Home Amines 15018-66-3
15018-66-3,MFCD00092016
Catalog No.:AA001MB8

15018-66-3 | Quinazolin-4-ylamine

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250mg
98%
in stock  
$25.00   $18.00
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1g
98%
in stock  
$52.00   $36.00
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5g
98%
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$162.00   $114.00
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25g
98%
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$535.00   $375.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001MB8
Chemical Name:
Quinazolin-4-ylamine
CAS Number:
15018-66-3
Molecular Formula:
C8H7N3
Molecular Weight:
145.1613
MDL Number:
MFCD00092016
SMILES:
Nc1ncnc2c1cccc2
NSC Number:
288012
Properties
Computed Properties
 
Complexity:
137  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
1.3  

Upstream Synthesis Route

[1]Tetrahedron,2011,vol.67,#26,p.4852-4857

[1]Tetrahedron,2011,vol.67,#26,p.4852-4857

[1]TetrahedronLetters,2004,vol.45,#22,p.4241-4243

[2]TetrahedronLetters,2009,vol.50,#40,p.5631-5632

[1]JournalofMedicinalChemistry,2000,vol.43,#11,p.2227-2238

[1]JournalofHeterocyclicChemistry,2006,vol.43,#4,p.913-916

Downstream Synthesis Route

[1]JournaloftheChemicalSociety,1949,p.1354

[2]JournaloftheChemicalSociety,1949,p.1354

[1]JournaloftheChemicalSociety,1949,p.1354

[2]JournaloftheChemicalSociety,1949,p.1354

[1]JournalofHeterocyclicChemistry,1982,vol.19,p.1285-1287

15018-66-3    70-23-5    128036-83-9   
ethylimidazo<1,2-c>quinazoline-3-carboxylate 

[1]JournalofHeterocyclicChemistry,1990,vol.27,p.421-425

15018-66-3    70-11-1   
4-Amino-1-(2-oxo-2-phenyl-ethyl)-quinazolin-1-ium;bromide 

[1]TetrahedronLetters,1985,vol.26,p.2905-2908

Literature

Title: Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: potential PET imaging agents for tumor detection.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: (E)-2-[2-(4-Chloro-benzyl-idene)hydrazin-1-yl]-4-{[3-(dimethyl-aza-nium-yl)prop-yl]amino}-quinazolin-1-ium bis-(perchlorate).

Journal: Acta crystallographica. Section E, Structure reports online 20120501

Title: Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase.

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: Investigation of a novel molecular descriptor for the lead optimization of 4-aminoquinazolines as vascular endothelial growth factor receptor-2 inhibitors: application for quantitative structure-activity relationship analysis in lead optimization.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method.

Journal: PloS one 20110101

Title: Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.

Journal: BMC cancer 20110101

Title: Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists.

Journal: Bioorganic & medicinal chemistry 20090101

Title: Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase.

Journal: Bioorganic & medicinal chemistry 20080815

Title: ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1.

Journal: Current neuropharmacology 20080301

Title: Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives.

Journal: Bioorganic & medicinal chemistry 20071015

Title: The novel Src kinase inhibitor M475271 inhibits VEGF-induced vascular endothelial-cadherin and beta-catenin phosphorylation but increases their association.

Journal: Journal of pharmacological sciences 20060901

Title: Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts.

Journal: Molecular cancer therapeutics 20060801

Title: Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients.

Journal: Cancer investigation 20060101

Title: A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration.

Journal: Journal of pharmacological sciences 20050601

Title: SRC tyrosine kinase inhibitor, m475271, suppresses subcutaneous growth and production of lung metastasis via inhibition of proliferation, invasion, and vascularization of human lung adenocarcinoma cells.

Journal: Clinical & experimental metastasis 20050101

Title: Efficient synthesis of 4-aminoquinazoline and thieno[3,2-d]pyrimidin-4-ylamine derivatives by microwave irradiation.

Journal: Organic letters 20041209

Title: A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists.

Journal: European journal of medicinal chemistry 20041201

Title: Synthesis and alpha 1-adrenoceptor antagonistic activity of some 4-amino-5,7-dimethyl-2-(substituted) aminopyrido (2,3-d) pyrimidines.

Journal: Arzneimittel-Forschung 20020101

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