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149-87-1,MFCD00064322
Catalog No.:AA001L99

149-87-1 | Dl-pyroglutamic acid

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25g
99%
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$6.00   $4.00
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100g
99%
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$11.00   $8.00
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500g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001L99
Chemical Name:
Dl-pyroglutamic acid
CAS Number:
149-87-1
Molecular Formula:
C5H7NO3
Molecular Weight:
129.1140
MDL Number:
MFCD00064322
SMILES:
O=C1CC[C@H](N1)C(=O)O
Properties
Properties
 
BP:
453.1°C at 760 mmHg  
Form:
Solid  
MP:
183-185 °C  
Refractive Index:
1.4220 (estimate)  
Solubility:
52g/l  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
154  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.8  

Literature

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Title: Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin.

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Title: Chiral sensing using an achiral europium(III) complex by induced circularly polarized luminescence.

Journal: Inorganic chemistry 20120402

Title: Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease.

Journal: The Journal of biological chemistry 20120309

Title: Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120301

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Title: Active diuretic peptidomimetic insect kinin analogs that contain β-turn mimetic motif 4-aminopyroglutamate and lack native peptide bonds.

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Title: Zinc l-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis.

Journal: International journal of cosmetic science 20120201

Title: Role of brainstem thyrotropin-releasing hormone-triggered sympathetic overactivation in cardiovascular mortality in type 2 diabetic Goto-Kakizaki rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120201

Title: Elevated cytokinin content in ipt transgenic creeping bentgrass promotes drought tolerance through regulating metabolite accumulation.

Journal: Journal of experimental botany 20120201

Title: The retina is a target for GnRH-3 system in the European sea bass, Dicentrarchus labrax.

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Title: Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase.

Journal: Journal of experimental botany 20120201

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Journal: Arzneimittel-Forschung 20120201

Title: Developing a comparative docking protocol for the prediction of peptide selectivity profiles: investigation of potassium channel toxins.

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Title: Two flushing-like reaction cases from calcium pidolate who tolerated calcium carbonate.

Journal: Allergologia et immunopathologia 20120101

Title: Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody.

Journal: Journal of Alzheimer's disease : JAD 20120101

Title: Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect.

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Title: A distinct metabolic signature predicts development of fasting plasma glucose.

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Journal: International journal of molecular sciences 20120101

Title: Identification and functional characterization of two orphan G-protein-coupled receptors for adipokinetic hormones from silkworm Bombyx mori.

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Journal: The British journal of nutrition 20111001

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Journal: Amino acids 20110701

Title: Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.

Journal: Allergy 20110701

Title: Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells.

Journal: Investigative ophthalmology & visual science 20110701

Title: Expression of vesicular glutamate transporter-2.1 in medaka terminal nerve gonadotrophin-releasing hormone neurones.

Journal: Journal of neuroendocrinology 20110701

Title: Application of gene targeting to designed mutation breeding of high-tryptophan rice.

Journal: Plant physiology 20110701

Title: Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus.

Journal: The Journal of biological chemistry 20110617

Title: Synthesis of quaternary stereogenic centres via stereoselective intermolecular Friedel-Crafts reactions.

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Journal: Endocrinology 20110401

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Journal: Biochemical and biophysical research communications 20110401

Title: Preparation and chiro-optical characterization of polyaniline doped with (+) or (-)-2-pyrrolidone-5-carboxylic acid (PCA).

Journal: Chirality 20110401

Title: Temperature affects brain and pituitary gene expression related to reproduction and growth in the male blue gouramis, Trichogaster trichopterus.

Journal: Journal of experimental zoology. Part A, Ecological genetics and physiology 20110401

Title: A sister group contrast using untargeted global metabolomic analysis delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus.

Journal: The Plant cell 20110401

Title: Novel methodologies for the synthesis of functionalized pyroglutamates.

Journal: Chemical communications (Cambridge, England) 20110321

Title: The first decapeptide adipokinetic hormone (AKH) in Heteroptera: a novel AKH from a South African saucer bug, Laccocoris spurcus (Naucoridae, Laccocorinae).

Journal: Peptides 20110301

Title: Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy.

Journal: Neurochemical research 20110301

Title: Chiral recognition at one-dimensional metal-organic coordination networks initiates the ordering of prochiral catalytic reagent methylacetoacetate on Au{111}.

Journal: Langmuir : the ACS journal of surfaces and colloids 20110301

Title: Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury.

Journal: Neurochemistry international 20110301

Title: Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.

Journal: The Journal of biological chemistry 20110211

Title: Mind the gap! An unusual metabolic acidosis.

Journal: Lancet (London, England) 20110205

Title: Calcium and zinc complexes of pyrroglutamate analogs detected by electrospray ionization mass spectrometry.

Journal: Amino acids 20110201

Title: Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.

Journal: Chemico-biological interactions 20110201

Title: Removal of N-terminal blocking groups from proteins.

Journal: Current protocols in protein science 20110201

Title: [Role of the brain in the regulation of metabolism and energy expenditure: the central role of insulin, and insulin resistance of the brain].

Journal: Orvosi hetilap 20110116

Title: Seasonal changes of brain GnRH-I, -II, and -III during the final reproductive period in adult male and female sea lamprey.

Journal: General and comparative endocrinology 20110115

Title: A method for N-terminal de novo sequencing of Nα-blocked proteins by mass spectrometry.

Journal: The Analyst 20110107

Title: The systemic inhibition of nitric oxide production rapidly regulates TRH mRNA concentration in the paraventricular nucleus of the hypothalamus and serum TSH concentration. Studies in control and cold-stressed rats.

Journal: Brain research 20110107

Title: Compensatory expression and substrate inducibility of gamma-glutamyl transferase GGT2 isoform in Arabidopsis thaliana.

Journal: Journal of experimental botany 20110101

Title: Luteinizing Hormone-Releasing Hormone (LHRH)-I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivo.

Journal: Molecular cancer therapeutics 20110101

Title: The putative AKH receptor of the tobacco hornworm, Manduca sexta, and its expression.

Journal: Journal of insect science (Online) 20110101

Title: Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound.

Journal: BMC chemical biology 20110101

Title: NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model.

Journal: Acta neurochirurgica. Supplement 20110101

Title: Isolation and identification of the umami enhancing compounds in Japanese soy sauce.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Mn bioavailability by polarized Caco-2 cells: comparison between Mn gluconate and Mn oxyprolinate.

Journal: Nutrition journal 20110101

Title: Renal mitochondrial cytopathies.

Journal: International journal of nephrology 20110101

Title: Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.

Journal: Molecular systems biology 20110101

Title: Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.

Journal: International journal of molecular sciences 20110101

Title: [Dynamics of antipirin test at patients with alcoholic liver disease on the background of metadoksin drug receiving].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Title: Prediction of protein modification sites of pyrrolidone carboxylic acid using mRMR feature selection and analysis.

Journal: PloS one 20110101

Title: Pyroglutamic aciduria: a cause of high anion-gap metabolic acidosis associated with common drugs.

Journal: Irish medical journal 20110101

Title: Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.

Journal: The Journal of biological chemistry 20101231

Title: Cytotoxicity of dentine bonding agents on human pulp cells is related to intracellular glutathione levels.

Journal: International endodontic journal 20101201

Title: Influence of synthetic lamprey GnRH-III on gonadotropin release and steroid hormone levels in gilts.

Journal: Theriogenology 20101201

Title: Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.

Journal: Peptides 20101201

Title: Pyroglutamate-Aβ: role in the natural history of Alzheimer's disease.

Journal: The international journal of biochemistry & cell biology 20101201

Title: Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus.

Journal: The Journal of allergy and clinical immunology 20101201

Title: Signal transduction, plasma membrane calcium movements, and pigment translocation in freshwater shrimp chromatophores.

Journal: Journal of experimental zoology. Part A, Ecological genetics and physiology 20101101

Title: A unified strategy targeting the thiodiketopiperazine mycotoxins exserohilone, gliotoxin, the epicoccins, the epicorazines, rostratin A and aranotin.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20101011

Title: Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Journal: Journal of medicinal chemistry 20100923

Title: Zinc ions bind to and inhibit activated protein C.

Journal: Thrombosis and haemostasis 20100901

Title: Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.

Journal: Bioorganic & medicinal chemistry letters 20100901

Title: Oral magnesium supplementation improves vascular function in elderly diabetic patients.

Journal: Magnesium research 20100901

Title: 5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose.

Journal: The Journal of the American Osteopathic Association 20100901

Title: Profound metabolic acidosis from pyroglutamic acidemia: an underappreciated cause of high anion gap metabolic acidosis.

Journal: CJEM 20100901

Title: Potent hyperglycemic and hyperinsulinemic effects of thyrotropin-releasing hormone microinjected into the rostroventrolateral medulla and abnormal responses in type 2 diabetic rats.

Journal: Neuroscience 20100825

Title: Complementary treatment with oral pidotimod plus vitamin C after laser vaporization for female genital warts: a prospective study.

Journal: Journal of medicine and life 20100815

Title: Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease.

Journal: Acta neuropathologica 20100801

Title: Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice.

Journal: Peptides 20100801

Title: Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801

Title: Adult Drosophila melanogaster as a model for the study of glucose homeostasis.

Journal: Aging 20100801

Title: Negligible effect of oral garlic oil on the oral absorption of pyridoxine in metadoxine in rats.

Journal: Archives of pharmacal research 20100701

Title: Role of late maternal thyroid hormones in cerebral cortex development: an experimental model for human prematurity.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20100601

Title: Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.

Journal: Biochimica et biophysica acta 20100601

Title: OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases.

Journal: FEMS yeast research 20100601

Title: Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats.

Journal: Metabolic brain disease 20100601

Title: Signal pathway of GnRH-III inhibiting FSH-induced steroidogenesis in granulosa cells.

Journal: Frontiers in bioscience (Elite edition) 20100601

Title: A role of Histidine151 in the lamprey gonadotropin-releasing hormone receptor-1 (lGnRHR-1): Functional insight of diverse amino acid residues in the position of Tyr of the DRY motif in GnRHR from an ancestral type II receptor.

Journal: General and comparative endocrinology 20100501

Title: Locust adipokinetic hormones mobilize diacylglycerols selectively.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20100501

Title: Cytosolic action of phytochelatin synthase.

Journal: Plant physiology 20100501

Title: Cytotoxicity of chlorhexidine on human osteoblastic cells is related to intracellular glutathione levels.

Journal: International endodontic journal 20100501

Title: A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus.

Journal: Molecular and cellular endocrinology 20100412

Title: Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry.

Journal: Amino acids 20100401

Title: A novel function of red pigment-concentrating hormone in crustaceans: Porcellio scaber (Isopoda) as a model species.

Journal: General and comparative endocrinology 20100401

Title: Glutathione modulators reverse the pro-tumour effect of growth factors enhancing WiDr cell response to chemotherapeutic agents.

