101

Title: High performance liquid chromatography-electrospray ionization mass spectrometric determination of balofloxacin in human plasma and its pharmacokinetics.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Title: [Studies on the reaction of balofloxacin with bovine serum albumin].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20060801

Title: Electrophysiological safety of novel fluoroquinolone antibiotic agents gemifloxacin and balofloxacin.

Journal: Drug and chemical toxicology 20060101

Title: [Interaction between balofloxacin and DNA and the influence of Mg2+ on the interaction].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050701

Title: Balofloxacin Choongwae.

Journal: Current opinion in investigational drugs (London, England : 2000) 20030201

Title: [In vitro antimycobacterial activities of a new quinolone, balofloxacin].

Journal: Kekkaku : [Tuberculosis] 20010101

Title: History of quinolones and their side effects.

Journal: Chemotherapy 20010101

Title: [In vitro anti-MAC activities of new quinolones in focus (2)].

Journal: Kekkaku : [Tuberculosis] 19960901

Title: [Determination of antimycobacterial activities of fluoroquinolones against clinical isolates of Mycobacterium tuberculosis: comparative determination with egg-based Ogawa and agar-based Middlebrook 7H10 media].

Journal: Kekkaku : [Tuberculosis] 19960801

Title: Alksne L. Balofloxacin Choongwae. Curr Opin Investig Drugs. 2003 Feb;4(2):224-9.

Title: Jiang H, et, al. In vitro and in vivo effectiveness evaluation of balofloxacin in experimental Staphylococcus aureus keratitis. J Ocul Pharmacol Ther. 2014 Aug;30(6):482-8.

Title: Gohara Y, et, al. In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumonia. Antimicrob Agents Chemother. 1993 Sep;37(9):1826-30.

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Tags:127294-70-6 Molecular Formula|127294-70-6 MDL|127294-70-6 SMILES|127294-70-6 1-cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid