Home Amines 2450-71-7
2450-71-7,MFCD00008198
Catalog No.:AA002OA4

2450-71-7 | Propargylamine

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1g
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$6.00   $4.00
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5g
98%
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$9.00   $6.00
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10g
98%
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$15.00   $10.00
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25g
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA002OA4
Chemical Name:
Propargylamine
CAS Number:
2450-71-7
Molecular Formula:
C3H5N
Molecular Weight:
55.0785
MDL Number:
MFCD00008198
SMILES:
NCC#C
NSC Number:
80642
Properties
Properties
 
BP:
84 °C  
Form:
Liquid  
Refractive Index:
n20/D 1.449(lit.)  
Stability:
Air Sensitive  
Storage:
Light sensitive;Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
38.5  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
4  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.4  

Literature

Title: Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process.

Journal: Chemical communications (Cambridge, England) 20121104

Title: Bacitracin-conjugated superparamagnetic iron oxide nanoparticles: synthesis, characterization and antibacterial activity.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20121008

Title: A versatile method for functionalization and grafting of 2-hydroxyethyl cellulose (HEC) via Click chemistry.

Journal: Carbohydrate polymers 20121001

Title: Stereoselective intermolecular C-H amination reactions.

Journal: Chemical communications (Cambridge, England) 20120814

Title: Site-specific protein propargylation using tissue transglutaminase.

Journal: Organic & biomolecular chemistry 20120721

Title: Highly enantioselective synthesis of chiral allenes by sequential creation of stereogenic center and chirality transfer in a single pot operation.

Journal: Organic letters 20120615

Title: Site-specific modification of amino acids and peptides by aldehyde-alkyne-amine coupling under ambient aqueous conditions.

Journal: Organic letters 20120615

Title: Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

Journal: European journal of medicinal chemistry 20120601

Title: 6-Bromo-2-(diprop-2-ynyl-amino)-1H-benzo[de]isoquinoline-1,3(2H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20120601

Title: Cyclocondensation of amino-propargyl silanes.

Journal: Organic letters 20120504

Title: Gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amines: an expedient route to 3-aminoquinolines.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120427

Title: Silica based click amino stationary phase for ion chromatography and hydrophilic interaction liquid chromatography.

Journal: The Analyst 20120407

Title: Efficient iron(III)-catalyzed three-component coupling reaction of alkynes, CH2Cl2 and amines to propargylamines.

Journal: Chemical communications (Cambridge, England) 20120214

Title: Highly stereoselective synthesis of cis-β-enaminones mediated by diethyl azodicarboxylate.

Journal: Chemical communications (Cambridge, England) 20120207

Title: Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy.

Journal: Theranostics 20120101

Title: Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator.

Journal: Journal of medicinal chemistry 20111222

Title: Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs.

Journal: Journal of the American Chemical Society 20111214

Title: The marriage of organocatalysis with metal catalysis: access to multisubstituted chiral 2,5-dihydropyrroles by cascade iminium/enamine-metal cooperative catalysis.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20111209

Title: Synthesis of steroid-ferrocene conjugates of steroidal 17-carboxamides via a palladium-catalyzed aminocarbonylation--copper-catalyzed azide-alkyne cycloaddition reaction sequence.

Journal: Steroids 20111101

Title: Explaining ADAGIO: a critical review of the biological basis for the clinical effects of rasagiline.

Journal: Movement disorders : official journal of the Movement Disorder Society 20111101

Title: Propargylaminyl 3α-hy-droxy-11-oxo-18β-olean-12-en-29-oate.

Journal: Acta crystallographica. Section E, Structure reports online 20111101

Title: Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins.

Journal: Bioconjugate chemistry 20110921

Title: Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.

Journal: European journal of medicinal chemistry 20110901

Title: Propargylamine synthesis by copper-catalyzed oxidative coupling of alkynes and tertiary amine N-oxides.

Journal: The Journal of organic chemistry 20110819

Title: Gold(I) catalysts with bifunctional P, N ligands.

Journal: Inorganic chemistry 20110815

Title: Electrochemical impedance spectroscopy sensor for ascorbic acid based on copper(I) catalyzed click chemistry.

