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[1]BioorganicandMedicinalChemistry,2011,vol.19,p.6949-6965
[1]BioorganicandMedicinalChemistry,2011,vol.19,p.6949-6965
[1]BioorganicandMedicinalChemistry,2011,vol.19,p.6949-6965
Title: Neurotrophins and cholinergic enzyme regulated by calpain-2: New insights into neuronal apoptosis induced by polybrominated diphenyl ether-153.
Journal: Toxicology letters 20180701
Title: Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153.
Journal: Toxicology letters 20170805
Title: Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.
Journal: Toxicology and applied pharmacology 20160101
Title: Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines.
Journal: Molecules (Basel, Switzerland) 20140217
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Journal: Journal of medicinal chemistry 20130214
Title: Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells.
Journal: BMC pharmacology & toxicology 20130101
Title: Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations.
Journal: Neurochemistry international 20121101
Title: Roscovitine is a novel agent that can be used for the activation of porcine oocytes reconstructed with adult cutaneous or fetal fibroblast cell nuclei.
Journal: Theriogenology 20121101
Title: Use of ATP analogs to inhibit HIV-1 transcription.
Journal: Virology 20121010
Title: Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20121001
Title: In vivo vs. in vitro models for studying the effects of elevated temperature on the GV-stage oocyte, subsequent developmental competence and gene expression.
Journal: Animal reproduction science 20121001
Title: Can ex vivo evaluation (testing) predict the sensitivity of CLL cells to therapy with purine analogs in conjunction with an alkylating agent? A comparison of in vivo and ex vivo responses to treatment.
Journal: Medical oncology (Northwood, London, England) 20120901
Title: Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition.
Journal: Cell cycle (Georgetown, Tex.) 20120901
Title: Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822
Title: Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120808
Title: [Ca2+]i rise at in vitro maturation in bovine cumulus-oocyte complexes.
Journal: Molecular reproduction and development 20120601
Title: Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells.
Journal: Molecular medicine reports 20120501
Title: Domain III regulates N-type (CaV2.2) calcium channel closing kinetics.
Journal: Journal of neurophysiology 20120401
Title: Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells.
Journal: Molecular medicine reports 20120401
Title: Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321
Title: Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease.
Journal: The Journal of biological chemistry 20120302
Title: Small molecule screening identifies targetable zebrafish pigmentation pathways.
Journal: Pigment cell & melanoma research 20120301
Title: LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients.
Journal: PLoS genetics 20120301
Title: γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.
Journal: The Journal of biological chemistry 20120224
Title: Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils.
Journal: Journal of cellular physiology 20120201
Title: Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells.
Journal: Amino acids 20120201
Title: Roscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation.
Journal: The Journal of pharmacology and experimental therapeutics 20120201
Title: Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
Journal: Nature neuroscience 20120201
Title: The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer.
Journal: British journal of cancer 20120131
Title: GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons.
Journal: Pharmacological research 20120101
Title: Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: recent progress and future prospects.
Journal: Nephron. Clinical practice 20120101
Title: Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis.
Journal: PloS one 20120101
Title: Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer.
Journal: Oncotarget 20120101
Title: Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites.
Journal: Frontiers in microbiology 20120101
Title: Pharmacodynamic modelling of biomarker data in oncology.
Journal: ISRN pharmacology 20120101
Title: Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
Journal: PloS one 20120101
Title: R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae.
Journal: Molecular medicine (Cambridge, Mass.) 20120101
Title: Enhancement of carboplatin- and quercetin-induced cell death by roscovitine is Akt dependent and p53 independent in hepatoma cells.
Journal: Integrative cancer therapies 20111201
Title: Design, synthesis and biological study of novel pyrido[2,3-d]pyrimidine as anti-proliferative CDK2 inhibitors.
Journal: European journal of medicinal chemistry 20111201
Title: Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.
Journal: Nature medicine 20111201
Title: Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription.
Journal: Cell death & disease 20111201
Title: Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Journal: Bioorganic & medicinal chemistry 20111115
Title: Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.
Journal: European journal of medicinal chemistry 20111101
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology 20111101
Title: Small molecule cyclin-dependent kinase inhibitors protect against neuronal cell death in the ischemic-reperfused rat retina.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20111001
Title: Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases.
Journal: Angiogenesis 20110901
Title: Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.
Journal: British journal of cancer 20110712
Title: Transcriptional modulation of apoptosis regulators by roscovitine and related compounds.
Journal: Apoptosis : an international journal on programmed cell death 20110701
Title: Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1.
Journal: Apoptosis : an international journal on programmed cell death 20110701
Title: Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.
Journal: Bioorganic & medicinal chemistry letters 20110701
Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
Journal: Journal of medicinal chemistry 20110623
Title: New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).
Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20110601
Title: Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.
