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1628838-42-5,MFCD30534393
Catalog No.:AA00ASQX

1628838-42-5 | RAF709

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$15.00   $11.00
- +
5mg
97%
in stock  
$37.00   $26.00
- +
10mg
97%
in stock  
$55.00   $39.00
- +
25mg
97%
in stock  
$92.00   $64.00
- +
50mg
97%
in stock  
$151.00   $106.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ASQX
Chemical Name:
RAF709
CAS Number:
1628838-42-5
Molecular Formula:
C28H29F3N4O4
Molecular Weight:
542.5495
MDL Number:
MFCD30534393
SMILES:
Cc1ncc(cc1c1cnc(c(c1)N1CCOCC1)OC1CCOCC1)NC(=O)c1cccc(c1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
793  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4  

Downstream Synthesis Route

[1]Nishiguchi,GiseleA.;Rico,Alice;Tanner,Huw;Aversa,RobertJ.;Taft,BenjaminR.;Subramanian,Sharadha;Setti,Lina;Burger,MatthewT.;Wan,Lifeng;Tamez,Victoriano;Smith,Aaron;Lou,Yan;Barsanti,PaulA.;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Dix,Ina;Tellew,JohnE.;Huang,Shenlin;MathewsGriner,LesleyA.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Ma,Sylvia;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Jansen,JohannaM.;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Lees,Emma;Shao,Wenlin;Stuart,DarrinD.;Dillon,MichaelP.;Ramurthy,Savithri[JournalofMedicinalChemistry,2017,vol.60,#12,p.4869-4881]

CASUnavailable 
  1800399-74-9    1628838-42-5 

[1]Nishiguchi,GiseleA.;Rico,Alice;Tanner,Huw;Aversa,RobertJ.;Taft,BenjaminR.;Subramanian,Sharadha;Setti,Lina;Burger,MatthewT.;Wan,Lifeng;Tamez,Victoriano;Smith,Aaron;Lou,Yan;Barsanti,PaulA.;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Dix,Ina;Tellew,JohnE.;Huang,Shenlin;MathewsGriner,LesleyA.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Ma,Sylvia;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Jansen,JohannaM.;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Lees,Emma;Shao,Wenlin;Stuart,DarrinD.;Dillon,MichaelP.;Ramurthy,Savithri[JournalofMedicinalChemistry,2017,vol.60,#12,p.4869-4881]

[2]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

[1]Nishiguchi,GiseleA.;Rico,Alice;Tanner,Huw;Aversa,RobertJ.;Taft,BenjaminR.;Subramanian,Sharadha;Setti,Lina;Burger,MatthewT.;Wan,Lifeng;Tamez,Victoriano;Smith,Aaron;Lou,Yan;Barsanti,PaulA.;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Dix,Ina;Tellew,JohnE.;Huang,Shenlin;MathewsGriner,LesleyA.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Ma,Sylvia;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Jansen,JohannaM.;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Lees,Emma;Shao,Wenlin;Stuart,DarrinD.;Dillon,MichaelP.;Ramurthy,Savithri[JournalofMedicinalChemistry,2017,vol.60,#12,p.4869-4881]

[2]Ramurthy,Savithri;Taft,BenjaminR.;Aversa,RobertJ.;Barsanti,PaulA.;Burger,MatthewT.;Lou,Yan;Nishiguchi,GiseleA.;Rico,Alice;Setti,Lina;Smith,Aaron;Subramanian,Sharadha;Tamez,Victoriano;Tanner,Huw;Wan,Lifeng;Hu,Cheng;Appleton,BrentA.;Mamo,Mulugeta;Tandeske,Laura;Tellew,JohnE.;Huang,Shenlin;Yue,Qin;Chaudhary,Apurva;Tian,Hung;Iyer,Raman;Hassan,A.Quamrul;MathewsGriner,LesleyA.;LaBonte,LauraR.;Cooke,VesselinaG.;VanAbbema,Anne;Merritt,Hanne;Gampa,Kalyani;Feng,Fei;Yuan,Jing;Mishina,Yuji;Wang,Yingyun;Haling,JacobR.;Vaziri,Sepideh;Hekmat-Nejad,Mohammad;Polyakov,Valery;Zang,Richard;Sethuraman,Vijay;Amiri,Payman;Singh,Mallika;Sellers,WilliamR.;Lees,Emma;Shao,Wenlin;Dillon,MichaelP.;Stuart,DarrinD.[JournalofMedicinalChemistry,2020,vol.63,#5,p.2013-2027]

884495-22-1   
N-(2-methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-3,3′-bipyridin-5-yl)-3-(trifluoromethyl)benzamide 

[1]JournalofMedicinalChemistry,2017,vol.60,p.4869-4881

[2]JournalofMedicinalChemistry,2020,vol.63,p.2013-2027

Literature

Title: Reactions of cytosine and cytidine with O-substituted hydroxylamines.

Journal: Journal of the Chemical Society. Perkin transactions 1 19750101

Title: Nishiguchi GA, et al. Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-,3'-bipyridin-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. J Med Chem. 2017 Jun 22;60(12):4869-4881.

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