Journal: Biosensors & bioelectronics 20110715

Title: Epidermal growth factor-PEG functionalized PAMAM-pentaethylenehexamine dendron for targeted gene delivery produced by click chemistry.

Journal: Biomacromolecules 20110613

Title: Medical management of Parkinson's disease: focus on neuroprotection.

Journal: Current neuropharmacology 20110601

Title: Versatility of alkyne-modified poly(glycidyl methacrylate) layers for click reactions.

Journal: Langmuir : the ACS journal of surfaces and colloids 20110517

Title: Fluoride-cleavable, fluorescently labelled reversible terminators: synthesis and use in primer extension.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110301

Title: MAO-inhibitors in Parkinson's Disease.

Journal: Experimental neurobiology 20110301

Title: Amphiphilic amylose-g-poly(meth)acrylate copolymers through 'click' onto grafting method.

Journal: Biomacromolecules 20110214

Title: Star polymers composed entirely of amino acid building blocks: a route towards stereospecific, biodegradable and hierarchically functionalized stars.

Journal: Chemical communications (Cambridge, England) 20110128

Title: Enhanced chiral recognition by cyclodextrin dimers.

Journal: International journal of molecular sciences 20110101

Title: Controversies in neurology: why monoamine oxidase B inhibitors could be a good choice for the initial treatment of Parkinson's disease.

Journal: BMC neurology 20110101

Title: Methods for Activity Analysis of the Proteins that Regulate Histone Methylation.

Journal: Current chemical genomics 20110101

Title: Synthesis of specifically modified oligonucleotides for application in structural and functional analysis of RNA.

Journal: Journal of nucleic acids 20110101

Title: The promise of neuroprotective agents in Parkinson's disease.

Journal: Frontiers in neurology 20110101

Title: Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated alpha,beta-poly (L-aspartic acid)-camptothecin conjugate.

Journal: Colloids and surfaces. B, Biointerfaces 20101101

Title: A simple method for the preparation of propargylamines using molecular sieve modified with copper(II).

Journal: Organic & biomolecular chemistry 20101021

Title: Fine-tuning the morphology of self-assembled nanostructures of propargyl ammonium-based amphiphiles.

Journal: The journal of physical chemistry. B 20101007

Title: Merging nucleophilic and hydrogen bonding catalysis: an anion binding approach to the kinetic resolution of propargylic amines.

Journal: Journal of the American Chemical Society 20101006

Title: Highly diastereoselective synthesis of α-difluoromethyl amines from N-tert-butylsulfinyl ketimines and difluoromethyl phenyl sulfone.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20101004

Title: Mechanistic insights into the one-pot synthesis of propargylamines from terminal alkynes and amines in chlorinated solvents catalyzed by gold compounds and nanoparticles.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100809

Title: Shell-cross-linked micelles from PNIPAM-b-(PLL)2 Y-shaped miktoarm star copolymer as drug carriers.

Journal: Biomacromolecules 20100712

Title: Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.

Journal: Organic letters 20100604

Title: Why do we need multifunctional neuroprotective and neurorestorative drugs for Parkinson's and Alzheimer's diseases as disease modifying agents.

Journal: Experimental neurobiology 20100601

Title: New xanthate-based radical cyclization onto alkynes.

Journal: Chemical communications (Cambridge, England) 20100414

Title: Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors.

Journal: Journal of the American Chemical Society 20100310

Title: Chiral N-phosphonyl imine chemistry: an efficient asymmetric synthesis of chiral N-phosphonyl propargylamines.

Journal: Organic & biomolecular chemistry 20100307

Title: Copper-catalyzed enantioselective three-component synthesis of optically active propargylamines from aldehydes, amines, and aliphatic alkynes.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100222

Title: A versatile synthetic platform based on strained propargyl amines.

Journal: Angewandte Chemie (International ed. in English) 20100222

Title: TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements.

Journal: The Journal of pharmacology and experimental therapeutics 20100201

Title: Silver(I)-mediated highly enantioselective synthesis of axially chiral allenes under thermal and microwave-assisted conditions.

Journal: Chemical communications (Cambridge, England) 20100114

Title: Propargyl amine synthesis catalysed by gold and copper thin films by using microwave-assisted continuous-flow organic synthesis (MACOS).