Journal: Anticancer research 20100401

Title: Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.

Journal: The Journal of biological chemistry 20100326

Title: Synthesis of amino acid conjugates to 2-imino-3-methylene-5-carboxypyrrolidine and 2-imino-3-methylene-6-carboxypiperidine.

Journal: Bioorganic & medicinal chemistry letters 20100315

Title: Nephrolithiasis related to inborn metabolic diseases.

Journal: Pediatric nephrology (Berlin, Germany) 20100301

Title: Biological activity of the predicted red pigment-concentrating hormone of Daphnia pulex in a crustacean and an insect.

Journal: General and comparative endocrinology 20100301

Title: A novel member of the adipokinetic peptide family in a 'living fossil', the ice crawler Galloisiana yuasai, is the first identified neuropeptide from the order Grylloblattodea.

Journal: Peptides 20100301

Title: A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?

Journal: Journal of biosciences 20100301

Title: Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule.

Journal: Analytical biochemistry 20100201

Title: Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation.

Journal: Peptides 20100101

Title: Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20100101

Title: An integrated functional genomic study of acute phenobarbital exposure in the rat.

Journal: BMC genomics 20100101

Title: Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.

Journal: PloS one 20100101

Title: 5-Oxoproline (pyroglutamic) acidosis associated with chronic acetaminophen use.

Journal: Proceedings (Baylor University. Medical Center) 20100101

Title: Benzothiadiazole and l-2-oxothiazolidine-4-carboxylic acid reduce the severity of Sharka symptoms in pea leaves: effect on antioxidative metabolism at the subcellular level.

Journal: Plant biology (Stuttgart, Germany) 20100101

Title: [Severe metabolic acidosis as a result of 5-oxoproline in acetaminophen use].

Journal: Nederlands tijdschrift voor geneeskunde 20100101

Title: Taurine in health and diseases: consistent evidence from experimental and epidemiological studies.

Journal: Journal of biomedical science 20100101

Title: Procysteine increases alcohol-depleted glutathione stores in rat plantaris following a period of abstinence.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20100101

Title: Metabolomic profiling of cellular responses to carvedilol enantiomers in vascular smooth muscle cells.

Journal: PloS one 20100101

Title: Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group.

Journal: Bioorganic & medicinal chemistry 20091201

Title: Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.

Journal: Journal of medicinal chemistry 20091126

Title: From N-triisopropylsilylpyrrole to an optically active C-4 substituted pyroglutamic acid: total synthesis of penmacric acid.

Journal: Organic & biomolecular chemistry 20091107

Title: Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level.

Journal: International immunopharmacology 20091101

Title: Incorporation of N-amidino-pyroglutamic acid into peptides using intramolecular cyclization of alpha-guanidinoglutaric acid.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20091101

Title: Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods.

Journal: The British journal of dermatology 20091101

Title: 4,4'-Bipyridine-pyroglutamic acid (1/2).

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide.

Journal: Biochemical pharmacology 20091015

Title: Glutathione modulation reverses the growth-promoting effect of growth factors, improving the 5-fluorouracil antitumour response in WiDr colon cancer cells.

Journal: Anticancer research 20091001

Title: The protective effects of N-Acetl-cysteine, oxo-thiazolidine-carboxylate, acetaminophen and their combinations against sulfur mustard cytotoxicity on human skin fibroblast cell line (HF2FF).

Journal: Iranian biomedical journal 20091001

Title: Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid.

Journal: Toxicology 20090919

Title: Immunodominant epitope and properties of pyroglutamate-modified Abeta-specific antibodies produced in rabbits.

Journal: Journal of neuroimmunology 20090818

Title: High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815

Title: Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.

Journal: Archives of biochemistry and biophysics 20090815

Title: Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats.

Journal: Alcoholism, clinical and experimental research 20090801

Title: Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.

Journal: International journal of molecular medicine 20090801

Title: Concise asymmetric synthesis of configurationally stable 4-trifluoromethyl thalidomide.

Journal: Future medicinal chemistry 20090801

Title: Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.

Journal: Biochemistry 20090728

Title: L-2-Oxothiazolidine-4-carboxylate reverses glutathione oxidation and delays fatigue of skeletal muscle in vitro.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20090701

Title: Metabonomic study of ochratoxin a toxicity in rats after repeated administration: phenotypic anchoring enhances the ability for biomarker discovery.

Journal: Chemical research in toxicology 20090701

Title: Pyroglutamic acid promotes survival of retinal ganglion cells after optic nerve injury.

Journal: Current eye research 20090701

Title: Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence.

Journal: Endocrinology 20090501

Title: Desflurane but not sevoflurane can increase lung resistance via tachykinin pathways.

Journal: British journal of anaesthesia 20090501

Title: The orientation of BN-related peptides adsorbed on SERS-active silver nanoparticles: comparison with a silver electrode surface.

Journal: The journal of physical chemistry. B 20090409

Title: Peptides of the adipokinetic hormone/red pigment-concentrating hormone family: a new take on biodiversity.

Journal: Annals of the New York Academy of Sciences 20090401

Title: Gastric electrical stimulation for obesity: the need for a new device using wider pulses.

Journal: Obesity (Silver Spring, Md.) 20090301

Title: Promising therapies in sickle cell disease.

Journal: Cardiovascular & hematological disorders drug targets 20090301

Title: [Capsule metadoxine in the treatment of alcoholic liver disease: a randomized, double-blind, placebo-controlled, multicenter study].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090301

Title: Conversion of 4-oxoproline esters to 4-substituted pyrrole-2-carboxylic acid esters.

Journal: Chemical & pharmaceutical bulletin 20090201

Title: NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus.

Journal: Neuroscience letters 20090116

Title: Anticoagulant and antithrombotic activity of a new peptide pENW (pGlu-Asn-Trp).

Journal: The Journal of pharmacy and pharmacology 20090101

Title: Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes.

Journal: PloS one 20090101

Title: A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.

Journal: BMC evolutionary biology 20090101

Title: New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study of the effectiveness and safety of magnesium and vitamin B6.

Journal: Trials 20090101

Title: Pidotimod: a reappraisal.

Journal: International journal of immunopathology and pharmacology 20090101

Title: NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries.

Journal: Vascular pharmacology 20090101

Title: Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish.

Journal: Neural development 20090101

Title: [Non-alcoholic fatty liver disease: age peculiarities, breakthrough in pathogenetic therapy].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

Title: Pathophisiology of sickle cell disease and new drugs for the treatment.

Journal: Mediterranean journal of hematology and infectious diseases 20090101

Title: Synthesis of highly substituted pyroglutamates via a domino Michael addition-Claisen rearrangement-lactamisation approach.

Journal: Organic & biomolecular chemistry 20081221

Title: Acute alcohol intoxication.

Journal: European journal of internal medicine 20081201

Title: Biological activity and identification of neuropeptides in the neurosecretory complexes of the cabbage pest insect, Mamestra brassicae (Noctuidae; Lepidoptera).

Journal: Acta biologica Hungarica 20081201

Title: Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice.

Journal: Die Pharmazie 20081201

Title: Characterization of low-molecular-weight antiyeast metabolites produced by a food-protective Lactobacillus-Propionibacterium coculture.

Journal: Journal of food protection 20081201

Title: Synthesis of the phosphinic analogue of thyrotropin releasing hormone.

Journal: The Journal of organic chemistry 20081107

Title: Structural properties of bombesin-like peptides revealed by surface-enhanced Raman scattering on roughened silver electrodes.

Journal: Biopolymers 20081101

Title: Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release.

Journal: Peptides 20081101

Title: Effect of hypomagnesemia on allogeneic activation in mice.

Journal: Transplant immunology 20081101

Title: Stimulatory effects of bioamines norepinephrine and dopamine on locomotion of Pyrrhocoris apterus (L.): is the adipokinetic hormone involved?

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20081101

Title: A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis.

Journal: Plant physiology 20081101

Title: Expression of lipid storage droplet protein-1 may define the role of AKH as a lipid mobilizing hormone in Manduca sexta.

Journal: Insect biochemistry and molecular biology 20081101

Title: Participation of the cholinergic system in ameliorating effect of vasopressin fragment by group I metabotropic glutamate-receptor blockade.

Journal: Journal of pharmacological sciences 20081101

Title: Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus.

Journal: Journal of clinical biochemistry and nutrition 20081101

Title: Natural variation in plasticity of glucose homeostasis and food intake.

Journal: The Journal of experimental biology 20081001

Title: Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

Journal: Nature medicine 20081001

Title: Normal saline induces oxidative stress in peritoneal mesothelial cells.

Journal: Journal of pediatric surgery 20081001

Title: Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression.

Journal: Archives of pharmacal research 20080901

Title: Guilty as charged: unmeasured urinary anions in a case of pyroglutamic acidosis.

Journal: The Netherlands journal of medicine 20080901

Title: 5-Oxoproline as a cause of high anion gap metabolic acidosis: an uncommon cause with common risk factors.

Journal: The Netherlands journal of medicine 20080901

Title: Clinical applications of urinary organic acids. Part I: Detoxification markers.

Journal: Alternative medicine review : a journal of clinical therapeutic 20080901

Title: Impact of cyclosporine A on magnesium homeostasis: clinical observation in lung transplant recipients and experimental study in mice.

Journal: Transplantation 20080815

Title: Origins of gonadotropin-releasing hormone (GnRH) in vertebrates: identification of a novel GnRH in a basal vertebrate, the sea lamprey.

Journal: Endocrinology 20080801

Title: Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

Journal: Journal of neurochemistry 20080801

Title: Prothyrotropin-releasing hormone targets its processing products to different vesicles of the secretory pathway.

Journal: The Journal of biological chemistry 20080718

Title: Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.

Journal: Biochemistry 20080715

Title: Heterogeneity of monoclonal antibodies.

Journal: Journal of pharmaceutical sciences 20080701

Title: Increased metal tolerance in Salix by nicotinamide and nicotinic acid.

Journal: Plant physiology and biochemistry : PPB 20080701

Title: Analysis of glutamine, glutamate, pyroglutamate, and GABA in cerebrospinal fluid using ion pairing HPLC with positive electrospray LC/MS/MS.

Journal: Journal of neuroscience methods 20080630

Title: Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20080604

Title: Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry.

Journal: Toxicon : official journal of the International Society on Toxinology 20080601

Title: Neurokinin-3 peptide instead of neurokinin-1 synergistically exacerbates kainic acid-inducing degeneration of neurons in the substantia nigra of mice.

Journal: Journal of neurochemistry 20080401

Title: Identification of putative crustacean neuropeptides using in silico analyses of publicly accessible expressed sequence tags.

Journal: General and comparative endocrinology 20080401

Title: Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 A resolution.