Journal: European journal of medicinal chemistry 20110601
Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
Journal: European journal of medicinal chemistry 20110601
Title: Meiotic inhibition of bovine oocytes in medium supplemented with a serum replacer and hormones: effects on meiosis progression and developmental capacity.
Journal: Zygote (Cambridge, England) 20110501
Title: Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and cumulus-enclosed oocytes in vitro.
Journal: Zygote (Cambridge, England) 20110501
Title: Raman micro-spectroscopic analysis of cultured HCT116 colon cancer cells in the presence of roscovitine.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110501
Title: Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells.
Journal: Apoptosis : an international journal on programmed cell death 20110501
Title: Treatment with a cyclin-dependent kinase inhibitor, seliciclib, is effective in reducing glomerular macrophage numbers and the severity of established experimental glomerulonephritis.
Journal: Nephrology (Carlton, Vic.) 20110501
Title: A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer.
Journal: Oncogene 20110428
Title: Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.
Journal: Journal of medicinal chemistry 20110428
Title: Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells.
Journal: FEBS letters 20110420
Title: Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells.
Journal: Bioorganic & medicinal chemistry 20110415
Title: Androgen stimulates endothelial cell proliferation via an androgen receptor/VEGF/cyclin A-mediated mechanism.
Journal: American journal of physiology. Heart and circulatory physiology 20110401
Title: Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells.
Journal: Journal of cellular biochemistry 20110401
Title: Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110401
Title: High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
Journal: PLoS neglected tropical diseases 20110401
Title: Immunodetection of retinoblastoma-related protein and its phosphorylated form in interphase and mitotic alfalfa cells.
Journal: Journal of experimental botany 20110301
Title: Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells.
Journal: Journal of cellular biochemistry 20110301
Title: p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
Journal: Oncogene 20110203
Title: 6-Hydroxydopamine-induced PC12 cell death is mediated by MEF2D down-regulation.
Journal: Neurochemical research 20110201
Title: Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.
Journal: Bioorganic & medicinal chemistry 20110101
Title: Liposarcoma: molecular genetics and therapeutics.
Journal: Sarcoma 20110101
Title: Effect of anti-estrogen combined with roscovitine, a selective CDK inhibitor, on human breast cancer cells differing in expression of ER.
Journal: Journal of experimental therapeutics & oncology 20110101
Title: Tamoxifen enhances the anti-proliferative effect of roscovitine, a selective cyclin-dependent kinase inhibitor, on human ER-positive human breast cancer cells.
Journal: Journal of experimental therapeutics & oncology 20110101
Title: WEE1 inhibition sensitizes osteosarcoma to radiotherapy.
Journal: BMC cancer 20110101
Title: Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.
Journal: BMC research notes 20110101
Title: Differential inhibitor sensitivity between human kinases VRK1 and VRK2.
Journal: PloS one 20110101
Title: Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells.
Journal: Breast cancer research : BCR 20110101
Title: Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling.
Journal: PloS one 20110101
Title: Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.
Journal: PloS one 20110101
Title: The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.
Journal: Genetics research international 20110101
Title: Targeting apoptosis signaling pathways for anticancer therapy.
Journal: Frontiers in oncology 20110101
Title: A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Journal: Journal of medicinal chemistry 20101223
Title: Time course of in vitro maturation of compact cumulus horse oocytes after roscovitine-induced meiotic inhibition: effects on the coordination between nuclear and cytoplasmic maturation.
Journal: Reproduction in domestic animals = Zuchthygiene 20101201
Title: Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies.
Journal: European journal of cancer (Oxford, England : 1990) 20101201
Title: Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.
Journal: The Journal of biological chemistry 20101112
Title: Regulation of C/EBPbeta1 by Ras in mammary epithelial cells and the role of C/EBPbeta1 in oncogene-induced senescence.
Journal: Oncogene 20101111
Title: ATP-binding cassette B1 transports seliciclib (R-roscovitine), a cyclin-dependent kinase inhibitor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Journal: Cancer biology & therapy 20101101
Title: Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types.
Journal: British journal of cancer 20101026
Title: Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: preparation, characterization and in vitro cytotoxicity.
Journal: European journal of medicinal chemistry 20101001
Title: Chemotherapy-induced genotoxic stress promotes sensitivity to natural killer cell cytotoxicity by enabling missing-self recognition.
Journal: Cancer research 20100915
Title: CDK5 serves as a major control point in neurotransmitter release.
Journal: Neuron 20100909
Title: Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.
Journal: Haematologica 20100901
Title: Parthenogenetic development of domestic cat oocytes treated with ionomycin, cycloheximide, roscovitine and strontium.
Journal: Theriogenology 20100901
Title: Cyclin-dependent kinase activity controls the onset of the HCMV lytic cycle.
Journal: PLoS pathogens 20100901
Title: Use of a Piezo drill for intracytoplasmic sperm injection into cattle oocytes activated with ionomycin associated with roscovitine.
