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187164-19-8,MFCD00953915
Catalog No.:AA003RAX

187164-19-8 | 2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile

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250mg
>98.0%(HPLC)(N)
in stock  
$68.00   $48.00
- +
1g
>98.0%(HPLC)(N)
in stock  
$181.00   $127.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003RAX
Chemical Name:
2-[(2E,4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-(1H-imidazol-1-yl)acetonitrile
CAS Number:
187164-19-8
Molecular Formula:
C14H9Cl2N3S2
Molecular Weight:
354.2774
MDL Number:
MFCD00953915
SMILES:
N#C/C(=C\1/SC[C@H](S1)c1ccc(cc1Cl)Cl)/n1cncc1
Properties
Properties
 
BP:
499.1°C at 760 mmHg  
Form:
Solid  
MP:
>85ºC (subl.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
476  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ZHEJIANGEASTASIAPHARMACEUTICALSCOLTD-CN105541813,2016,ALocationinpatent:Paragraph0066;0067;0068;0069;0070;0071;0072;0073

[1]CurrentPatentAssignee:ZHEJIANGEASTASIAPHARMACEUTICALSCOLTD-CN105541813,2016,ALocationinpatent:Paragraph0098;0099

[1]CurrentPatentAssignee:ZHEJIANGEASTASIAPHARMACEUTICALSCOLTD-CN105541813,2016,ALocationinpatent:Paragraph0102;0103;

75-15-0   
(1S)-1-(2,4-dichlorophenyl)ethyl1,2-bismethanesulfonate 
  98873-55-3   
luliconazole 

[1]Patent:KR2016/61542,2016,A.Locationinpatent:Paragraph0042;0043

CASUnavailable 
  187164-21-2    1240249-76-6    187164-19-8 

[1]CurrentPatentAssignee:PERMIRAHOLDINGSLIMITED-WO2017/108972,2017,A1Locationinpatent:Page/Pagecolumn39

Literature

Title: Antimycotics suppress the Malassezia extract-induced production of CXC chemokine ligand 10 in human keratinocytes.

Journal: The Journal of dermatology 20140201

Title: Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes.

Journal: Journal of dermatological science 20130901

Title: Childhood tinea incognito caused by Trichophyton mentagrophytes var. interdigitale mimicking pustular psoriasis.

Journal: Pediatric dermatology 20110101

Title: Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model.

Journal: Medical mycology 20100501

Title: In vitro antifungal activities of luliconazole, a new topical imidazole.

Journal: Medical mycology 20090101

Title: [Fungicidal activity of liranaftate against dermatophytes].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101

Title: Allergic contact dermatitis from luliconazole.

Journal: Contact dermatitis 20070501

Title: Allergic contact dermatitis from luliconazole: implication of the dithioacetal structure.

Journal: Acta dermato-venereologica 20070101

Title: [Pharmacological and clinical properties of luliconazole (Lulicon Cream 1%, Lulicon Solution 1%), a novel topical antifungal agent].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060501

Title: In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20040801

Title: In vitro activity of novel imidazole antifungal agent NND-502 against Malassezia species.

Journal: International journal of antimicrobial agents 20030301

Title: Achievement of complete mycological cure by topical antifungal agent NND-502 in guinea pig model of tinea pedis.

Journal: Microbiology and immunology 20030101

Title: Efficacy of NND-502, a novel imidazole antimycotic agent, in experimental models of Candida albicans and Aspergillus fumigatus infections.

Journal: International journal of antimicrobial agents 19990801

Title: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent.

Journal: Antimicrobial agents and chemotherapy 19980401

Title: Hiroyasu Koga, et al. Short-term therapy with luliconazole, a novel topical antifungal imidazole, in guinea pig models of tinea corporis and tinea pedis. Antimicrob Agents Chemother. 2012 Jun;56(6):3138-43.

Title: Hiroyasu Koga, et al. In vitro antifungal activities of luliconazole, a new topical imidazole. Med Mycol. 2009;47(6):640-7.

Title: LUZU (luliconazole) Cream, 1% for topical use

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