Journal: Acta crystallographica. Section D, Biological crystallography 20080401

Title: Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling.

Journal: Cell metabolism 20080401

Title: Rapid action of estrogens on intracellular calcium oscillations in primate luteinizing hormone-releasing hormone-1 neurons.

Journal: Endocrinology 20080301

Title: Developmental regulation and functions of the expression of the neuropeptide corazonin in Drosophila melanogaster.

Journal: Cell and tissue research 20080301

Title: A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome.

Journal: Critical care medicine 20080301

Title: Differential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposure.

Journal: Hormones and behavior 20080201

Title: Comparison of insect kinin analogs with cis-peptide bond, type VI-turn motifs identifies optimal stereochemistry for interaction with a recombinant arthropod kinin receptor from the southern cattle tick Boophilus microplus.

Journal: Peptides 20080201

Title: Localization and thiol dependancy of endogenous nitro compounds-mediating urethral photo-relaxation.

Journal: Pflugers Archiv : European journal of physiology 20080101

Title: Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia.

Journal: British journal of haematology 20080101

Title: Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.

Journal: Acta biochimica Polonica 20080101

Title: Differentiation of Sclerotinia minor depends on thiol redox state and oxidative stress.

Journal: Canadian journal of microbiology 20080101

Title: [Effects of an antiischemic drug combination and nimodipine on cerebral blood supply in a hemorrhagic stroke model in rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20080101

Title: Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum.

Journal: Neuropeptides 20080101

Title: [Chemical constituents of Changium smyrnioides].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101

Title: Henoch-Schönlein purpura associated with pidotimod therapy.

Journal: Clinical and experimental rheumatology 20080101

Title: Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.

Journal: Muscle & nerve 20071201

Title: Analysis of time-related metabolic fluctuations induced by ethionine in the rat.

Journal: Journal of proteome research 20071201

Title: Identification of small molecules from human embryonic stem cells using metabolomics.

Journal: Stem cells and development 20071201

Title: [Pyroglutamic acidemia associated with acetaminophen].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20071201

Title: Diastereoselective synthesis of glutamate-appended oxolane rings: synthesis of (s)-(+)-lycoperdic acid.

Journal: The Journal of organic chemistry 20071123

Title: Cytotoxicity of formaldehyde on human osteoblastic cells is related to intracellular glutathione levels.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials 20071101

Title: Mass spectrometric identification of pyroglutamic acid in peptides following selective hydrolysis.

Journal: Analytical biochemistry 20071101

Title: Cold exposure increases the biosynthesis and proteolytic processing of prothyrotropin-releasing hormone in the hypothalamic paraventricular nucleus via beta-adrenoreceptors.

Journal: Endocrinology 20071001

Title: The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.

Journal: Fundamental & clinical pharmacology 20071001

Title: Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

Journal: Biochemistry 20070925

Title: Adipokinetic hormone-induced enhancement of antioxidant capacity of Pyrrhocoris apterus hemolymph in response to oxidative stress.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070901

Title: Profound metabolic acidosis and oxoprolinuria in an adult.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20070901

Title: Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity.

Journal: Chemico-biological interactions 20070830

Title: Sequencing of T-superfamily conotoxins from Conus virgo: pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20070801

Title: Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation.

Journal: Alcohol (Fayetteville, N.Y.) 20070801

Title: High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition.

Journal: Annals of clinical biochemistry 20070701

Title: Water scorpions (Heteroptera, Nepidae) and giant water bugs (Heteroptera, Belostomatidae): sources of new members of the adipokinetic hormone/red pigment-concentrating hormone family.

Journal: Peptides 20070701

Title: Crystal structures of two Bordetella pertussis periplasmic receptors contribute to defining a novel pyroglutamic acid binding DctP subfamily.

Journal: Journal of molecular biology 20070629

Title: Therapy and clinical trials.

Journal: Current opinion in lipidology 20070601

Title: Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors.

Journal: Chemical biology & drug design 20070601

Title: Magnesium as a preventive treatment for paediatric episodic tension-type headache: results at 1-year follow-up.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20070601

Title: Inhibitory effect of cyclooxygenase inhibitors on the step-through passive avoidance performance in mice treated with NC-1900, an arginine-vasopressin fragment analog.

Journal: Methods and findings in experimental and clinical pharmacology 20070601

Title: Expeditious access to unprotected racemic pyroglutamic acids.

Journal: The Journal of organic chemistry 20070511

Title: Oxidative folding and N-terminal cyclization of onconase.

Journal: Biochemistry 20070508

Title: Is the titer of adipokinetic peptides in Leptinotarsa decemlineata fed on genetically modified potatoes increased by oxidative stress?

Journal: Peptides 20070501

Title: A novel two-domain architecture within the amino acid kinase enzyme family revealed by the crystal structure of Escherichia coli glutamate 5-kinase.

Journal: Journal of molecular biology 20070413

Title: Quantification of urinary zwitterionic organic acids using weak-anion exchange chromatography with tandem MS detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

Title: Effects of a bacterial lipid byproduct on human pulp fibroblasts in vitro.

Journal: Journal of endodontics 20070401

Title: Adipokines in children with sleep disordered breathing.

Journal: Sleep 20070401

Title: Effect of NC-1900, an active fragment analog of arginine vasopressin, and inhibitors of arachidonic acid metabolism on performance of a passive avoidance task in mice.

Journal: European journal of pharmacology 20070329

Title: Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: an in vivo microdialysis study.

Journal: Neuroscience letters 20070319

Title: Structure design of multifunctional furoate and pyroglutamate esters of dextran by polymer-analogous reactions.

Journal: Macromolecular bioscience 20070308

Title: A novel adipokinetic peptide in a water boatman (Heteroptera, Corixidae) and its bioanalogue in a saucer bug (Heteroptera, Naucoridae).

Journal: Peptides 20070301

Title: 5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain.

Journal: Metabolic brain disease 20070301

Title: Effect of immunisation against gonadotrophin releasing hormone isoforms (mammalian GnRH-I, chicken GnRH-II and lamprey GnRH-III) on murine spermatogenesis.

Journal: Vaccine 20070301

Title: Oxidative stress contributes to accelerated development of the senescent phenotype in human peritoneal mesothelial cells exposed to high glucose.

Journal: Free radical biology & medicine 20070301

Title: Calcium movements during pigment aggregation in freshwater shrimp chromatophores.

Journal: Pigment cell research 20070201

Title: Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.

Journal: Biological chemistry 20070201

Title: Pharmacokinetics of metadoxine for injection after repeated doses in healthy volunteers.

Journal: Chinese medical journal 20070120

Title: An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro.

Journal: Brain research 20070112

Title: Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism.

Journal: American journal of physiology. Endocrinology and metabolism 20070101

Title: Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1.

Journal: Bioorganic & medicinal chemistry 20070101

Title: Comparison of insect kinin analogs with cis-peptide bond motif 4-aminopyroglutamate identifies optimal stereochemistry for diuretic activity.

Journal: Biopolymers 20070101

Title: Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L. plants.

Journal: Archives of virology 20070101

Title: Structure-activity relationships for in vitro diuretic activity of CAP2b in the housefly.

Journal: Peptides 20070101

Title: Urticaria due to calcium pidolate.

Journal: Allergologia et immunopathologia 20070101

Title: Combinatorial solution-phase synthesis of (2S,4S)-4-acylamino-5-oxopyrrolidine-2-carboxamides.

Journal: Journal of combinatorial chemistry 20070101

Title: Inborn errors in the metabolism of glutathione.

Journal: Orphanet journal of rare diseases 20070101

Title: Acetaminophen-induced hepatotoxicity in a glutathione synthetase-deficient patient.

Journal: The Turkish journal of pediatrics 20070101

Title: A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi.

Journal: Genome biology 20070101

Title: Hair and amino acids: the interactions and the effects.

Journal: Journal of cosmetic science 20070101

Title: Circadian rhythms of TRH-like peptide levels in rat brain.

Journal: Brain research 20061213

Title: Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion.

Journal: Endocrinology 20061201

Title: Efficient asymmetric synthesis of novel 4-substituted and configurationally stable analogues of thalidomide.

Journal: Organic letters 20061123

Title: Is lGnRH-III the most potent GnRH analog containing only natural amino acids that specifically inhibits the growth of human breast cancer cells?

Journal: Journal of peptide science : an official publication of the European Peptide Society 20061101

Title: Unfolding of the immunoglobulin light and heavy chains is required for the enzymatic removal of N-terminal pyroglutamyl residues.

Journal: Biochimica et biophysica acta 20061101

Title: Psychoneuroendocrinology of anorexia nervosa.

Journal: Psychoneuroendocrinology 20061101

Title: On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).

Journal: Biochemistry 20061017

Title: Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development.

Journal: Journal of pharmaceutical and biomedical analysis 20061011

Title: Improvement of cationic albumin conjugated pegylated nanoparticles holding NC-1900, a vasopressin fragment analog, in memory deficits induced by scopolamine in mice.

Journal: Behavioural brain research 20061002

Title: Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.

Journal: Biochimica et biophysica acta 20061001

Title: Effects of the tomato pathogen Fusarium oxysporum f. sp. radicis-lycopersici and of the biocontrol bacterium Pseudomonas fluorescens WCS365 on the composition of organic acids and sugars in tomato root exudate.

Journal: Molecular plant-microbe interactions : MPMI 20061001

Title: Endocrine control of TAG lipase in the fat body of the migratory locust, Locusta migratoria.

Journal: Insect biochemistry and molecular biology 20061001

Title: Occurrence of the free and Peptide forms of pyroglutamic acid in plasma from the portal blood of rats that had ingested a wheat gluten hydrolysate containing pyroglutamyl peptides.

Journal: Journal of agricultural and food chemistry 20060920

Title: Prostanoids contribute to cutaneous active vasodilation in humans.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060901

Title: An unusual cause of severe metabolic acidosis.

Journal: The Medical journal of Australia 20060821

Title: Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier.

Journal: FEBS letters 20060807

Title: Cytomodulation of interleukin-2 effect by L-2-oxothiazolidine-4-carboxylate on human malignant melanoma.

Journal: Cancer immunology, immunotherapy : CII 20060801

Title: Protective role of L-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060801

Title: Persistent 5-oxoprolinuria with normal glutathione synthase and 5-oxoprolinase activities.

Journal: Journal of inherited metabolic disease 20060801

Title: Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family.

Journal: The Journal of biological chemistry 20060707

Title: Identification of dopamine, gonadotrophin-releasing hormone-I, and vasoactive intestinal peptide neurones activated by electrical stimulation to the medial preoptic area of the turkey hypothalamus: a potential reproductive neuroendocrine circuit.

Journal: Journal of neuroendocrinology 20060701

Title: The role of tachykinins in circular muscle contractility of the murine ileum: a functional investigation.