Journal: Reproduction in domestic animals = Zuchthygiene 20100801
Title: Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model.
Journal: Hippocampus 20100801
Title: Probing the probes: fitness factors for small molecule tools.
Journal: Chemistry & biology 20100625
Title: Strong inhibition of replicative DNA synthesis in the developing rat cerebral cortex and glioma cells by roscovitine.
Journal: Investigational new drugs 20100601
Title: Microtubule distribution in somatic cell nuclear transfer bovine embryos following control of nuclear remodeling type.
Journal: Journal of veterinary science 20100601
Title: Effect of cdk5 antagonist on L-dopa-induced dyskinesias in a rat model of Parkinson's disease.
Journal: The International journal of neuroscience 20100601
Title: 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity.
Journal: Journal of medicinal chemistry 20100513
Title: Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.
Journal: Gastroenterology 20100501
Title: Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor.
Journal: Molecular endocrinology (Baltimore, Md.) 20100501
Title: Graphic rule for drug metabolism systems.
Journal: Current drug metabolism 20100501
Title: Targeting the cell cycle and the PI3K pathway: a possible universal strategy to reactivate innate tumor suppressor programmes in cancer cells.
Journal: International journal of oncology 20100401
Title: Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex.
Journal: The Journal of biological chemistry 20100219
Title: Low-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100215
Title: Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish.
Journal: Journal of leukocyte biology 20100201
Title: A novel roscovitine derivative potently induces G1-phase arrest in platelet-derived growth factor-BB-activated vascular smooth muscle cells.
Journal: Molecular pharmacology 20100201
Title: Cyclin-dependent kinase 5 phosphorylates endothelial nitric oxide synthase at serine 116.
Journal: Hypertension (Dallas, Tex. : 1979) 20100201
Title: Editorial: Maintaining the balance--fishing for drugs to treat persistent neutrophilic inflammation.
Journal: Journal of leukocyte biology 20100201
Title: C-fin: a cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone-disrupting chemicals.
Journal: Environmental toxicology and chemistry 20100201
Title: Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells.
Journal: Neuroscience letters 20100118
Title: Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100101
Title: Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation.
Journal: The Journal of biological chemistry 20100101
Title: RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion.
Journal: The Journal of biological chemistry 20100101
Title: R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis.
Journal: Journal of cellular biochemistry 20100101
Title: Healthy clocks, healthy body, healthy mind.
Journal: Trends in cell biology 20100101
Title: Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100101
Title: The radiosensitising effect of olomoucine derived synthetic cyclin-dependent kinase inhibitors.
Journal: Neoplasma 20100101
Title: Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment.
Journal: BMC cancer 20100101
Title: Role of senescence and mitotic catastrophe in cancer therapy.
Journal: Cell division 20100101
Title: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors.
Journal: AIDS research and therapy 20100101
Title: In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance.
Journal: Journal of innate immunity 20100101
Title: Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage.
Journal: PloS one 20100101
Title: R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair.
Journal: Molecular cancer 20100101
Title: Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models.
Journal: PloS one 20100101
Title: Application of new drugs in chronic lymphocytic leukemia.
Journal: Mediterranean journal of hematology and infectious diseases 20100101
Title: Wortmannin potentiates roscovitine-induced growth inhibition in human solid tumor cells by repressing PI3K/Akt pathway.
Journal: Cancer letters 20091228
Title: Regulation of serotonin 1B receptor by glycogen synthase kinase-3.
Journal: Molecular pharmacology 20091201
Title: Seliciclib in malignancies.
Journal: Expert opinion on investigational drugs 20091201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091101
Title: Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.
Journal: Cancer research 20091015
Title: Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.
Journal: Molecular pharmacology 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages.
Journal: American journal of physiology. Cell physiology 20090901
Title: Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo.
Journal: Cell cycle (Georgetown, Tex.) 20090901
Title: Roscovitine triggers apoptosis in B-cell chronic lymphocytic leukemia cells with similar efficiency as combinations of conventional purine analogs with cyclophosphamide.
Journal: Annals of the New York Academy of Sciences 20090801
Title: Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?
Journal: Annals of the New York Academy of Sciences 20090801
Title: Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells.
Journal: Annals of the New York Academy of Sciences 20090801
Title: Monitoring of long-term effects of resveratrol on cell cycle progression of human HeLa cells after administration of a single dose.
Journal: Annals of the New York Academy of Sciences 20090801
Title: Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib.
Journal: Chronobiology international 20090801
Title: The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface.
Journal: Journal of cellular physiology 20090701
Title: Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat.
Journal: Glia 20090601
Title: Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine.
Journal: Journal of cellular biochemistry 20090601
Title: Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601
Title: Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Journal: Blood 20090507
Title: Off-target decoding of a multitarget kinase inhibitor by chemical proteomics.
Journal: Chembiochem : a European journal of chemical biology 20090504
Title: The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers.
