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294-90-6,MFCD00066281
Catalog No.:AA002Y74

294-90-6 | 1,4,7,10-Tetraazacyclododecane

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5g
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$12.00   $8.00
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10g
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$15.00   $11.00
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25g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002Y74
Chemical Name:
1,4,7,10-Tetraazacyclododecane
CAS Number:
294-90-6
Molecular Formula:
C8H20N4
Molecular Weight:
172.2712
MDL Number:
MFCD00066281
SMILES:
N1CCNCCNCCNCC1
NSC Number:
629374
Properties
Computed Properties
 
Complexity:
65.1  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
XLogP3:
-2.4  

Literature

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Title: Molecular recognition of hydrocarbon guests by a supramolecular capsule formed by the 4:4 self-assembly of tris(Zn(2+)-cyclen) and trithiocyanurate in aqueous solution.

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Journal: Nature communications 20120417

Title: Turn-on fluorescent sensor for selective detection of Zn(2+), Cd(2+), and Hg(2+) in water.

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Journal: Bioorganic & medicinal chemistry 20120215

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Journal: Bioconjugate chemistry 20111221

Title: Positively charged lanthanide complexes with cyclen-based ligands: synthesis, solid-state and solution structure, and fluoride interaction.

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Title: Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents.

Journal: NMR in biomedicine 20111201

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Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111201

Title: 11B NMR sensing of d-block metal ions in vitro and in cells based on the carbon-boron bond cleavage of phenylboronic acid-pendant cyclen (cyclen = 1,4,7,10-tetraazacyclododecane).

Journal: Inorganic chemistry 20111121

Title: Gd(III) chelates as NMR probes of protein-protein interactions. Case study: rubredoxin and cytochrome c3.

Journal: Inorganic chemistry 20111107

Title: Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate.

Journal: Chemical communications (Cambridge, England) 20111021

Title: Selective hydrolysis of phosphate monoester by a supramolecular phosphatase formed by the self-assembly of a bis(Zn(2+)-cyclen) complex, cyanuric acid, and copper in an aqueous solution (cyclen = 1,4,7,10-tetraazacyclododecane).

Journal: Inorganic chemistry 20111017

Title: Factors influencing the DNA nuclease activity of iron, cobalt, nickel, and copper chelates.

Journal: Journal of the American Chemical Society 20111005

Title: PET imaging of CXCR4 receptors in cancer by a new optimized ligand.

Journal: ChemMedChem 20111004

Title: Metal-free cleavage efficiency toward DNA by a novel PNA analog-bridged macrocyclic polyamine.

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Title: Luminescent lanthanide-functionalized gold nanoparticles: exploiting the interaction with bovine serum albumin for potential sensing applications.

Journal: ACS nano 20110927

Title: Cationic lipids containing protonated cyclen and different hydrophobic groups linked by uracil-PNA monomer: synthesis and application for gene delivery.

Journal: European journal of medicinal chemistry 20110901

Title: N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs.

Journal: Bioorganic & medicinal chemistry 20110815

Title: Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801

Title: Cyclen-conjugated rhodamine hydroxamate as Pd(2+)-specific fluorescent chemosensor.

Journal: Chemistry, an Asian journal 20110801

Title: Conformational states of ADP ribosylation factor 1 complexed with different guanosine triphosphates as studied by 31P NMR spectroscopy.

Journal: Biochemistry 20110726

Title: Triostin A derived hybrid for simultaneous DNA binding and metal coordination.

Journal: Amino acids 20110701

Title: Sensing of biologically relevant d-metal ions using a Eu(III)-cyclen based luminescent displacement assay in aqueous pH 7.4 buffered solution.

Journal: Chemical communications (Cambridge, England) 20110628

Title: Cyclen-functionalized perylenebisimides as sensitive and selective fluorescent sensors for Pb2+ in aqueous solution.

Journal: Chemical communications (Cambridge, England) 20110621

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Journal: Chemistry & biodiversity 20110501

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Journal: Organic & biomolecular chemistry 20110407

Title: Isomeric trimethylene and ethylene pendant-armed cross-bridged tetraazamacrocycles and in vitro/in vivo comparisions of their copper(II) complexes.

Journal: Inorganic chemistry 20110404

Title: Langmuir monolayers of a cholesterol-armed cyclen complex that can control enantioselectivity of amino acid recognition by surface pressure.

Journal: Physical chemistry chemical physics : PCCP 20110321

Title: Design, synthesis and biological evaluation of choline based SPECT imaging agent: Ga(III)-DO3A-EA-Choline.

Journal: Organic & biomolecular chemistry 20110307

Title: New chelating ligands for Co(III)-based peptide-cleaving catalysts selective for pathogenic proteins of amyloidoses.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110301

Title: Cu2+-cyclen as probe to identify conformational states in guanine nucleotide binding proteins.

Journal: Journal of the American Chemical Society 20110223

Title: Challenges in optimizing a prostate carcinoma binding peptide, identified through the phage display technology.