Journal: Autonomic neuroscience : basic & clinical 20060630

Title: An antioxidant modulates expression of receptor activator of NF-kappaB in asthma.

Journal: Experimental & molecular medicine 20060630

Title: Capillary electrophoresis for caffeine and pyroglutamate determination in coffees study of the in vivo effect on learning and locomotor activity in mice.

Journal: Journal of pharmaceutical and biomedical analysis 20060616

Title: Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis.

Journal: Journal of proteome research 20060601

Title: Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid.

Journal: Chemical & pharmaceutical bulletin 20060601

Title: Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503

Title: Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin.

Journal: Endocrinology 20060501

Title: Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion.

Journal: Diabetologia 20060501

Title: Blood glucose lowering by means of lifestyle intervention has different effects on adipokines as compared with insulin treatment in subjects with type 2 diabetes.

Journal: Diabetologia 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen.

Journal: Clinical journal of the American Society of Nephrology : CJASN 20060501

Title: Investigation of a route to ibotenic acid analogues via a reduced pyroglutamate template.

Journal: Organic & biomolecular chemistry 20060421

Title: Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion.

Journal: Journal of neurophysiology 20060401

Title: Pathophysiologically based drug treatment of sickle cell disease.

Journal: Trends in pharmacological sciences 20060401

Title: Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts.

Journal: Acta pharmacologica Sinica 20060401

Title: Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodies.

Journal: Analytical chemistry 20060401

Title: Red pigment concentrating hormone strongly enhances the strength of the feedback to the pyloric rhythm oscillator but has little effect on pyloric rhythm period.

Journal: Journal of neurophysiology 20060301

Title: The detection of red pigment-concentrating hormone (RPCH) in crustacean eyestalk tissues using matrix-assisted laser desorption/ionization-Fourier transform mass spectrometry: [M + Na]+ ion formation in dried droplet tissue preparations.

Journal: Journal of mass spectrometry : JMS 20060301

Title: CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.

Journal: Clinica chimica acta; international journal of clinical chemistry 20060201

Title: Impaired activity of the gamma-glutamyl cycle in nephropathic cystinosis fibroblasts.

Journal: Pediatric research 20060201

Title: Antioxidants as novel agents for asthma.

Journal: Mini reviews in medicinal chemistry 20060201

Title: Roles of N-terminal pyroglutamate in maintaining structural integrity and pKa values of catalytic histidine residues in bullfrog ribonuclease 3.

Journal: Journal of molecular biology 20060120

Title: Disruption of disulfide bond formation alters the trafficking of prothyrotropin releasing hormone (proTRH)-derived peptides.

Journal: Regulatory peptides 20060115

Title: Anatomy of the Hesse photoreceptor cell axonal system in the central nervous system of amphioxus.

Journal: The Journal of comparative neurology 20060101

Title: New AZT conjugates as potent anti-HIV agents.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: [Correlations of pharmacokinetics and pharmacodynamics of a combined preparation containing pyrrolidone and pyroglutamic acid].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20060101

Title: Unmeasured anions in metabolic acidosis: unravelling the mystery.

Journal: Critical care (London, England) 20060101

Title: Day-night differences in membrane-bound pyroglutamyl-2-naphthylamide-hydrolyzing activity in rat hypothalamus, pituitary, and retina.

Journal: Chronobiology international 20060101

Title: Effect of pyrrolidone-pyroglutamic acid composition on blood flow in rat middle cerebral artery.

Journal: Bulletin of experimental biology and medicine 20060101

Title: Effects of glutathione supplementation during peritoneal dialysis.

Journal: Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 20060101

Title: Flight fuel and neuropeptidergic control of fuel mobilisation in the twig wilter, Holopterna alata (Hemiptera, Coreidae).

Journal: Journal of insect physiology 20060101

Title: [AMPK, an active player in the control of metabolism].

Journal: Journal de la Societe de biologie 20060101

Title: A follow up study on the efficacy of metadoxine in the treatment of alcohol dependence.

Journal: Substance abuse treatment, prevention, and policy 20060101

Title: [Clinical trials of new therapeutic pharmacology for sickle cell disease].

Journal: Sante (Montrouge, France) 20060101

Title: Altered glucose and insulin responses to brain medullary thyrotropin-releasing hormone (TRH)-induced autonomic activation in type 2 diabetic Goto-Kakizaki rats.

Journal: Endocrinology 20051201

Title: Molecular mechanisms during sperm capacitation.

Journal: Human fertility (Cambridge, England) 20051201

Title: Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach.

Journal: Magnesium research 20051201

Title: [Adipocytokins, obesity and development of type 2 diabetes].

Journal: Medecine sciences : M/S 20051201

Title: An efficient synthesis of the constrained peptidomimetic 2-oxo-3-(N-9-fluorenyloxycarbonylamino)-1-azabicyclo[4.3.0]nonane-9-carboxylic acid from pyroglutamic acid.

Journal: The Journal of organic chemistry 20051125

Title: [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].

Journal: Orvosi hetilap 20051120

Title: Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity.

Journal: Journal of the American Chemical Society 20051102

Title: Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats.

Journal: Regulatory peptides 20051101

Title: A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.

Journal: Molecular pharmacology 20051101

Title: Virucidal hand treatments for prevention of rhinovirus infection.

Journal: The Journal of antimicrobial chemotherapy 20051101

Title: Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.

Journal: European journal of pharmacology 20051017

Title: Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons.

Journal: Endocrinology 20051001

Title: [Studies on chemical constituents in leaf of Isatis indigotica].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001

Title: Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.

Journal: Regulatory peptides 20050915

Title: Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats.

Journal: Peptides 20050901

Title: Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats.

Journal: Peptides 20050901

Title: NC-1900, an arginine-vasopressin analogue, ameliorates social behavior deficits and hyperlocomotion in MK-801-treated rats: therapeutic implications for schizophrenia.

Journal: Brain research 20050816

Title: Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.

Journal: Organic & biomolecular chemistry 20050807

Title: Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.

Journal: Brain research 20050802

Title: Factor XIa dimer in the activation of factor IX.

Journal: Biochemistry 20050802

Title: Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs.

Journal: Peptides 20050801

Title: Neuronal-glial plasticity in gonadotropin-releasing hormone release in adult female rats: role of the polysialylated form of the neural cell adhesion molecule.

Journal: The Journal of endocrinology 20050801

Title: The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.

Journal: Analytical biochemistry 20050701

Title: Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20050701

Title: Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20050701

Title: Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050701

Title: Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases.

Journal: Organic letters 20050623

Title: Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.

Journal: Brain research 20050614

Title: Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.

Journal: Brain research. Molecular brain research 20050613

Title: Urinary tract infection in children.

Journal: Clinical evidence 20050601

Title: Synthesis of 3'-deoxy-3'-difluoromethyl azanucleosides from trans-4-hydroxy-l-proline.

Journal: The Journal of organic chemistry 20050513

Title: The newly discovered insect order Mantophasmatodea contains a novel member of the adipokinetic hormone family of peptides.

Journal: Biochemical and biophysical research communications 20050506

Title: Activation of triacylglycerol lipase in the fat body of a beetle by adipokinetic hormone.

Journal: Insect biochemistry and molecular biology 20050501

Title: Glutamate antagonists attenuate the action of NC-1900, a vasopressin fragment analog, on passive avoidance task performance in mice.

Journal: Peptides 20050501

Title: Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.

Journal: Journal of natural products 20050501

Title: Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation.

Journal: Cellular and molecular life sciences : CMLS 20050501

Title: Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase II activity in rat limbic regions.

Journal: Regulatory peptides 20050415

Title: Alteration of airway neuropeptide expression and development of airway hyperresponsiveness following respiratory syncytial virus infection.

Journal: American journal of physiology. Lung cellular and molecular physiology 20050401

Title: Quantification of cell-cycle distribution and mitotic index in Hydra by flow cytometry.

Journal: Cell proliferation 20050401

Title: Application of stability-indicating HPTLC method for quantitative determination of metadoxine in pharmaceutical dosage form.

Journal: Farmaco (Societa chimica italiana : 1989) 20050401

Title: Glutamatergic innervation of corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat.

Journal: Brain research 20050328

Title: Air-stable Ir-(P-Phos) complex for highly enantioselective hydrogenation of quinolines and their immobilization in poly(ethylene glycol) dimethyl ether (DMPEG).

Journal: Chemical communications (Cambridge, England) 20050321

Title: Straightforward ring expansion of pyroglutamates to perhydro-1,3-diazepine-2,4-diones.

Journal: Organic letters 20050317

Title: Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.

Journal: The Journal of biological chemistry 20050304

Title: Preparation and reactivity of aminoacyl pyroglutamates. Facile synthesis of 10-membered-ring cyclic dipeptides derived from 1,4-diaminobutyric and glutamic acids.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20050301

Title: Importance of the central region of lamprey gonadotropin-releasing hormone III in the inhibition of breast cancer cell growth.

Journal: Peptides 20050301

Title: Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions.

Journal: Neurochemistry international 20050301

Title: A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20050301

Title: Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.

Journal: Journal of medicinal chemistry 20050224

Title: Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats.

Journal: Regulatory peptides 20050215

Title: AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050201

Title: Evaluation of early gastric mucosal permeability induced by central thyrotropin-releasing hormone administration.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050201

Title: A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity.

Journal: Journal of neurochemistry 20050201

Title: Magnesium as a treatment for paediatric tension-type headache: a clinical replication series.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20050201

Title: First messenger regulation of mammalian sperm function via adenylyl cyclase/cAMP.

Journal: The Journal of reproduction and development 20050201

Title: Severe hyperhomocysteinaemia and 5-oxoprolinuria secondary to antiproliferative and antimicrobial drug treatment.

Journal: Journal of inherited metabolic disease 20050101

Title: Trial of erythropoietin treatment in a boy with glutathione synthetase deficiency.

Journal: Journal of inherited metabolic disease 20050101

Title: [Role of metadoxyl in the treatment of the hepatotoxic effects of cytostatics].

Journal: Voprosy onkologii 20050101

Title: An active insect kinin analog with 4-aminopyroglutamate, a novel cis-peptide bond, type VI beta-turn motif.

Journal: Biopolymers 20041205

Title: Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats.

Journal: Psychopharmacology 20041201

Title: Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201

Title: L-2-oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20041201

Title: Endopeptidase activity of larval Lacanobia oleracea corpus allatum: metabolism of Manduca sexta allatostatin and allatotropin.

Journal: Archives of insect biochemistry and physiology 20041201

Title: [Gluthathion synthetase deficit in a newborn infant].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20041101

Title: Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.

Journal: Oral diseases 20041101

Title: Diastereoselective syntheses of deoxydysibetaine, dysibetaine, and its 4-epimer.

Journal: The Journal of organic chemistry 20041029

Title: Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20041019

Title: Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.