Journal: Cell cycle (Georgetown, Tex.) 20090501
Title: Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration.
Journal: Nature cell biology 20090501
Title: PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.
Journal: Nature cell biology 20090501
Title: QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090415
Title: Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Journal: Cellular signalling 20090401
Title: Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment.
Journal: Journal of cellular biochemistry 20090401
Title: Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB.
Journal: Cell proliferation 20090401
Title: Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401
Title: Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors.
Journal: The international journal of biochemistry & cell biology 20090301
Title: Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats.
Journal: Pain 20090301
Title: Role of the HIV-1 positive elongation factor P-TEFb and inhibitors thereof.
Journal: Mini reviews in medicinal chemistry 20090301
Title: Development of cell-cycle inhibitors for cancer therapy.
Journal: Current oncology (Toronto, Ont.) 20090301
Title: Advances in the pathogenesis and treatment of polycystic kidney disease.
Journal: Current opinion in nephrology and hypertension 20090301
Title: The role of Cdk5 in retinoic acid-induced apoptosis of cervical cancer cell line.
Journal: The Chinese journal of physiology 20090227
Title: Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215
Title: Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.
Journal: Journal of medicinal chemistry 20090212
Title: Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A.
Journal: Brain research 20090203
Title: Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.
Journal: Pharmaceutical research 20090201
Title: Cell cycle synchronization of canine ear fibroblasts for somatic cell nuclear transfer.
Journal: Zygote (Cambridge, England) 20090201
Title: The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation.
Journal: The Journal of physiology 20090201
Title: Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.
Journal: International journal of cancer 20090115
Title: Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects.
Journal: Arthritis research & therapy 20090101
Title: The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status.
Journal: BMC cancer 20090101
Title: Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.
Journal: Retrovirology 20090101
Title: You never know: Cdk inhibitors as anti-cancer drugs.
Journal: Cell cycle (Georgetown, Tex.) 20081215
Title: Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells.
Journal: British journal of cancer 20081202
Title: Action of resveratrol alone or in combination with roscovitine, a CDK inhibitor, on cell cycle progression in human HL-60 leukemia cells.
Journal: Biochemical pharmacology 20081201
Title: Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells.
Journal: Biochemical pharmacology 20081201
Title: Small-molecule Bcl-2 antagonists as targeted therapy in oncology.
Journal: Current oncology (Toronto, Ont.) 20081201
Title: Human cytomegalovirus IE1 protein enhances herpes simplex virus type 1-induced syncytial formation in U373MG cells.
Journal: Journal of Korean medical science 20081201
Title: Synthesis and biological evaluation of diversely substituted indolin-2-ones.
Journal: European journal of medicinal chemistry 20081101
Title: Restoration of renal function in zebrafish models of ciliopathies.
Journal: Pediatric nephrology (Berlin, Germany) 20081101
Title: Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells.
Journal: Neurobiology of disease 20081101
Title: The histone-deacetylase inhibitor MS-275 and the CDK-inhibitor CYC-202 promote anti-tumor effects in hepatoma cell lines.
Journal: Oncology reports 20081101
Title: CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Journal: Oncogene 20081002
Title: (R)-roscovitine, a cyclin-dependent kinase inhibitor, enhances tonic GABA inhibition in rat hippocampus.
Journal: Neuroscience 20081002
Title: Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.
Journal: Cancer research 20081001
Title: Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells.
Journal: The Journal of biological chemistry 20080912
Title: Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells.
Journal: World journal of gastroenterology 20080907
Title: N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine.
Journal: Molecular cancer therapeutics 20080901
Title: Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Journal: Journal of medicinal chemistry 20080828
Title: NMR screening for lead compounds using tryptophan-mutated proteins.
Journal: Journal of medicinal chemistry 20080828
Title: Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent.
Journal: Toxicology and applied pharmacology 20080815
Title: The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes.
Journal: Journal of pineal research 20080801
Title: Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.
Journal: European journal of medicinal chemistry 20080701
Title: Flow cytometric cell cycle analysis of cultured brown bear fibroblast cells.
Journal: Cell biology international 20080701
Title: Effect of serum starvation and chemical inhibitors on cell cycle synchronization of canine dermal fibroblasts.
Journal: Theriogenology 20080701
Title: Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080701
Title: Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition.
Journal: Current biology : CB 20080603
Title: Effect of seliciclib (CYC202, R-roscovitine) on lymphocyte alloreactivity and acute kidney allograft rejection in rat.
Journal: Transplantation 20080527
Title: The separation of antagonist from agonist effects of trisubstituted purines on CaV2.2 (N-type) channels.
Journal: Journal of neurochemistry 20080501
Title: cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
Journal: The EMBO journal 20080409
Title: Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080401
Title: Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety.
Journal: Journal of natural products 20080401
Title: Chemical activation of in vitro matured dromedary camel (Camelus dromedarius) oocytes: optimization of protocols.