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100104

Title: Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Native chemical ligation in the synthesis of internally modified oligonucleotide-peptide conjugates.

Journal: Biopolymers 20100101

Title: Highly selective fluorescent probe for Au3+ based on cyclization of propargylamide.

Journal: Chemical communications (Cambridge, England) 20091214

Title: Zn(II)-Catalyzed synthesis of piperidines from propargyl amines and cyclopropanes.

Journal: Organic letters 20090820

Title: Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease.

Journal: Expert review of neurotherapeutics 20090801

Title: Iron(III)-catalyzed and air-mediated tandem reaction of aldehydes, alkynes and amines: an efficient approach to substituted quinolines.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20090622

Title: Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: Three-component synthesis of N-Boc-4-iodopyrroles and sequential one-pot alkynylation.

Journal: Organic letters 20090604

Title: The 'Corey's reagent,' 3,5-di-tert-butyl-1,2-benzoquinone, as a modifying agent in the synthesis of fluorescent and double-headed nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20090501

Title: Chemoselective C-H bond activation: ligand and solvent free iron-catalyzed oxidative C-C cross-coupling of tertiary amines with terminal alkynes. Reaction scope and mechanism.

Journal: Organic letters 20090416

Title: Functionalization of macroporous organic polymer monolith based on succinimide ester reactivity for chiral capillary chromatography: a cyclodextrin click approach.

Journal: Macromolecular rapid communications 20090116

Title: Synthesis of diacetylene-containing peptide building blocks and amphiphiles, their self-assembly and topochemical polymerization in organic solvents.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

Title: Chemicals possessing a neurotrophin-like activity on dopaminergic neurons in primary culture.

Journal: PloS one 20090101

Title: Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues--allosteric inhibitors of myosin ATPase.

Journal: Angewandte Chemie (International ed. in English) 20090101

Title: Role of rasagiline in treating Parkinson's disease: Effect on disease progression.

Journal: Therapeutics and clinical risk management 20090101

Title: A novel feature of intramolecular vibrational redistribution in propargyl alcohol and propargyl amine.

Journal: The Journal of chemical physics 20080921

Title: TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity.

Journal: Journal of cardiovascular pharmacology 20080901

Title: Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries.

Journal: Natural product reports 20080801

Title: Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H(2)O(2) release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria.

Journal: Journal of bioenergetics and biomembranes 20080801

Title: A new polymorph of N-(prop-2-yn-yl)tricyclo-[3.3.1.1]decane-1-carbox-amide.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs.

Journal: Frontiers in bioscience : a journal and virtual library 20080501

Title: Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria?

Journal: Genes, brain, and behavior 20080301

Title: The phosphate site of trehalose phosphorylase from Schizophyllum commune probed by site-directed mutagenesis and chemical rescue studies.

Journal: The FEBS journal 20080301

Title: Gold-catalyzed highly enantioselective synthesis of axially chiral allenes.

Journal: Organic letters 20080207

Title: Rasagiline in treatment of Parkinson's disease.

Journal: Neuropsychiatric disease and treatment 20080201

Title: Enantioselective copper-catalyzed propargylic amination.

Journal: Angewandte Chemie (International ed. in English) 20080101

Title: A highly efficient and selective Au(I)-catalyzed tandem synthesis of diversely substituted pyrrolo[1,2-a]quinolines in aqueous media.

Journal: Angewandte Chemie (International ed. in English) 20080101

Title: Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators.

Journal: BMC neuroscience 20080101

Title: Chronic experimental diabetes accelerates urinary elimination of deprenyl and its metabolites.

Journal: The open medicinal chemistry journal 20080101

Title: Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy.

Journal: Annals of the New York Academy of Sciences 20071201

Title: Diastereoselective alkynylation of N-p-tolylsulfinylimines with aluminum acetylides.

Journal: The Journal of organic chemistry 20071012

Title: One-pot synthesis of new A-ring fused steroidal pyridines.

Journal: Steroids 20071001

Title: Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease.

Journal: Clinical therapeutics 20070901

Title: Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers.