Journal: Behavioural brain research 20041005

Title: Sequence and expression of the CAPA/CAP2b gene in the tobacco hawkmoth, Manduca sexta.

Journal: The Journal of experimental biology 20041001

Title: Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells.

Journal: Nature 20040916

Title: Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.

Journal: Cancer science 20040901

Title: Pyroglutamyl-asparagine amide normalizes long-term potentiation in rat hippocampal slices.

Journal: Bulletin of experimental biology and medicine 20040801

Title: Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines.

Journal: The Journal of organic chemistry 20040723

Title: [Antioxidants in liver protection].

Journal: Orvosi hetilap 20040704

Title: Facilitative effect of a novel AVP fragment analog, NC-1900, on memory retention and recall in mice.

Journal: Peptides 20040701

Title: 15Alpha-hydroxyprogesterone in male sea lampreys, Petromyzon marinus L.

Journal: Steroids 20040701

Title: [Study on the mechanism of male reproductive toxicity of metadoxine in mice and rats].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20040701

Title: Circadian rhythm of pigment migration induced by chromatrophorotropins in melanophores of the crab Chasmagnathus granulata.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040701

Title: Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.

Journal: Neuroscience letters 20040617

Title: Allosteric modification of factor XIa functional activity upon binding to polyanions.

Journal: Biochemistry 20040615

Title: Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder.

Journal: The American journal of psychiatry 20040601

Title: Effect of pretraining administration of NC-1900, a vasopressin fragment analog, on memory performance in non- or CO2-amnesic mice.

Journal: Pharmacology, biochemistry, and behavior 20040601

Title: GABAergic basal forebrain neurons that express receptor for neurokinin B and send axons to the cerebral cortex.

Journal: The Journal of comparative neurology 20040517

Title: Spawning and gamete follicle rupture in the cnidarian Renilla koellikeri: effects of putative neurohormones.

Journal: General and comparative endocrinology 20040515

Title: Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster.

Journal: Genetics 20040501

Title: Origin of diastereoselection in the hydrosilylation of chiral N-acyliminium intermediates derived from pyroglutamic acid.

Journal: Angewandte Chemie (International ed. in English) 20040426

Title: Application of intramolecular enyne metathesis to the synthesis of aza[4.2.1]bicyclics: enantiospecific total synthesis of (+)-anatoxin-a.

Journal: Organic letters 20040415

Title: 15alpha-hydroxytestosterone induction by GnRH I and GnRH III in Atlantic and Great Lakes sea lamprey (Petromyzon marinus L.).

Journal: General and comparative endocrinology 20040401

Title: The first total synthesis of a pyranonaphthoquinone antitumor, BE-54238B.

Journal: The Journal of antibiotics 20040401

Title: Central administration of cocaine- and amphetamine-regulated transcript increases phosphorylation of cAMP response element binding protein in corticotropin-releasing hormone-producing neurons but not in prothyrotropin-releasing hormone-producing neurons in the hypothalamic paraventricular nucleus.

Journal: Brain research 20040305

Title: Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid.

Journal: Intensive care medicine 20040301

Title: Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery.

Journal: Biological & pharmaceutical bulletin 20040301

Title: Human sperm responses to calcitonin, angiotensin II and fertilization-promoting peptide in prepared semen samples from normal donors and infertility patients.

Journal: Human reproduction (Oxford, England) 20040301

Title: N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.

Journal: The Journal of endocrinology 20040301

Title: Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.

Journal: Molecular immunology 20040201

Title: Toward the synthesis of pyroglutamate lauroyl ester: biocatalysis versus chemical catalysis.

Journal: Biotechnology letters 20040201

Title: Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain.

Journal: The international journal of biochemistry & cell biology 20040101

Title: Regulation of intermediary metabolism and water balance of insects by neuropeptides.

Journal: Annual review of entomology 20040101

Title: Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid.

Journal: Biological & pharmaceutical bulletin 20040101

Title: Stimulatory effect of PG-KII, an NK3 tachykinin receptor agonist, on isolated pancreatic acini: species-related differences.

Journal: Peptides 20040101

Title: Catalytic hydrogenation of glutamic acid.

Journal: Applied biochemistry and biotechnology 20040101

Title: Evidence that lamprey GnRH-III does not release FSH selectively in cattle.

Journal: Reproduction (Cambridge, England) 20040101

Title: A newborn infant with generalized glutathione synthetase deficiency.

Journal: The Turkish journal of pediatrics 20040101

Title: The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits growth of non-tumorigenic colonic epithelial cells.

Journal: Anticancer research 20040101

Title: Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma 20040101

Title: Pyroglutamyl-histidyl-glycine, the endogenous colon mitosis inhibitor, regulates cyclic AMP level in non-tumorigenic colonic epithelial cells.

Journal: Anticancer research 20040101

Title: [Antioxidants-induced rearrangements of actin cytoskeleton in 3T3 and 3T3-SV40 fibroblasts].

Journal: Tsitologiia 20040101

Title: 3,3',5'-triiodo-L-thyronine reduces efficiency of mRNA knockdown by antisense oligodeoxynucleotides: a study with pyroglutamyl aminopeptidase II in adenohypophysis.

Journal: Oligonucleotides 20040101

Title: Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus.

Journal: Journal of agricultural and food chemistry 20031231

Title: Magnesium supplementation does not delay disease onset or increase survival in a mouse model of familial ALS.

Journal: Journal of the neurological sciences 20031215

Title: First messenger regulation of capacitation via G protein-coupled mechanisms: a tale of serendipity and discovery.

Journal: Molecular human reproduction 20031201

Title: Thyrotropin-releasing hormone in the dorsal vagal complex stimulates hepatic blood flow in rats.

Journal: Hepatology (Baltimore, Md.) 20031201

Title: Sickle cell disease: from membrane pathophysiology to novel therapies for prevention of erythrocyte dehydration.

Journal: Journal of pediatric hematology/oncology 20031201

Title: Characterization of a circulating N-extended form of the thyrotropin-releasing hormone-like peptide pGlu-Glu-Pro amide in human plasma.

Journal: The Journal of clinical endocrinology and metabolism 20031201

Title: Substrate specificity of glutaminyl cyclases from plants and animals.

Journal: Biological chemistry 20031201

Title: Effect of chirality on the structural behaviour of hydrogen-bonded n-alkylammonium pyroglutamates in the crystalline and smectic state.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20031107

Title: Glucose acts in the CNS to regulate gastric motility during hypoglycemia.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20031101

Title: Hydrolysis of synthetic substrate, L-pyroglutamyl p-nitroanilide is catalyzed solely by pyroglutamyl aminopeptidase I in rat liver cytosol.

Journal: Biological & pharmaceutical bulletin 20031101

Title: Chemoselective nucleophilic attack on N-acyl derivatives of (S)-ethyl 4,4-dimethyl pyroglutamate (DMPG).

Journal: Organic letters 20031016

Title: Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection.

Journal: European journal of pharmacology 20031008

Title: Adipokinetic hormone inhibits the formation of energy stores and egg production in the cricket Gryllus bimaculatus.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20031001

Title: Intracellular mediators of granulysin-induced cell death.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030901

Title: Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030801

Title: Fibrosis and glycogen stores depletion induced by prolonged biliary obstruction in the rat are ameliorated by metadoxine.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20030801

Title: Pyrrolidinones derived from (S)-pyroglutamic acid: penmacric acid and analogues.

Journal: Organic & biomolecular chemistry 20030707

Title: Protective effect of central thyrotropin-releasing hormone on carbon tetrachloride-induced acute hepatocellular necrosis in rats.

Journal: Journal of hepatology 20030701

Title: Effect of pyroglutamylasparagine amide on plastic characteristics of synaptic transmission in the hippocampus.

Journal: Bulletin of experimental biology and medicine 20030701

Title: L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency.

Journal: Free radical biology & medicine 20030601

Title: Mode of action of neuropeptides from the adipokinetic hormone family.

Journal: General and comparative endocrinology 20030601

Title: Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.

Journal: Metabolism: clinical and experimental 20030601

Title: Comparison of structure-activity relations of corazonin using two different bioassay systems.

Journal: Peptides 20030601

Title: Intravenous urocortin II decreases blood pressure through CRF(2) receptor in rats.

Journal: Regulatory peptides 20030515

Title: Synthesis of cis-4-trifluoromethyl- and cis-4-difluoromethyl-l-pyroglutamic acids.

Journal: The Journal of organic chemistry 20030502

Title: [Reproductive toxicity of metadoxine in rats].

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20030501

Title: [Oleyl pyroglutamate for use as transdermal enhancer and its enhancing mechanism].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030501

Title: Inhibitory effect of L-pyroglutamate on extremophiles: correlation with growth temperature and pH.

Journal: FEMS microbiology letters 20030425

Title: Central administration of thyrotropin releasing hormone (TRH) and related peptides inhibits feeding behavior in the Siberian hamster.

Journal: Neuroreport 20030415

Title: Intravenous glucose infusion decreases intracisternal thyrotropin-releasing hormone induced vagal stimulation of gastric acid secretion in anesthetized rats.

Journal: Neuroscience letters 20030403

Title: Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (Pringle maneuver) under hypovolemic conditions.

Journal: World journal of surgery 20030401

Title: [Advances in modulation of mammalian sperm function by fertilization promoting peptide].

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 20030401

Title: Biologic activity of the tachykinins on lamb and sheep gallbladder.

Journal: Peptides 20030401

Title: Determination of the post-translational modifications of salivary acidic proline-rich proteins.

Journal: European journal of morphology 20030401

Title: Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Synthesis and reactions of a novel 3,4-didehydropyroglutamate derivative.

Journal: Chemical communications (Cambridge, England) 20030321

Title: Development and conformational analysis of a pseudoproline-containing turn mimic.

Journal: The Journal of organic chemistry 20030307

Title: The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20030301

Title: In vitro metabolism of an insect neuropeptide by homogenates of the nematode Caenorhabditis elegans.

Journal: Journal of helminthology 20030301

Title: Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator.

Journal: Protein science : a publication of the Protein Society 20030301

Title: Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.

Journal: Neuropharmacology 20030301

Title: Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats.

Journal: Journal of gastroenterology and hepatology 20030201

Title: Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels.

Journal: Journal of periodontal research 20030201

Title: Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors.

Journal: Pharmacology, biochemistry, and behavior 20030101

Title: Central administration of neuropeptide Y reduces alpha-melanocyte-stimulating hormone-induced cyclic adenosine 5'-monophosphate response element binding protein (CREB) phosphorylation in pro-thyrotropin-releasing hormone neurons and increases CREB phosphorylation in corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus.

Journal: Endocrinology 20030101

Title: Deblocking of N-terminally modified proteins.

