Home Imidazoles 274-49-7
274-49-7,MFCD09263928
Catalog No.:AA007KS7

274-49-7 | Imidazo[1,5-a]pyrazine

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100mg
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$127.00   $89.00
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250mg
98%
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$193.00   $135.00
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1g
97%
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$302.00   $212.00
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10g
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$2,472.00   $1,731.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007KS7
Chemical Name:
Imidazo[1,5-a]pyrazine
CAS Number:
274-49-7
Molecular Formula:
C6H5N3
Molecular Weight:
119.1240
MDL Number:
MFCD09263928
SMILES:
n1ccn2c(c1)cnc2
NSC Number:
157973
Properties
Computed Properties
 
Complexity:
105  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
XLogP3:
0.8  

Downstream Synthesis Route
106-49-0    274-49-7   
6-(p-tolyl)imidazo1,5-apyrazine 
 
5-(p-tolyl)imidazo1,5-apyrazine 

[1]AngewandteChemie-InternationalEdition,2019,vol.58,p.15747-15751    Angew.Chem.,2019,vol.131,p.15894-15898,5

Literature

Title: Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.

Journal: Bioorganic & medicinal chemistry letters 20141001

Title: Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines.

Journal: European journal of medicinal chemistry 20110601

Title: Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.

Journal: Bioorganic & medicinal chemistry letters 20110401

Title: Synthesis of substituted imidazo[1,5-a]pyrazines via mono-, di-, and directed remote metalation strategies.

Journal: Organic letters 20091119

Title: Kinase inhibitors for the treatment of inflammatory and autoimmune disorders.

Journal: Purinergic signalling 20090301

Title: A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence.

Journal: Molecular diversity 20090201

Title: Palladium-catalyzed direct heck arylation of dual pi-deficient/pi-excessive heteroaromatics. Synthesis of C-5 arylated imidazo[1,5-a]pyrazines.

Journal: Organic letters 20080717

Title: Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.

Journal: Bioorganic & medicinal chemistry 20080201

Title: Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke.

Journal: Bioorganic & medicinal chemistry 20070115

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