Journal: Journal of the American Chemical Society 20070606

Title: Mitochondrial nutrition as a strategy for neuroprotection in Parkinson's disease—research focus in the department of alternative medicine and experimental therapeutics at Hokuriku University.

Journal: Evidence-based complementary and alternative medicine : eCAM 20070601

Title: Rasagiline - a novel MAO B inhibitor in Parkinson's disease therapy.

Journal: Therapeutics and clinical risk management 20070601

Title: Grafting of poly[2-(tert-butylamino)ethyl methacrylate] onto polypropylene by reactive blending and antibacterial activity of the copolymer.

Journal: Biomacromolecules 20070401

Title: A clickable inhibitor reveals context-dependent autoactivation of p90 RSK.

Journal: Nature chemical biology 20070301

Title: A RSK kinase inhibitor reporting its selectivity in vivo.

Journal: Nature chemical biology 20070301

Title: Efficient ruthenium and copper cocatalzyed five-component coupling to form dipropargyl amines under mild conditions in water.

Journal: Organic & biomolecular chemistry 20070207

Title: Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease.

Journal: Journal of neurochemistry 20070101

Title: Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.

Journal: Journal of neural transmission. Supplementum 20070101

Title: EPR studies of amine radical cations. Part 2. Thermal and photo-induced rearrangements of propargylamine and allylamine radical cations in low-temperature freon matrices.

Journal: The journal of physical chemistry. A 20061228

Title: A new consecutive three-component oxazole synthesis by an amidation-coupling-cycloisomerization (ACCI) sequence.

Journal: Chemical communications (Cambridge, England) 20061214

Title: Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil.

Journal: Neurotoxicity research 20061201

Title: Aminopropargyl derivative of terpyridine-bis(methyl-enamine) tetraacetic acid chelate of europium (Eu (TMT)-AP3): a new reagent for fluorescent labelling of proteins and peptides.

Journal: Organic & biomolecular chemistry 20061121

Title: Direct addition of alkynes to imines and related C=N electrophiles: A convenient access to propargylamines.

Journal: Chemical communications (Cambridge, England) 20061104

Title: Solid-phase synthesis of C-terminally modified peptides.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20061101

Title: Synthesis of 3-miktoarm stars and 1st generation mikto dendritic copolymers by 'living' radical polymerization and 'click' chemistry.

Journal: Journal of the American Chemical Society 20060906

Title: Asymmetric synthesis of alpha,alpha-dibranched propargylamines by acetylide additions to N-tert-butanesulfinyl ketimines.

Journal: The Journal of organic chemistry 20060901

Title: [Molecular mechanisms of the neuroprotective effect of (-)-deprenyl].

Journal: Orvosi hetilap 20060709

Title: Microwave assisted 'click' chemistry for the synthesis of multiple labeled-carbohydrate oligonucleotides on solid support.

Journal: The Journal of organic chemistry 20060609

Title: Highly enantioselective access to primary propargylamines: 4-piperidinone as a convenient protecting group.

Journal: Organic letters 20060525

Title: Practical highly enantioselective synthesis of propargylamines through a copper-catalyzed one-pot three-component condensation reaction.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060524

Title: Rationale for considering that propargylamines might be neuroprotective in Parkinson's disease.

Journal: Neurology 20060523

Title: Rasagiline: A second-generation monoamine oxidase type-B inhibitor for the treatment of Parkinson's disease.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060515

Title: Zinc- and indium-promoted conjugate addition-cyclization reactions of ethenetricarboxylates with propargylamines and alcohol: novel methylenepyrrolidine and methylenetetrahydrofuran syntheses.

Journal: The Journal of organic chemistry 20060428

Title: Gold(III) Salen complex-catalyzed synthesis of propargylamines via a three-component coupling reaction.

Journal: Organic letters 20060413

Title: A mechanism-based inactivator for histone demethylase LSD1.

Journal: Journal of the American Chemical Society 20060412

Title: Antioxidant properties of propargylamine derivatives: assessment of their ability to scavenge peroxynitrite.

Journal: The Journal of pharmacy and pharmacology 20060401

Title: Synthesis of oligonucleotides with 3'-terminal 5-(3-acylamidopropargyl)-3'-amino-2',3'-dideoxyuridine residues and their reactivity in single-nucleotide steps of chemical replication.