Journal: Theriogenology 20080315
Title: Nuclear maturation kinetics and in vitro embryo development of cattle oocytes prematured with butyrolactone I combined or not combined with roscovitine.
Journal: Animal reproduction science 20080303
Title: Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (R-roscovitine) in vitro and in vivo.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080301
Title: Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.
Journal: Biology of reproduction 20080201
Title: Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.
Journal: Cellular and molecular life sciences : CMLS 20080201
Title: Cyclin-dependent kinase inhibitor roscovitine induces cell cycle arrest and apoptosis in rabbit retinal pigment epithelial cells.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080201
Title: Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching.
Journal: The Journal of biological chemistry 20080104
Title: A quantitative analysis of kinase inhibitor selectivity.
Journal: Nature biotechnology 20080101
Title: Better understanding of ADPKD results in potential new treatment options: ready for the cure?
Journal: Journal of nephrology 20080101
Title: Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.
Journal: Retrovirology 20080101
Title: Synchronisation of canine germinal vesicle stage oocytes prior to in vitro maturation alters the kinetics of nuclear progression during subsequent resumption of meiosis.
Journal: Reproduction, fertility, and development 20080101
Title: Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells.
Journal: Drug design, development and therapy 20080101
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218
Title: The selectivity of protein kinase inhibitors: a further update.
Journal: The Biochemical journal 20071215
Title: A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein.
Journal: Journal of cellular biochemistry 20071215
Title: The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis.
Journal: Cell cycle (Georgetown, Tex.) 20071215
Title: Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.
Journal: The Journal of biological chemistry 20071214
Title: Effect of the Cdk-inhibitor roscovitine on mouse hematopoietic progenitors in vivo and in vitro.
Journal: Cancer chemotherapy and pharmacology 20071101
Title: Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.
Journal: Journal of neuroscience research 20071101
Title: Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection.
Journal: Cell death and differentiation 20071101
Title: Inhibition of farnesyl protein transferase sensitizes human MCF-7 breast cancer cells to roscovitine-mediated cell cycle arrest.
Journal: Journal of cellular biochemistry 20071015
Title: Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis.
Journal: Journal of neurochemistry 20070901
Title: Roscovitine in B-chronic lymphocytic leukemia cells: high apoptosis-inducing efficacy and synergism with alemtuzumab independent of the patients' pretreatment status.
Journal: Haematologica 20070901
Title: Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells.
Journal: British journal of cancer 20070828
Title: Prime time for polycystic kidney disease: does one shot of roscovitine bring the cure?
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801
Title: Production of cloned horse foals using roscovitine-treated donor cells and activation with sperm extract and/or ionomycin.
Journal: Reproduction (Cambridge, England) 20070801
Title: A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo.
Journal: The journal of physiological sciences : JPS 20070801
Title: Role of cyclin-dependent kinase 5 in capsaicin-induced cough.
Journal: European journal of pharmacology 20070702
Title: Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress.
Journal: Molecular endocrinology (Baltimore, Md.) 20070701
Title: 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.
Journal: Oncogene 20070607
Title: Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202.
Journal: Endocrine-related cancer 20070601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070601
Title: Role of roscovitine and IBMX on kinetics of nuclear and cytoplasmic maturation of bovine oocytes in vitro.
Journal: Animal reproduction science 20070501
Title: The effects of the CDK inhibitor seliciclib alone or in combination with cisplatin in human uterine sarcoma cell lines.
Journal: Gynecologic oncology 20070501
Title: Anti-proliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3.
Journal: Journal of cellular biochemistry 20070501
Title: Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus.
Journal: Arthritis and rheumatism 20070501
Title: [Research on cyclin-dependent kinase inhibitors: state of the art and perspective].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070501
Title: Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells.
Journal: Journal of cellular biochemistry 20070415
Title: AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.
Journal: The Journal of biological chemistry 20070309
Title: Studies on cell-cycle synchronization in the asexual erythrocytic stages of Plasmodium falciparum.
Journal: Parasitology 20070301
Title: Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells.
Journal: Journal of cellular biochemistry 20070301
Title: Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activity.
Journal: Cancer chemotherapy and pharmacology 20070201
Title: Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein cdk5.
Journal: Experimental and molecular pathology 20070201
Title: A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days.
Journal: British journal of cancer 20070115
Title: Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
Journal: Cancer research 20070115
Title: Study of the inhibition of cyclin-dependent kinases with roscovitine and indirubin-3'-oxime from molecular dynamics simulations.
Journal: Journal of molecular modeling 20070101
Title: A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport.
Journal: Endocrinology 20070101
Title: Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine.
Journal: Cellular & molecular biology letters 20070101
Title: Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas.
Journal: Leukemia & lymphoma 20070101
Title: Seliciclib (CYC202; r-roscovitine) in combination with cytotoxic agents in human uterine sarcoma cell lines.
