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199986-75-9,MFCD06411412
Catalog No.:AA002CF1

199986-75-9 | CVT-313

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$29.00   $21.00
- +
5mg
98%
in stock  
$73.00   $51.00
- +
10mg
98%
in stock  
$109.00   $76.00
- +
25mg
98%
in stock  
$183.00   $128.00
- +
50mg
98%
in stock  
$237.00   $166.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002CF1
Chemical Name:
CVT-313
CAS Number:
199986-75-9
Molecular Formula:
C20H28N6O3
Molecular Weight:
400.4747
MDL Number:
MFCD06411412
SMILES:
OCCN(c1nc(NCc2ccc(cc2)OC)c2c(n1)n(cn2)C(C)C)CCO
Properties
Computed Properties
 
Complexity:
471  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
1.6  

Downstream Synthesis Route
111-42-2    203436-13-9   
Cdk2inhibitorIII 

[1]BioorganicandMedicinalChemistryLetters,1997,vol.7,p.2697-2702

[1]Schow,StevenR.;Mackman,RichardL.;Blum,CheriL.;Brooks,Eric;Horsma,AmyG.;Joly,Alison;Kerwar,SureshS.;Lee,Gavin;Shiffman,Dov;Nelson,MarekG.;Wang,Xingbo;Wick,MichaelM.;Zhang,Xiaoming;Lum,RobertT.[BioorganicandMedicinalChemistryLetters,1997,vol.7,#21,p.2697-2702]

CASUnavailable 
  199986-75-9 

[1]Schow,StevenR.;Mackman,RichardL.;Blum,CheriL.;Brooks,Eric;Horsma,AmyG.;Joly,Alison;Kerwar,SureshS.;Lee,Gavin;Shiffman,Dov;Nelson,MarekG.;Wang,Xingbo;Wick,MichaelM.;Zhang,Xiaoming;Lum,RobertT.[BioorganicandMedicinalChemistryLetters,1997,vol.7,#21,p.2697-2702]

203436-09-3   
Cdk2inhibitorIII 

[1]BioorganicandMedicinalChemistryLetters,1997,vol.7,p.2697-2702

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis.

Journal: The Journal of biological chemistry 20111021

Title: Global changes in and characterization of specific sites of phosphorylation in mouse and human histone H1 Isoforms upon CDK inhibitor treatment using mass spectrometry.

Journal: Journal of proteome research 20080601

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas.

Journal: Cell cycle (Georgetown, Tex.) 20071201

Title: Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes.

Journal: Journal of medicinal chemistry 20020606

Title: Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

Journal: Science (New York, N.Y.) 19980724

Title: Graub R, et al. Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. Cell Cycle. 2008 Jun 15;7(12):1795-803.

Title: Brooks EE, et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J Biol Chem. 1997 Nov 14;272(46):29207-11.

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SDS
Tags:199986-75-9 Molecular Formula|199986-75-9 MDL|199986-75-9 SMILES|199986-75-9 CVT-313