Journal: The Journal of organic chemistry 20060203

Title: N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060101

Title: M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease.

Journal: Journal of neural transmission. Supplementum 20060101

Title: Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety.

Journal: Journal of neural transmission. Supplementum 20060101

Title: Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions.

Journal: Drug target insights 20060101

Title: para-Hydrogenation of unsaturated moieties on poly(lysine) derived substrates for the development of novel hyperpolarized MRI contrast agents.

Journal: Organic & biomolecular chemistry 20051107

Title: Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101

Title: Clinical pharmacology of rasagiline: a novel, second-generation propargylamine for the treatment of Parkinson disease.

Journal: Journal of clinical pharmacology 20050801

Title: Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.

Journal: Annals of the New York Academy of Sciences 20050801

Title: Electrostatic stabilization in a pre-organized polar active site: the catalytic role of Lys-80 in Candida tenuis xylose reductase (AKR2B5) probed by site-directed mutagenesis and functional complementation studies.

Journal: The Biochemical journal 20050715

Title: Generation of N-heterocyclic carbenes by metal-mediated coupling of propargylamine and isocyanides.

Journal: Journal of the American Chemical Society 20050622

Title: A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors.

Journal: Organic letters 20050609

Title: Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline.

Journal: Drugs of today (Barcelona, Spain : 1998) 20050601

Title: Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives.

Journal: Brain research. Brain research reviews 20050401

Title: Determining the origin of the stabilization of DNA by 5-aminopropynylation of pyrimidines.

Journal: Biochemistry 20050329

Title: Synthesis of heterocyclic allenes via palladium-catalyzed hydride-transfer reaction of propargylic amines.

Journal: The Journal of organic chemistry 20050318

Title: An efficient synthesis of propargylamines via C-H activation catalyzed by copper(I) in ionic liquids.

Journal: Chemical communications (Cambridge, England) 20050314

Title: Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.

Journal: Mechanisms of ageing and development 20050201

Title: Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition.

Journal: Journal of neuroscience research 20050101

Title: Neuroprotection by rasagiline: a new therapeutic approach to Parkinson's disease?

Journal: CNS drug reviews 20050101

Title: CGP 3466B has no effect on disease course of (G93A) mSOD1 transgenic mice.

Journal: Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 20041201

Title: Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease.

Journal: Neurology 20041012

Title: Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20041001

Title: CuBr-catalyzed efficient alkynylation of sp3 C-H bonds adjacent to a nitrogen atom.

Journal: Journal of the American Chemical Society 20040929

Title: The mechanism of nitrogenase. Computed details of the site and geometry of binding of alkyne and alkene substrates and intermediates.

Journal: Journal of the American Chemical Society 20040929

Title: Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040901

Title: Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.

Journal: Biochemistry 20040831

Title: Localization of a catalytic intermediate bound to the FeMo-cofactor of nitrogenase.

Journal: The Journal of biological chemistry 20040813

Title: Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif.

Journal: Journal of the American Chemical Society 20040630

Title: Helical polymer carrying helical grafts from peptide-based acetylene macromonomers: synthesis.

Journal: Macromolecular bioscience 20040625

Title: Synthesis, characterisation and molecular structure of Re(III) 2-oxacyclocarbenes stabilised by a benzoyldiazenido ligand.

Journal: Dalton transactions (Cambridge, England : 2003) 20040307

Title: Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease?

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology 20040101

Title: Simultaneous analytical method for the determination of TCH346 and its four metabolites in human plasma by liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Advances in neuroprotection research for neurodegenerative diseases.

Journal: Advances in experimental medicine and biology 20040101

Title: Cytotoxicity, cytoprotection and neurotoxicity of novel deprenyl-related propargylamines, stable nitroxide free radicals, in vitro and in vivo.

Journal: In vivo (Athens, Greece) 20040101

Title: The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201

Title: Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity.

Journal: British journal of cancer 20031117

Title: L-Deprenyl as an inhibitor of menadione-induced permeability transition in liver mitochondria.

Journal: Biochemical pharmacology 20031101

Title: TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates.