Journal: Anticancer research 20070101
Title: Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells.
Journal: Annals of the New York Academy of Sciences 20070101
Title: Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex.
Journal: Retrovirology 20070101
Title: DrugScoreRNA--knowledge-based scoring function to predict RNA-ligand interactions.
Journal: Journal of chemical information and modeling 20070101
Title: p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels.
Journal: BMC nephrology 20070101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070101
Title: Imaging immediate-early and strict-late promoter activity during oncolytic herpes simplex virus type 1 infection and replication in tumors.
Journal: Gene therapy 20061201
Title: A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061201
Title: p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation.
Journal: Cancer research 20061201
Title: Prevention of p53 degradation in human MCF-7 cells by proteasome inhibitors does not mimic the action of roscovitine.
Journal: Annals of the New York Academy of Sciences 20061201
Title: Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor.
Journal: Cancer research 20061115
Title: 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Journal: Journal of medicinal chemistry 20061102
Title: Analysis of different factors influencing the intracytoplasmic sperm injection (ICSI) yield in pigs.
Journal: Theriogenology 20061101
Title: Holding immature equine oocytes in the absence of meiotic inhibitors: effect on germinal vesicle chromatin and blastocyst development after intracytoplasmic sperm injection.
Journal: Theriogenology 20060901
Title: Enhanced activation of Ca2+/calmodulin-dependent protein kinase II upon downregulation of cyclin-dependent kinase 5-p35.
Journal: Journal of neuroscience research 20060901
Title: Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis.
Journal: Nature medicine 20060901
Title: Replication-dependent DNA damage response triggered by roscovitine induces an uncoupling of DNA replication proteins.
Journal: Cell cycle (Georgetown, Tex.) 20060901
Title: Phenol red reduces ROSC mediated cell cycle arrest and apoptosis in human MCF-7 cells.
Journal: Journal of cellular biochemistry 20060815
Title: Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors.
Journal: Molecular neurobiology 20060801
Title: Cellular stress increases RGS2 mRNA and decreases RGS4 mRNA levels in SH-SY5Y cells.
Journal: Neuroscience letters 20060724
Title: (R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to nutlin-3-induced apoptosis.
Journal: Experimental cell research 20060715
Title: Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons.
Journal: Life sciences 20060627
Title: The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle.
Journal: The Journal of endocrinology 20060601
Title: Production of horse foals via direct injection of roscovitine-treated donor cells and activation by injection of sperm extract.
Journal: Reproduction (Cambridge, England) 20060601
Title: The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction.
Journal: The European journal of neuroscience 20060601
Title: Interaction energies for the purine inhibitor roscovitine with cyclin-dependent kinase 2: correlated ab initio quantum-chemical, DFT and empirical calculations.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060524
Title: In vitro maturation and fertilization of porcine oocytes after a 48 h culture in roscovitine, an inhibitor of p34cdc2/cyclin B kinase.
Journal: Animal reproduction science 20060501
Title: Developmental competence of bovine oocytes after specific inhibition of MPF kinase activity: effect of estradiol supplementation and follicle size.
Journal: Animal reproduction science 20060501
Title: Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics.
Journal: The Journal of biological chemistry 20060317
Title: Deregulation of cyclin-dependent kinase 2 activity correlates with UVC-induced apoptosis in Chinese hamster ovary cells.
Journal: Journal of cellular biochemistry 20060301
Title: Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes.
Journal: Reproduction (Cambridge, England) 20060301
Title: Selectivity and potency of cyclin-dependent kinase inhibitors.
Journal: The AAPS journal 20060301
Title: Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein.
Journal: Expert opinion on investigational drugs 20060101
Title: Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics.
Journal: Current pharmaceutical design 20060101
Title: NORs and their transcription competence during the cell cycle.
Journal: Folia biologica 20060101
Title: Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes.
Journal: Toxicology 20051215
Title: Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication.
Journal: AIDS (London, England) 20051202
Title: Molecular models of protein kinase 6 from Plasmodium falciparum.
Journal: Journal of molecular modeling 20051201
Title: Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy.
Journal: Kidney international 20051201
Title: [New strategy for the treatment of multiple myeloma].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20051201
Title: Roscovitine modulates DNA repair and senescence: implications for combination chemotherapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051115
Title: Caspase 8/10 are not mediating apoptosis in neuroblastoma cells treated with CDK inhibitory drugs.
Journal: European journal of pharmacology 20051107
Title: A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.
Journal: The Journal of biological chemistry 20051104
Title: Roscovitine triggers excitotoxicity in cultured granule neurons by enhancing glutamate release.
Journal: Molecular pharmacology 20051101
Title: Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells.
Journal: Molecular cancer therapeutics 20051101
Title: Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo.
Journal: Cancer research 20051015
Title: Vitrification of calf oocytes: effects of maturation stage and prematuration treatment on the nuclear and cytoskeletal components of oocytes and their subsequent development.