Journal: Methods in molecular biology (Clifton, N.J.) 20030101

Title: Isolation and identification of indigestible pyroglutamyl peptides in an enzymatic hydrolysate of wheat gluten prepared on an industrial scale.

Journal: Journal of agricultural and food chemistry 20030101

Title: Effects of fertilization promoting peptide, adenosine, and pentoxifylline on thawed human sperm.

Journal: Archives of andrology 20030101

Title: Metabolism of the calcium and bioavailability of the salts of most frequent use.

Journal: Bollettino chimico farmaceutico 20030101

Title: [Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101

Title: [Effect of agents changing the intracellular level of reactive oxygen species on the cell cycle phase distribution in 3T3 and 3T3SV40 cell lines].

Journal: Tsitologiia 20030101

Title: The colon mitosis-inhibitor pyroglutamyl-histidyl-glycine alters expression of immediate-early cancer-related genes in HT-29 cells.

Journal: Anticancer research 20030101

Title: [Neuroprotective and cerebrovascular effects of GABA mimetics].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101

Title: Glucose-induced changes in the phenotype of human peritoneal mesothelial cells: effect of L-2-oxothiazolidine carboxylic acid.

Journal: American journal of nephrology 20030101

Title: Metadoxine in the treatment of acute and chronic alcoholism: a review.

Journal: International journal of immunopathology and pharmacology 20030101

Title: [Therapy with cytokines and thymic factors in a complicated case of common variable immunodeficiency].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20030101

Title: A new approach to drug therapy in non-alcoholic steatohepatitis (NASH).

Journal: The Journal of international medical research 20030101

Title: [The correlation of tolerance to cerebral ischemia and body temperature with glutathione concentration].

Journal: Biomeditsinskaia khimiia 20030101

Title: Cocaine regulates TRH-related peptides in rat brain.

Journal: Neurochemistry international 20021201

Title: The role of Ins(1,4,5)P(3) in signal transduction of the metabolic neuropeptide Mem-CC in the cetoniid beetle, Pachnoda sinuata.

Journal: Insect biochemistry and molecular biology 20021201

Title: Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20021104

Title: Leptin regulates bone formation via the sympathetic nervous system.

Journal: Cell 20021101

Title: Sensitivity of larval and adult crickets (Gryllus bimaculatus) to adipokinetic hormone.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20021101

Title: Neuropharmacodynamic evaluation of the centrally active thyrotropin-releasing hormone analogue [Leu2]TRH and its chemical brain-targeting system.

Journal: Brain research 20021018

Title: Lamprey GnRH-III acts on its putative receptor via nitric oxide to release follicle-stimulating hormone specifically.

Journal: Experimental biology and medicine (Maywood, N.J.) 20021001

Title: Activation of raphe pallidus neurons increases insulin through medullary thyrotropin-releasing hormone (TRH)-vagal pathways.

Journal: Pancreas 20021001

Title: Production of pyroglutamic acid by thermophilic lactic acid bacteria in hard-cooked mini-cheeses.

Journal: Journal of dairy science 20021001

Title: In vivo monitoring of hepatic glutathione in anesthetized rats by 13C NMR.

Journal: Magnetic resonance in medicine 20020901

Title: Thyrotropin-releasing hormone regulates the diurnal variation of pyroglutamyl aminopeptidase II activity in the male rat adenohypophysis.

Journal: European journal of endocrinology 20020901

Title: Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival.

Journal: Journal of neurochemistry 20020901

Title: Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases.

Journal: Anti-cancer drugs 20020901

Title: Clinical evaluation and changes of the respiratory epithelium function after administration of Pidotimod in Greek children with recurrent respiratory tract infections.

Journal: Minerva pediatrica 20020801

Title: Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots.

Journal: FEMS microbiology reviews 20020801

Title: Effects of dietary cholesterol on pyroglutamyl aminopeptidase activity in mouse frontal cortex, pituitary, and adrenal glands.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020801

Title: Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro.

Journal: Journal of periodontal research 20020801

Title: Effect of a fertilization-promoting peptide on the fertilizing ability and glycosidase activity in vitro of frozen-thawed spermatozoa in the pig.

Journal: Animal reproduction science 20020715

Title: Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.

Journal: Neuroscience letters 20020712

Title: Determination of the absolute configuration of 2-hydroxyglutaric acid and 5-oxoproline in urine samples by high-resolution NMR spectroscopy in the presence of chiral lanthanide complexes.

Journal: Journal of pharmaceutical and biomedical analysis 20020615

Title: Pharmacologically distinct binding sites in rat brain for [3H]thyrotropin-releasing hormone (TRH) and [3H][3-methyl-histidine(2)]TRH.

Journal: Biochemical pharmacology 20020615

Title: Stereoselective total syntheses of the racemic form and the natural enantiomer of the marine alkaloid lepadiformine via a novel N-acyliminium ion/allylsilane spirocyclization strategy.

Journal: The Journal of organic chemistry 20020614

Title: Spinal nociceptin inhibits septide but not N-methyl-D-aspartate-induced nociceptive behavior in rats.

Journal: European journal of pharmacology 20020607

Title: Pseudopeptide foldamers: the homo-oligomers of pyroglutamic acid.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20020603

Title: A possible molecular ancestor for mollusk APGWamide, insect adipokinetic hormone, and crustacean red pigment concentrating hormone.

Journal: Journal of molecular evolution 20020601

Title: Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues.

Journal: European journal of biochemistry 20020601

Title: Synthesis and biological evaluation of a novel pyroglutamyl-modified TRH analogue.

Journal: Farmaco (Societa chimica italiana : 1989) 20020601

Title: Allatostatins of the tiger prawn, Penaeus monodon (Crustacea: Penaeidea).

Journal: Peptides 20020601

Title: Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes.

Journal: Science (New York, N.Y.) 20020510

Title: Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides.

Journal: Brain research 20020510

Title: Beetles' choice--proline for energy output: control by AKHs.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20020501

Title: Selective tachykinin NK3-receptor agonists stimulate in vitro exocrine pancreatic secretion in the guinea pig.

Journal: Peptides 20020501

Title: New insights in Adipokinetic Hormone (AKH) precursor processing in Locusta migratoria obtained by capillary liquid chromatography-tandem mass spectrometry.

Journal: Peptides 20020401

Title: Dietary fatty acid composition affects aminopeptidase activities in the testes of mice.

Journal: International journal of andrology 20020401

Title: Inhibition of contact hypersensitivity reaction to picryl chloride: effect of small molecular weight peptidomimetic compounds possessing inhibitory activity against metalloproteinases.

Journal: International immunopharmacology 20020401

Title: Five- and six-membered ring opening of pyroglutamic diketopiperazine.

Journal: The Journal of organic chemistry 20020322

Title: Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

Title: Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study.

Journal: Alcoholism, clinical and experimental research 20020301

Title: Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells.

Journal: Journal of neuroendocrinology 20020301

Title: Aminopeptidases in Caenorhabditis elegans and Panagrellus redivivus: detection using peptide and non-peptide substrates.

Journal: Journal of helminthology 20020301

Title: Antidiabetic effect of a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, through CD38 dimerization and internalization.

Journal: The Journal of biological chemistry 20020215

Title: Conformationally restricted TRH analogues: constraining the pyroglutamate region.

Journal: Bioorganic & medicinal chemistry 20020201

Title: Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans.

Journal: American journal of physiology. Endocrinology and metabolism 20020201

Title: L-2-Oxothiazolidine-4-carboxylate reverses the tumour growth-promoting effect of interleukin-2 and improves the anti-tumour efficacy of biochemotherapy in mice bearing B16 melanoma liver metastases.

Journal: Melanoma research 20020201

Title: Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin.

Journal: European journal of biochemistry 20020201

Title: In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.

Journal: Archives of biochemistry and biophysics 20020115

Title: Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.

Journal: Synapse (New York, N.Y.) 20020101

Title: Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.

Journal: Molecular human reproduction 20020101

Title: Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020101

Title: Comparison of the positive and negative ion electrospray mass spectra of some small peptides containing pyroglutamate.

Journal: Rapid communications in mass spectrometry : RCM 20020101

Title: Rapid determination of underivatized pyroglutamic acid, glutamic acid, glutamine and other relevant amino acids in fermentation media by LC-MS-MS.

Journal: The Analyst 20020101

Title: Efficacy of metadoxine in the management of acute alcohol intoxication.

Journal: The Journal of international medical research 20020101

Title: [Polar constituents of the ascidia Botryllus schlosseri].

Journal: Bioorganicheskaia khimiia 20020101

Title: Selective hypersensitivity to pidolate.

Journal: Allergy 20020101

Title: Early oncogene mRNA expression in HT-29 cells treated with the endogenous colon mitosis inhibitor pyroglutamyl-histidyl-glycine.

Journal: Anticancer research 20020101

Title: [Sterility of males determined by functional features of the mouse spermatozoa bearing t-complex].

Journal: Ontogenez 20020101

Title: [Pidotimod in recurring respiratory infection in children with allergic rhinitis, asthma, or both conditions].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20020101

Title: [Effect of a drug composition containing pyroglutamic acid and pyrrolidone on the cerebral circulation].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20020101

Title: L-2-oxothiazolidine-4-carboxylate: an agent that modulates lipopolysaccharide-induced peritonitis in rats.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20020101

Title: Synthesis of ( 2S, 4S)-4-phenylamino-5-oxoproline derivatives.

Journal: Amino acids 20020101

Title: Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.

Journal: Redox report : communications in free radical research 20020101

Title: Use of sodium borohydride to detect acyl-phosphate linkages in enzyme reactions.

Journal: Methods in enzymology 20020101

Title: [Glutathione in therapy].

Journal: Postepy higieny i medycyny doswiadczalnej 20020101

Title: Methacrylate derivatives incorporating pyroglutamic acid.

Journal: Biomacromolecules 20020101

Title: [Organic acid disorders: cerebral organic acidemia].

Journal: Ryoikibetsu shokogun shirizu 20020101

Title: Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids.

Journal: The Journal of organic chemistry 20011228

Title: Hormonal stimulation of proline synthesis in the fat body of the fruit beetle, Pachnoda sinuata, is calcium dependent.

Journal: Insect biochemistry and molecular biology 20011201

Title: In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP).

Journal: Peptides 20011201

Title: (L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1.

Journal: BJU international 20011201

Title: L-pyroglutamic acid inhibits energy production and lipid synthesis in cerebral cortex of young rats in vitro.

Journal: Neurochemical research 20011201

Title: Efferent projections of ProTRH neurons in the ventrolateral periaqueductal gray.

Journal: Brain research 20011123

Title: Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture.

Journal: Pharmacological research 20011101

Title: The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC.

Journal: Journal of cell science 20011001

Title: Synthesis of lipids in the fat body of Gryllus bimaculatus: age-dependency and regulation by adipokinetic hormone.