Journal: Neurobiology of disease 20031101

Title: Rasagiline: an anti-Parkinson drug with neuroprotective activity.

Journal: Expert review of neurotherapeutics 20031101

Title: Inhibition of bovine plasma amine oxidase by 1,4-diamino-2-butenes and -2-butynes.

Journal: Bioorganic & medicinal chemistry 20031015

Title: The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline.

Journal: Biochemical pharmacology 20031015

Title: Enantioselective cyclization of alkene radical cations.

Journal: Organic letters 20031002

Title: Synthesis of a high-affinity fluorescent PPARgamma ligand for high-throughput fluorescence polarization assays.

Journal: Bioorganic & medicinal chemistry 20031001

Title: Three-component enantioselective synthesis of propargylamines through Zr-catalyzed additions of alkyl zinc reagents to alkynylimines.

Journal: Angewandte Chemie (International ed. in English) 20030915

Title: Sequential amination/annulation/aromatization reaction of carbonyl compounds and propargylamine: a new one-pot approach to functionalized pyridines.

Journal: The Journal of organic chemistry 20030905

Title: Enantioselective synthesis of propargylamines through Zr-catalyzed addition of mixed alkynylzinc reagents to arylimines.

Journal: Organic letters 20030904

Title: Synthesis of enantiomerically enriched propargylamines by copper-catalyzed addition of alkynes to enamines.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20030616

Title: A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20030601

Title: Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase.

Journal: Biochemical and biophysical research communications 20030516

Title: Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor.

Journal: Neuroscience letters 20030508

Title: Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030501

Title: Iterative oxazole assembly via alpha-chloroglycinates: total synthesis of (-)-muscoride A.

Journal: Angewandte Chemie (International ed. in English) 20030328

Title: Novel iminium ion equivalents prepared through C-H oxidation for the stereocontrolled synthesis of functionalized propargylic amine derivatives.

Journal: Journal of the American Chemical Society 20030226

Title: Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.

Journal: The Journal of biological chemistry 20030207

Title: Antioxidant properties of newly synthesized N-propargylamine derivatives of nitroxyl: a comparison with deprenyl.

Journal: Polish journal of pharmacology 20030101

Title: Synthesis and energy transfer efficiency of FRET terminators derived from different linkers.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Anti-apoptotic function of propargylamine inhibitors of type-B monoamine oxidase.

Journal: Inflammopharmacology 20030101

Title: Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.

Journal: Journal of medicinal chemistry 20021121

Title: Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U.

Journal: Biochemistry 20020611

Title: Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene.

Journal: Journal of the American Chemical Society 20020522

Title: Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020401

Title: Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.

Journal: Annals of the New York Academy of Sciences 20020401

Title: Transition-metal-catalyzed reactions of propargylamine with carbon dioxide and carbon disulfide.

Journal: The Journal of organic chemistry 20020111

Title: The influence of metabolism on the MAO-B inhibitory potency of selegiline.

Journal: Current medicinal chemistry 20020101

Title: Aliphatic propargylamines as symptomatic and neuroprotective treatments for neurodegenerative diseases.

Journal: Neurotoxicology and teratology 20020101

Title: Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes.

Journal: Neurotoxicology and teratology 20020101

Title: Cyclization of electron-deficient cyclopentadienone with 2-alkenyl and 2-alkynylamines via sequential pericyclic reaction pathway.

Journal: The Journal of organic chemistry 20011228

Title: Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

Journal: Cellular and molecular neurobiology 20011201

Title: Novel intramolecular rearrangement of tertiary propargylamine N-oxides.

Journal: The Journal of organic chemistry 20011019

Title: Synthesis of N-(3-arylpropyl)amino acid derivatives by Sonogashira types of reaction in aqueous media.

Journal: Organic letters 20010906

Title: Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma?

Journal: Survey of ophthalmology 20010501

Title: Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy.

Journal: Annals of the New York Academy of Sciences 20010401

Title: Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Novel propargylamine-linked nucleosides for high throughput SNP genotyping by MALDI-TOF MS.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Mechanism-based inactivation of porcine kidney diamine oxidase by 1,4-diamino-2-butene.

Journal: Biochimica et biophysica acta 19951115

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