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131-55-5,MFCD00002278
Catalog No.:AA000V7E

131-55-5 | 2,2',4,4'-Tetrahydroxybenzophenone

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5g
98%
in stock  
$6.00   $4.00
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10g
98%
in stock  
$7.00   $5.00
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25g
98%
in stock  
$12.00   $8.00
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100g
98%
in stock  
$31.00   $22.00
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500g
98%
in stock  
$150.00   $105.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000V7E
Chemical Name:
2,2',4,4'-Tetrahydroxybenzophenone
CAS Number:
131-55-5
Molecular Formula:
C13H10O5
Molecular Weight:
246.2155
MDL Number:
MFCD00002278
SMILES:
Oc1ccc(c(c1)O)C(=O)c1ccc(cc1O)O
NSC Number:
38556
Properties
Properties
 
BP:
531.2 °C at 760 mmHg  
Form:
Solid  
MP:
198-200 °C  
Refractive Index:
1.4825 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
278  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.4  

Literature

Title: The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats.

Journal: Toxicology 20180601

Title: Identification and Molecular Interaction Studies of Thyroid Hormone Receptor Disruptors among Household Dust Contaminants.

Journal: Chemical research in toxicology 20160815

Title: Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughput in vitro Data, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160501

Title: Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.

Journal: Toxicology and applied pharmacology 20141001

Title: Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Journal: Scientific reports 20140101

Title: Pseudopolymorphism in hydroxybenzophenones: the dihydrate of 2,2',4,4'-tetrahydroxybenzophenone.

Journal: Acta crystallographica. Section C, Crystal structure communications 20120401

Title: Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120201

Title: Ovariectomized mouse uterotrophic assay of 36 chemicals.

Journal: The Journal of toxicological sciences 20120101

Title: Effect of 2,2',4,4'-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells.

Journal: Toxicology 20111009

Title: Identification of classifiers for increase or decrease of thyroid peroxidase activity in the FTC-238/hTPO recombinant cell line.

Journal: Environmental science & technology 20110915

Title: Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis.

Journal: Environmental science & technology 20110901

Title: Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.

Journal: Toxicology letters 20100215

Title: True photoallergy to sunscreens is rare despite popular belief.

Journal: Dermatitis : contact, atopic, occupational, drug 20100101

Title: Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) - an analysis with nonlinear isobolograms.

Journal: Toxicology and applied pharmacology 20090101

Title: Simultaneous trace determination of nine organic UV-absorbing compounds (UV filters) in environmental samples.

Journal: Journal of chromatography. A 20080815

Title: Pharmacokinetics and metabolism of benzophenone 2 in the rat.

Journal: Toxicology 20080312

Title: Cloud point extraction combined with micellar electrokinetic capillary chromatography determination of benzophenones in cosmetic matrix.

Journal: Electrophoresis 20080201

Title: Effects of the UV filter benzophenone-2 on reproduction in fish.

Journal: Toxicology and applied pharmacology 20071215

Title: In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism.

Journal: The Journal of urology 20071001

Title: The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase.

Journal: Endocrinology 20070601

Title: Estrogenic activity of UV filter mixtures.

Journal: Toxicology and applied pharmacology 20061115

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats.

Journal: Archives of toxicology 20061001

Title: In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes.

Journal: Immunopharmacology and immunotoxicology 20060101

Title: Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (E2) in ovariectomized (ovx) rats.

Journal: Toxicology 20050915

Title: [Estrogenic activity of ultraviolet absorbers and the related compounds].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050801

Title: Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens.

Journal: Toxicology and applied pharmacology 20050215

Title: Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment.

Journal: Toxicology 20041201

Title: Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone.

Journal: Toxicology 20041201

Title: Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats.

Journal: Toxicology 20041201

Title: Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals.

Journal: Toxicology letters 20030430

Title: Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals.

Journal: Toxicology 20030201

Title: Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.

Journal: Environmental health perspectives 20010201

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