Journal: Archives of insect biochemistry and physiology 20010801

Title: Modulators with convergent cellular actions elicit distinct circuit outputs.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601

Title: Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.

Journal: Journal of leukocyte biology 20010601

Title: Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.

Journal: Journal of the American College of Nutrition 20010601

Title: Massive 5-oxoprolinuria with normal 5-oxoprolinase and glutathione synthetase activities.

Journal: Journal of inherited metabolic disease 20010601

Title: Red pigment-concentrating hormone induces a calcium-mediated retraction of distal retinal pigments in the crayfish.

Journal: Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 20010601

Title: Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis.

Journal: The Biochemical journal 20010515

Title: Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010501

Title: Removal of N-terminal blocking groups from proteins.

Journal: Current protocols in protein science 20010501

Title: Effect of high population density environment on skin barrier function in mice.

Journal: Journal of dermatological science 20010401

Title: Rapid down regulation of pyroglutamyl peptidase II activity by arachidonic acid in primary cultures of adenohypophyseal cells.

Journal: Life sciences 20010316

Title: Potent cytolytic response by a CD8+ CTL clone to multiple peptides from the same protein in association with an allogeneic class I MHC molecule.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010301

Title: Calcitonin, angiotensin II and FPP significantly modulate mouse sperm function.

Journal: Molecular human reproduction 20010301

Title: In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles.

Journal: The Journal of investigative dermatology 20010301

Title: Monoamine release by neurons of a primitive nervous system: an amperometric study.

Journal: Journal of neurochemistry 20010301

Title: Conformational study of insect adipokinetic hormones using NMR constrained molecular dynamics.

Journal: Journal of computer-aided molecular design 20010301

Title: Regulatory responses to an oral D-glutamate load: formation of D-pyrrolidone carboxylic acid in humans.

Journal: American journal of physiology. Endocrinology and metabolism 20010201

Title: Angiotensin II is involved in nitric oxide synthase and cyclo-oxygenase inhibition-induced leukocyte-endothelial cell interactions in vivo.

Journal: British journal of pharmacology 20010201

Title: Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain.

Journal: Neurobiology of disease 20010201

Title: Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds.

Journal: Experimental hematology 20010201

Title: Hereditary non-spherocytic haemolytic anaemia due to red blood cell glutathione synthetase deficiency in four unrelated patients from Spain: clinical and molecular studies.

Journal: British journal of haematology 20010201

Title: Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster.

Journal: American journal of physiology. Cell physiology 20010201

Title: A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity).

Journal: Bioscience, biotechnology, and biochemistry 20010201

Title: Intracellular Mg2+ diffusion within isolated rat skeletal muscle fibers.

Journal: Biophysical chemistry 20010131

Title: The role of calcium in the activation of glycogen phosphorylase in the fat body of the fruit beetle, Pachnoda sinuata, by hypertrehalosaemic hormone.

Journal: Biochimica et biophysica acta 20010115

Title: Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20010108

Title: Vagal-enteric interface: vagal activation-induced expression of c-Fos and p-CREB in neurons of the upper gastrointestinal tract and pancreas.

Journal: The Anatomical record 20010101

Title: Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101

Title: Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats.

Journal: Pharmacology 20010101

Title: Fertilization promoting peptide--a possible regulator of sperm function in vivo.

Journal: Vitamins and hormones 20010101

Title: Therapeutic strategies for prevention of sickle cell dehydration.

Journal: Blood cells, molecules & diseases 20010101

Title: Effect of the hemoregulatory peptide (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 and MIP-1alpha is reduced in bone marrow cultures from patients with chronic myeloid leukemia (CML).

Journal: Stem cells (Dayton, Ohio) 20010101

Title: [Metadoxyl in combined treatment of alcohol damage to the liver].

Journal: Klinicheskaia meditsina 20010101

Title: Survivability of biomolecules during extraterrestrial delivery: new results on pyrolysis of amino acids and poly-amino acids.

Journal: Advances in space research : the official journal of the Committee on Space Research (COSPAR) 20010101

Title: Limited heat-shock protein 72 induction in Caco-2 cells by L-glutamine.

Journal: Digestion 20010101

Title: Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor.

Journal: In vivo (Athens, Greece) 20010101

Title: Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin.

Journal: Archives of medical research 20010101

Title: A novel cis-peptide bond motif inducing beta-turn type VI. The synthesis of enkephalin analogues modified with 4-aminopyroglutamic acid.

Journal: Acta biochimica Polonica 20010101

Title: A third active AKH is present in the pyrgomorphid grasshoppers Phymateus morbillosus and Dictyophorus spumans.

Journal: Insect biochemistry and molecular biology 20001101

Title: Synthesis and characterization of water-soluble silver(I) complexes with L-histidine (H2his) and (S)-(-)-2-pyrrolidone-5-carboxylic acid (H2pyrrld) showing a wide spectrum of effective antibacterial and antifungal activities. Crystal structures of chiral helical polymers [Ag(Hhis)]n and ([Ag(Hpyrrld)]2)n in the solid state.

Journal: Inorganic chemistry 20000724

Title: A new member of the AKH/RPCH family that stimulates locomotory activity in the firebug, Pyrrhocoris apterus (Heteroptera).

Journal: Insect biochemistry and molecular biology 20000601

Title: Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.

Journal: Melanoma research 20000401

Title: Synthesis and in vitro anti-HIV activity in human monocyte-derived macrophages of 2-oxothiazolidine-4(R)-carboxylic acid derivatives.

Journal: Journal of medicinal chemistry 19991118

Title: The hemoregulatory peptide pEEDCK may inhibit stem cell proliferation via hydropathic binding to antisense sequence motifs in interleukin-11 and other growth factors.

Journal: Molecular pharmacology 19991001

Title: Tissue-specific regulation of glutathione homeostasis and the activator protein-1 (AP-1) response in the rat conceptus.

Journal: Biochemical pharmacology 19990515

Title: The growth-inhibiting epidermal pentapeptide, pyroGlu-glu-asp-ser-GlyOH, inhibits growth and alters gene expression in non-transformed NC3H10 and transformed TC3H10 fibroblasts.

Journal: Oncology reports 19990101

Title: Activated granulocytes oxidize the endogenous stem cell inhibitory peptide pGlu-Glu-Asp-Cys-Lys (pEEDCK) to the stimulatory dimer: a redox-mediated mechanism for demand-induced hematopoietic regulation.

Journal: Experimental hematology 19980801

Title: Analogs of Manduca adipokinetic hormone tested in a bioassay and in a receptor-binding assay.

Journal: Peptides 19980101

Title: Isolation and characterization of Melanoplus sanguinipes adipokinetic hormone: a new member of the AKH/RPCH family.

Journal: Biochemical and biophysical research communications 19971029

Title: Protective effects of L-2-oxothiazolidine-4-carboxylate treatment on cyclophosphamide-induced cystitis in rats.

Journal: The Journal of urology 19970501

Title: L-2-oxothiazolidine-4-carboxylic acid inhibits human immunodeficiency virus type 1 replication in mononuclear phagocytes and lymphocytes.

Journal: Clinical and diagnostic laboratory immunology 19970501

Title: No. 302, a newly synthesized [pGlu4,Cyt6]AVP(4-9) analogue, prevents the disruption of avoidance behavior.

Journal: Behavioural brain research 19970201

Title: Reduction in the duration of myelotoxicity associated with radioimmunotherapy with infusions of the hemoregulatory peptide, HP5b in mice.

Journal: International journal of cancer 19970127

Title: Distinct sequences of AKH/RPCH family members in beetle (Scarabaeus-species) corpus cardiacum contain three aromatic amino acid residues.

Journal: Biochemical and biophysical research communications 19970103

Title: Hyperprolinaemia caused by novel members of the adipokinetic hormone/red pigment-concentrating hormone family of peptides isolated from corpora cardiaca of onitine beetles.

Journal: The Biochemical journal 19970101

Title: Insect neuropeptide leucopyrokinin analogues--synthesis and antinociceptive effect in rats.

Journal: Polish journal of pharmacology 19970101

Title: Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis.

Journal: FEBS letters 19961216

Title: Hydrolytic cleavage of pyroglutamyl-peptide bond. III. A highly selective cleavage in 70% methanesulfonic acid.

Journal: Chemical & pharmaceutical bulletin 19961101

Title: Probing the V1a vasopressin receptor binding site with pyroglutamate-substituted linear antagonists.

Journal: Neuropeptides 19960201

Title: Supplementation with L-2-oxothiazolidine-4-carboxylic acid, a cysteine precursor, does not protect against lipid peroxidation in puromycin aminonucleoside-induced nephropathy.

Journal: Experimental nephrology 19960101

Title: Amino acid sequence of CAP2b, an insect cardioacceleratory peptide from the tobacco hawkmoth Manduca sexta.

Journal: FEBS letters 19950911

Title: Primary structure of a novel neuropeptide isolated from the corpora cardiaca of periodical cicadas having adipokinetic and hypertrehalosemic activities.

Journal: Insect biochemistry and molecular biology 19950901

Title: [A granulopoiesis inhibitor. Synthesis and biological activity].

Journal: Bioorganicheskaia khimiia 19950601

Title: Inhibitory peptides in hematopoiesis.

Journal: Experimental hematology 19950601

Title: L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain.

Journal: Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 19950201

Title: Isolation and primary structures of neuropeptides of the AKH/RPCH family from various termite species.

Journal: Peptides 19950101

Title: Isolation of two AKH-related peptides from cicadas.

Journal: Archives of insect biochemistry and physiology 19950101

Title: Zinc and the mitosis-inhibitory epidermal pentapeptide (EPP) form a stimulatory chelated dimer.

Journal: Archives of dermatological research 19950101

Title: Biologically active pyroglutamyl N-terminal oligopeptides: parts of larger molecules?

Journal: Physiological chemistry and physics and medical NMR 19950101

Title: Regional distribution and immunocytological localization of red pigment concentrating hormone in the crayfish eyestalk.

Journal: General and comparative endocrinology 19940901

Title: A novel adipokinetic octapeptide found in the damselflies Pseudagrion inconspicuum and Ischnura senegalensis.

Journal: The Biochemical journal 19940901

Title: Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.

Journal: AIDS research and human retroviruses 19940801

Title: Metamorphosin A: a novel peptide controlling development of the lower metazoan Hydractinia echinata (Coelenterata, Hydrozoa).

Journal: Developmental biology 19940601

Title: Role of oxygen free radicals in cocaine-induced vascular disruption in mice.

Journal: Teratology 19940301

Title: A novel peptide in the AKH/RPCH family isolated from the corpora cardiaca of the Emperor dragonfly, Anax imperator.

Journal: Peptides 19940101

Title: Beta-receptor blockade by propranolol modifies the effect of the inhibitory, endogenous epidermal pentapeptide on epidermal cell flux at the G2-M transition but not at the G1-S transition.