Journal: Molecules (Basel, Switzerland) 20110214

Title: Strategies for labeling proteins with PARACEST agents.

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Title: Calcium-responsive paramagnetic CEST agents.

Journal: Bioorganic & medicinal chemistry 20110201

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Title: Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.

Journal: Dalton transactions (Cambridge, England : 2003) 20110128

Title: Zinc(II)-cyclen polyacrylamide gel electrophoresis for detection of mutations in short Ade/Thy-rich DNA fragments.

Journal: Analytical biochemistry 20110115

Title: Amino acids binding to Zn 2+-cyclen molecular receptor in aqueous solution.

Journal: Journal of molecular recognition : JMR 20110101

Title: Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease.

Journal: International journal of Alzheimer's disease 20110101

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Title: Cyclen-based cationic lipids for highly efficient gene delivery towards tumor cells.

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Journal: Nucleosides, nucleotides & nucleic acids 20110101

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Journal: PloS one 20110101

Title: TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive LipoCEST agents.

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Title: Cyclen-hybrid compound captures copper to protect INS-1 cells from islet amyloid polypeptide cytotoxicity by inhibiting and lysing effects.

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Title: Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist.

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Title: Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes.

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Title: Hydrolytic cleavage of DNA by urea-bridged macrocyclic polyamines.

Journal: European journal of medicinal chemistry 20091201

Title: Synthesis and DNA-cleavage activities of dinuclear copper(II) complexes of urea-bridged macrocyclic polyamines.

Journal: Chemistry & biodiversity 20091201

Title: Influence of cyclic polyamines on silica formation during the Stöber process.

Journal: Physical chemistry chemical physics : PCCP 20091121

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Journal: Journal of the American Chemical Society 20091021

Title: Synthesis, X-ray structure of ferrocene bearing bis(Zn-cyclen) complexes and the selective electrochemical sensing of TpT.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20091019

Title: Design and synthesis of a stable supramolecular trigonal prism formed by the self-assembly of a linear tetrakis(Zn2+-cyclen) complex and trianionic trithiocyanuric acid in aqueous solution and its complexation with DNA (cyclen = 1,4,7,10-tetraazacyclododecane).

Journal: Inorganic chemistry 20091005

Title: Metal ion-mediated nitric oxide generation from polyurethanes via covalently linked copper(II)-cyclen moieties.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials 20091001

Title: Development and physicochemical characterization of copper complexes-loaded PLGA nanoparticles.

Journal: International journal of pharmaceutics 20090911

Title: Synthesis and luminescence properties of a trinucleotide-europium(III) complex conjugate.

Journal: Organic & biomolecular chemistry 20090821

Title: Evidence for a ball-shaped cyclen cyclophane: an experimental and first principles study.

Journal: Physical chemistry chemical physics : PCCP 20090807

Title: The effect of an amino-acid bridge on binding affinity and cleavage efficiency of pyrenyl-macrocyclic polyamine conjugates toward DNA.

Journal: Chemistry & biodiversity 20090801

Title: Anion separation and preconcentration with cyclen and cyclen-resorcinarene derivatives.

Journal: Journal of chromatographic science 20090801

Title: Effects of cyclen and cyclam on zinc(II)- and copper(II)-induced amyloid beta-peptide aggregation and neurotoxicity.

Journal: Inorganic chemistry 20090706

Title: The recognition of anions using delayed lanthanide luminescence: the use of Tb(iii) based urea functionalised cyclen complexes.

Journal: Dalton transactions (Cambridge, England : 2003) 20090628

Title: Synthesis, DNA binding and photocleavage study of novel anthracene-appended macrocyclic polyamines.

Journal: Organic & biomolecular chemistry 20090607

Title: Cyclen-based side-chain homopolymer self-assembly with plasmid DNA: protection of DNA from enzymatic degradation.

Journal: Chemistry & biodiversity 20090501

Title: Photolysis of the sulfonamide bond of metal complexes of N-dansyl-1,4,7,10-tetraazacyclododecane in aqueous solution: a mechanistic study and application to the photorepair of cis,syn-cyclobutane thymine photodimer.

Journal: Chemistry, an Asian journal 20090406

Title: Synthesis of a novel linear polymer of a macrocyclic polyamine copper (II) complex and its interaction with plasmid DNA.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090401

Title: Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers.

Journal: Bioconjugate chemistry 20090401

Title: Dinuclear copper(II) complexes of macrocyclic polyamines: synthesis, characterization, and DNA cleavage.

Journal: Chemistry & biodiversity 20090401

Title: Binding of HIV-1 TAR mRNA to a peptide nucleic acid oligomer and its conjugates with metal-ion-binding multidentate ligands.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090201

Title: Novel reticular cyclen-based polymer as gene vector in DNA transfection.

Journal: Chemical biology & drug design 20090201

Title: Synthesis of 99mTc-DOTMP and its preclinical evaluation as a multidentate imaging agent for skeletal metastases.