Journal: Molecular reproduction and development 20051001
Title: Cyclin A2-CDK2 regulates embryonic gene activation in 1-cell mouse embryos.
Journal: Developmental biology 20051001
Title: Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells.
Journal: International journal of molecular medicine 20051001
Title: Roscovitine targets, protein kinases and pyridoxal kinase.
Journal: The Journal of biological chemistry 20050902
Title: Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.
Journal: The Journal of biological chemistry 20050902
Title: Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.
Journal: Biophysical journal 20050901
Title: Role of the cell cycle in the pathobiology of central nervous system trauma.
Journal: Cell cycle (Georgetown, Tex.) 20050901
Title: Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells.
Journal: Cancer research 20050901
Title: Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity.
Journal: The Journal of biological chemistry 20050812
Title: Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma.
Journal: Blood 20050801
Title: Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.
Journal: Cellular and molecular life sciences : CMLS 20050801
Title: Inhibiting MAP kinase activity prevents calcium transients and mitosis entry in early sea urchin embryos.
Journal: The Journal of biological chemistry 20050701
Title: In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20050701
Title: Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis.
Journal: The Journal of biological chemistry 20050701
Title: In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050701
Title: Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Journal: Cancer research 20050615
Title: A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.
Journal: Blood 20050601
Title: Birth of piglets after transferring of in vitro-produced embryos pre-matured with R-roscovitine.
Journal: Reproduction (Cambridge, England) 20050601
Title: Implication of cyclin-dependent kinase 5 in the development of psychological dependence on and behavioral sensitization to morphine.
Journal: Journal of neurochemistry 20050601
Title: Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism.
Journal: Neuron 20050519
Title: Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050511
Title: Drugging cell cycle kinases in cancer therapy.
Journal: Current drug targets 20050501
Title: Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420
Title: c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413
Title: Recent progress in the discovery and development of cyclin-dependent kinase inhibitors.
Journal: Expert opinion on investigational drugs 20050401
Title: Development and validation of a liquid chromatography and tandem mass spectrometry method for determination of roscovitine in plasma and urine samples utilizing on-line sample preparation.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325
Title: p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.
Journal: Journal of cell science 20050315
Title: Limitation of podocyte proliferation improves renal function in experimental crescentic glomerulonephritis.
Journal: Kidney international 20050301
Title: A small molecule-kinase interaction map for clinical kinase inhibitors.
Journal: Nature biotechnology 20050301
Title: Mechanism of CDK5/p25 binding by CDK inhibitors.
Journal: Journal of medicinal chemistry 20050210
Title: Mycophenolate mofetil and roscovitine decrease cyclin expression and increase p27(kip1) expression in anti Thy1 mesangial proliferative nephritis.
Journal: Clinical and experimental immunology 20050201
Title: Contribution of high p34cdc2 kinase activity to premature chromosome condensation of injected somatic cell nuclei in rat oocytes.
Journal: Reproduction (Cambridge, England) 20050201
Title: Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response.
Journal: Cancer research 20050201
Title: Antiviral activity of CYC202 in HIV-1-infected cells.
Journal: The Journal of biological chemistry 20050128
Title: Maintenance of meiotic arrest in bovine oocytes using the S-enantiomer of roscovitine: effects on maturation, fertilization and subsequent embryo development in vitro.
Journal: Reproduction (Cambridge, England) 20050101
Title: Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.
Journal: Molecular cancer therapeutics 20050101
Title: Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse.
Journal: Molecular cancer therapeutics 20050101
Title: Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats.
Journal: Acta pharmacologica Sinica 20050101
Title: Blockage of cyclin cdk's, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: evidence for interactive effects of flavopiridol, LY 294002, roscovitine,wortmannin and UCN-01.
Journal: Anticancer research 20050101
Title: Role of cyclin-dependent kinase 5 and its activator P35 in local axon and growth cone stabilization.
Journal: Neuroscience 20050101
Title: Cdk inhibitory nucleoside analogs prevent transcription from viral genomes.
Journal: Nucleosides, nucleotides & nucleic acids 20050101
Title: GTP-dependent secretion from neutrophils is regulated by Cdk5.
Journal: The Journal of biological chemistry 20041224
Title: A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint.
Journal: Cancer research 20041215
Title: Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain.
Journal: Molecular pharmacology 20041201
Title: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Journal: American journal of physiology. Cell physiology 20041201
Title: Several signaling pathways are involved in the control of cattle oocyte maturation.
Journal: Molecular reproduction and development 20041201
Title: Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus.
Journal: Journal of cell science 20041201
Title: E2F4 deficiency promotes drug-induced apoptosis.
Journal: Cancer biology & therapy 20041201
Title: Molecular models of cyclin-dependent kinase 1 complexed with inhibitors.