Journal: Epithelial cell biology 19940101

Title: Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide.

Journal: Carcinogenesis 19931201

Title: The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) increases levels of inositol 1,4,5-trisphosphate in the tentacle retractor muscle of Helix aspersa.

Journal: Experimental physiology 19931101

Title: Isolation, identification and synthesis of locustapyrokinin II from Locusta migratoria, another member of the FXPRL-amide peptide family.

Journal: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 19930901

Title: Pre-CFU-S quiescence and stem cell exhaustion after cytostatic drug treatment: protective effects of the inhibitory peptide pGlu-Glu-Asp-Cys-Lys (pEEDCK).

Journal: Blood 19930401

Title: Audiogenic seizures in magnesium-deficient mice: effects of magnesium pyrrolidone-2-carboxylate, magnesium acetyltaurinate, magnesium chloride and vitamin B-6.

Journal: Magnesium research 19930301

Title: Isolation of Antho-RFamide related peptides from the eyestalks of blue crab.

Journal: Comparative biochemistry and physiology. B, Comparative biochemistry 19930201

Title: Primary structure of a cardioactive neuropeptide from the tobacco hawkmoth, Manduca sexta.

Journal: FEBS letters 19921123

Title: Hydra head activator peptide has trophic activity for eukaryotic neurons.

Journal: Brain research. Developmental brain research 19920724

Title: Isolation of the neuropeptide less than Glu-Trp-Leu-Lys-Gly-Arg-Phe-NH2 (Pol-RFamide II) from the hydromedusa Polyorchis penicillatus.

Journal: Biochemical and biophysical research communications 19920316

Title: Isolation and primary structure of a novel pheromonotropic neuropeptide structurally related to leucopyrokinin from the armyworm larvae, Pseudaletia separata.

Journal: Biochemical and biophysical research communications 19920131

Title: Modulation of KB and A431 cell adhesion by epidermal growth inhibitory pentapeptide.

Journal: Virchows Archiv. B, Cell pathology including molecular pathology 19920101

Title: Effect of combination treatment with analogs of luteinizing hormone-releasing hormone (LH-RH) or somatostatin and 5-fluorouracil on pancreatic cancer in hamsters.

Journal: International journal of cancer 19910909

Title: A unique charged tyrosine-containing member of the adipokinetic hormone/red-pigment-concentrating hormone peptide family isolated and sequenced from two beetle species.

Journal: The Biochemical journal 19910501

Title: Primary structure of the precursor for the sea anemone neuropeptide Antho-RFamide (less than Glu-Gly-Arg-Phe-NH2).

Journal: Proceedings of the National Academy of Sciences of the United States of America 19910315

Title: Protection from arabinofuranosylcytosine and n-mustard-induced myelotoxicity using hemoregulatory peptide pGlu-Glu-Asp-Cys-Lys monomer and dimer.

Journal: Blood 19910315

Title: The adipokinetic neuropeptide of Mantodea. Sequence elucidation and evolutionary relationships.

Journal: Biological chemistry Hoppe-Seyler 19910301

Title: The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, inhibits growth of rat hepatoma cells in vitro.

Journal: Carcinogenesis 19910201

Title: Isolation and structure elucidation of a novel adipokinetic hormone (Lom-AKH-III) from the glandular lobes of the corpus cardiacum of the migratory locust, Locusta migratoria.

Journal: European journal of biochemistry 19910130

Title: Inhibitory epidermal pentapeptide modulates proliferation and differentiation of transformed mouse epidermal cells in vitro.

Journal: Virchows Archiv. B, Cell pathology including molecular pathology 19910101

Title: The epidermal pentapeptide pyroGlu-Glu-Asp-Ser-GlyOH inhibits murine hair growth in vivo and in vitro.

Journal: Dermatologica 19910101

Title: Degradation of adipokinetic hormone family peptides by a circulating endopeptidase in the insect Manduca sexta.

Journal: Peptides 19910101

Title: An efficient chemical-enzymatic synthesis of LHRH N-terminal pentapeptide.

Journal: Biomedica biochimica acta 19910101

Title: Inhibition of hematopoietic stem cell proliferation by hemoregulatory peptide pyroGlu-Glu-Asp-Cys-Lys (pEEDCK) provides protection against short-term neutropenia and long-term damage.

Journal: Annals of the New York Academy of Sciences 19910101

Title: The use of haemoregulatory peptides (pEEDCK monomer and dimer) for reduction of cytostatic drug induced haemopoietic damage.

Journal: Cancer treatment reviews 19900901

Title: The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide.

Journal: The Biochemical journal 19900715

Title: Isolation and structure of a novel charged member of the red-pigment-concentrating hormone-adipokinetic hormone family of peptides isolated from the corpora cardiaca of the blowfly Phormia terraenovae (Diptera).

Journal: The Biochemical journal 19900715

Title: The putative ancestral peptide of the adipokinetic/red-pigment-concentrating hormone family isolated and sequenced from a dragonfly.

Journal: Biological chemistry Hoppe-Seyler 19900601

Title: TRH-extended peptides in the olfactory lobe are formed by incomplete cleavage at pairs of arginine residues in the TRH prohormone.

Journal: FEBS letters 19900521

Title: Norvaline2-TRH: binding to TRH receptors in rat brain homogenates.

Journal: European journal of pharmacology 19900503

Title: Prevention of hematotoxic side effects of cytostatic drugs in mice by a synthetic hemoregulatory peptide.

Journal: Cancer research 19900115

Title: Mouse epidermal cell renewal after topical treatment with different concentrations of the epidermal peptide pyroGlu-Glu-Asp-Ser-GlyOH.

Journal: Virchows Archiv. B, Cell pathology including molecular pathology 19900101

Title: UVB-induced epidermal hyperproliferation is modified by a single, topical treatment with a mitosis inhibitory epidermal pentapeptide.

Journal: The Journal of investigative dermatology 19900101

Title: The primary structure of the hypertrehalosemic neuropeptide from tenebrionid beetles: a novel member of the AKH/RPCH family.

Journal: Peptides 19900101

Title: Pentapeptide inhibitor of epidermal mitosis: production and responsiveness in cultures of normal, transformed and neoplastic human keratinocytes.

Journal: Carcinogenesis 19891201

Title: Suppressive biological activity of a synthetic pentapeptide on highly enriched human and murine marrow hematopoietic progenitors: synergism with recombinant human tumor necrosis factor-alpha and interferon-gamma.

Journal: Experimental hematology 19891001

Title: Biosynthesis of adipokinetic hormones (AKHs): further characterization of precursors and identification of novel products of processing.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19890301

Title: Enhancement of methylnitrosourea-induced skin tumorigenesis and carcinogenesis in hairless mice by pretreatment with a mitosis-inhibiting epidermal pentapeptide.

Journal: Carcinogenesis 19890201

Title: Controversies in TRH biosynthesis and strategies towards the identification of a TRH precursor.

Journal: Annals of the New York Academy of Sciences 19890101

Title: The metabolic neuropeptides of the corpus cardiacum from the potato beetle and the American cockroach are identical.

Journal: Peptides 19890101

Title: Isolation of less than Glu-Ser-Leu-Arg-Trp-NH2, a novel neuropeptide from sea anemones.

Journal: Brain research 19880301

Title: [A synthetic peptide from Helix aspersa raises arterial pressure in rats].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 19880101

Title: Primary sequence analysis by fast atom bombardment mass spectrometry of a peptide with adipokinetic activity from the corpora cardiaca of the cricket Gryllus bimaculatus.

Journal: Biochemical and biophysical research communications 19871231

Title: Effect of pyroglutamic acid stereoisomers on ECS and scopolamine-induced memory disruption and brain acetylcholine levels in the rat.

Journal: Pharmacological research communications 19871201

Title: Inhibitory activity of a synthetic pentapeptide on leukaemic myelopoiesis both in vitro and in vivo in rats.

Journal: European journal of haematology 19871101

Title: The actions of FMRFamide-like peptides on visceral and somatic muscles of the snail Helix aspersa.

Journal: The Journal of experimental biology 19870901

Title: Sequential processing reactions in the formation of hormone amides.

Journal: European journal of biochemistry 19870817

Title: Isolation and structure of an epidermal mitosis inhibiting pentapeptide.

Journal: Biochemical and biophysical research communications 19870814

Title: Specific processing of the thyrotropin-releasing prohormone in rat brain and spinal cord.

Journal: European journal of biochemistry 19870615

Title: Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19870601

Title: Active fragments and analogs of the insect neuropeptide leucopyrokinin: structure-function studies.

Journal: Biochemical and biophysical research communications 19860630

Title: Processing of the thyrotropin releasing hormone (TRH) precursor in Xenopus skin and bovine hypothalamus: evidence for the existence of extended forms of TRH.

Journal: Regulatory peptides 19860501

Title: Primary structure of gonadotropin-releasing hormone from lamprey brain.

Journal: The Journal of biological chemistry 19860415

Title: Isolation and primary structure of a peptide from the corpora cardiaca of Heliothis zea with adipokinetic activity.

Journal: Biochemical and biophysical research communications 19860313

Title: Immunohistochemical localization in the rat brain of the precursor for thyrotropin-releasing hormone.

Journal: Science (New York, N.Y.) 19850913

Title: [Synthesis of cyclic and non-cyclic tachykinin partial sequences. 2. Synthesis of the homocyclic substance P(6-11) hexapeptide].

Journal: Die Pharmazie 19850801

Title: Rohdei-litorin: a new peptide from the skin of Phyllomedusa rohdei.

Journal: FEBS letters 19850311

Title: Arterial blood pressure response in conscious rabbits to administration of C-terminal fragment of substance P into the cerebral ventricles, intravenously and intragastrically.

Journal: Arzneimittel-Forschung 19850101

Title: The isolation and characterization of an insulin-releasing tetrapeptide from urines of patients with lipoatrophic diabetes.

Journal: Biochemical and biophysical research communications 19840718

Title: C-terminal amidation of neuropeptides. Gly-Lys-Arg extension an efficient precursor of C-terminal amide.

Journal: FEBS letters 19840213

Title: Cleavage of Trimeresurus flavoviridis phospholipase A2 with cyanogen bromide: sequence of the short peptide fragment and formation of a noncovalently bonded complex from the fragments.

Journal: Journal of biochemistry 19810801

Title: An approach to the elucidation of metabolic breakdown products of the luteinizing hormone-releasing hormone.

Journal: Journal of medicinal chemistry 19810601

Title: Preparation of 3H-[3-M3-His2]TRH as an improved ligand for TRH receptors.

Journal: Neuroendocrinology 19810501

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Tags:149-87-1 Molecular Formula|149-87-1 MDL|149-87-1 SMILES|149-87-1 Dl-pyroglutamic acid