Journal: Biochemical and biophysical research communications 20041112
Title: Transition of G1 to early S phase may be required for zinnia mesophyll cells to trans-differentiate to tracheary elements.
Journal: Planta 20041101
Title: Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.
Journal: International journal of oncology 20041101
Title: Endogenous regulators of protein phosphatase-1 during mouse oocyte development and meiosis.
Journal: Reproduction (Cambridge, England) 20041101
Title: Repression of G0/G1 traverse in human fibroblasts exposed to low levels of ionizing radiation.
Journal: The Journal of biological chemistry 20041015
Title: Regulation of histone acetylation during meiotic maturation in mouse oocytes.
Journal: Molecular reproduction and development 20041001
Title: Identification of tyrosine hydroxylase as a physiological substrate for Cdk5.
Journal: Journal of neurochemistry 20041001
Title: Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons.
Journal: European journal of pharmacology 20040924
Title: Effect of prematuration, meiosis activating sterol and enriched maturation medium on the nuclear maturation and competence to development of calf oocytes.
Journal: Theriogenology 20040915
Title: Retinoid-dependent mRNA expression and poly-(A) contents in bovine oocytes meiotically arrested and/or matured in vitro.
Journal: Molecular reproduction and development 20040901
Title: Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.
Journal: The American journal of pathology 20040901
Title: P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
Journal: Cancer research 20040901
Title: Intrathecal cdk5 inhibitor, roscovitine, attenuates morphine antinociceptive tolerance in rats.
Journal: Acta pharmacologica Sinica 20040801
Title: Meiotic inhibition with different cyclin-dependent kinase inhibitors in bovine oocytes and its effects on maturation and embryo development.
Journal: Zygote (Cambridge, England) 20040801
Title: Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis.
Journal: The Journal of biological chemistry 20040709
Title: The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.
Journal: Biochemical and biophysical research communications 20040702
Title: Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats.
Journal: The Journal of biological chemistry 20040521
Title: The human nuclear SRcyp is a cell cycle-regulated cyclophilin.
Journal: The Journal of biological chemistry 20040521
Title: Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons.
Journal: Biochemical pharmacology 20040515
Title: Analysis of CDK2 active-site hydration: a method to design new inhibitors.
Journal: Proteins 20040501
Title: Cell differentiation, caspase inhibition, and macromolecular synthesis blockage, but not BCL-2 or BCL-XL proteins, protect SH-SY5Y cells from apoptosis triggered by two CDK inhibitory drugs.
Journal: Experimental cell research 20040415
Title: Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.
Journal: Bioorganic & medicinal chemistry letters 20040405
Title: TBP-associated factor 1 overexpression induces tolerance to Doxorubicin in confluent H9c2 cells by an increase in cdk2 activity and cyclin E expression.
Journal: Molecular and cellular biochemistry 20040401
Title: Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts.
Journal: The Journal of biological chemistry 20040326
Title: Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators.
Journal: Blood 20040315
Title: Viral and cellular kinases are potential antiviral targets and have a central role in varicella zoster virus pathogenesis.
Journal: Biochimica et biophysica acta 20040311
Title: Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line.
Journal: Oncogene 20040304
Title: Antiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: a cell cycle-related mechanism.
Journal: Neurochemistry international 20040301
Title: Roscovitine, a cyclin-dependent kinase inhibitor, prevents replication of varicella-zoster virus.
Journal: Journal of virology 20040301
Title: Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis.
Journal: Molecular cancer therapeutics 20040301
Title: Analysis of roscovitine using novel high performance liquid chromatography and UV-detection method: pharmacokinetics of roscovitine in rat.
Journal: Journal of pharmaceutical and biomedical analysis 20040204
Title: Protection of renal cells from cisplatin toxicity by cell cycle inhibitors.
Journal: American journal of physiology. Renal physiology 20040201
Title: Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5.
Journal: Journal of cellular biochemistry 20040201
Title: Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration.
Journal: Neuron 20040122
Title: Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.
Journal: Biochemical pharmacology 20040115
Title: The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death.
Journal: Cell cycle (Georgetown, Tex.) 20040101
Title: A novel approach to develop anti-HIV drugs: adapting non-nucleoside anticancer chemotherapeutics.
Journal: Antiviral research 20040101
Title: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
Journal: Cancer research 20040101
Title: [Antiproliferative effect of bcl-2 gene does not concern the control of mitotic events].
Journal: Tsitologiia 20040101
Title: Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells.
Journal: Nutrition and cancer 20040101
Title: Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.
Journal: Oncology 20040101
Title: Cell cycle arrest induced in human breast cancer cells by cyclin-dependent kinase inhibitors: a comparison of the effects exerted by roscovitine and olomoucine.
Journal: Polish journal of pharmacology 20040101
Title: Divergent roles of GSK3 and CDK5 in APP processing.
Journal: Biochemical and biophysical research communications 20031226
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