Journal: Cancer biotherapy & radiopharmaceuticals 20090201

Title: New macrocyclic terbium(III) complex for use in RNA footprinting experiments.

Journal: Journal of the American Chemical Society 20090128

Title: Correlation of relaxivity with coordination number in six-, seven-, and eight-coordinate Mn(II) complexes of pendant-arm cyclen derivatives.

Journal: Inorganic chemistry 20090119

Title: Direct preparation of unsymmetrical difunctionalized cyclen derivatives by an Ugi multicomponent reaction.

Journal: Organic letters 20090115

Title: Proteolytic activity of Co(III) complex of 1-oxa-4,7,10-triazacyclododecane: a new catalytic center for peptide-cleavage agents.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090101

Title: Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives.

Journal: Bioorganic & medicinal chemistry letters 20090101

Title: Twelve years' experience with direct-to-consumer advertising of prescription drugs in Canada: a cautionary tale.

Journal: PloS one 20090101

Title: Zn(II)-cyclen polyacrylamide gel electrophoresis for SNP detection.

Journal: Methods in molecular biology (Clifton, N.J.) 20090101

Title: Vibration and Fluorescence Spectra of Porphyrin-Cored 2,2-Bis(methylol)-propionic Acid Dendrimers.

Journal: Sensors (Basel, Switzerland) 20090101

Title: Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents.

Journal: The Journal of biological chemistry 20081114

Title: A rhodamine-cyclen conjugate as a highly sensitive and selective fluorescent chemosensor for Hg(II).

Journal: The Journal of organic chemistry 20081107

Title: Tethered dinuclear europium(III) macrocyclic catalysts for the cleavage of RNA.

Journal: Journal of the American Chemical Society 20081105

Title: A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent.

Journal: Organic & biomolecular chemistry 20081007

Title: 64Cu-labeled 2-(diphenylphosphoryl)ethyldiphenylphosphonium cations as highly selective tumor imaging agents: effects of linkers and chelates on radiotracer biodistribution characteristics.

Journal: Bioconjugate chemistry 20081001

Title: Decomposition of dinuclear manganese complexes for the preparation of nanostructured oxide materials.

Journal: Inorganic chemistry 20080915

Title: Detection of the Gua/Cyt-to-Cyt/Gua mutation in a Gua/Cyt-lined sequence using Zn2+-cyclen polyacrylamide gel electrophoresis.

Journal: Analytical biochemistry 20080901

Title: Micelles as containers for self-assembled nanodevices: a fluorescent sensor for lipophilicity.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20080825

Title: The thulium complex of 1,4,7,10-tetrakis{[N-(1H-imidazol-2-yl)carbamoyl]methyl}-1,4,7,10-tetraazacyclododecane (dotami) as a ParaCEST contrast agent.

Journal: Chemistry & biodiversity 20080801

Title: Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4 dotp OEt).

Journal: Journal of inorganic biochemistry 20080701

Title: 19F NMR based pH probes: lanthanide(III) complexes with pH-sensitive chemical shifts.

Journal: Chemical communications (Cambridge, England) 20080614

Title: Lanthanide luminescent displacement assays: the sensing of phosphate anions using Eu(III)-cyclen-conjugated gold nanoparticles in aqueous solution.

Journal: Journal of the American Chemical Society 20080604

Title: 1,4,7,10-tetraazacyclododecane metal complexes as potent promoters of phosphodiester hydrolysis under physiological conditions.

Journal: Inorganic chemistry 20080602

Title: Polyurethane with tethered copper(II)-cyclen complex: preparation, characterization and catalytic generation of nitric oxide from S-nitrosothiols.

Journal: Biomaterials 20080601

Title: Cleavage agents for soluble oligomers of human islet amyloid polypeptide.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601

Title: Analogs of Eu3+ DOTAM-Gly-Phe-OH and Tm3+ DOTAM-Gly-Lys-OH: synthesis and magnetic properties of potential PARACEST MRI contrast agents.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Cyclen-based bismacrocycles for biological anion recognition. A potentiometric and NMR study of AMP, ADP and ATP nucleotide complexation.

Journal: Organic & biomolecular chemistry 20080521

Title: Synthesis, potentiometric, kinetic, and NMR Studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions.

Journal: Inorganic chemistry 20080505

Title: 111In-labeled galectin-3-targeting peptide as a SPECT agent for imaging breast tumors.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080501

Title: Modification of the Stöber process by a polyazamacrocycle leading to unusual core-shell silica nanoparticles.

Journal: Langmuir : the ACS journal of surfaces and colloids 20080415

Title: Design and synthesis of a caged Zn2+ probe, 8-benzenesulfonyloxy-5-N,N-dimethylaminosulfonylquinolin-2-ylmethyl-pendant 1,4,7,10-tetraazacyclododecane, and its hydrolytic uncaging upon complexation with Zn2+.

Journal: Inorganic chemistry 20080407

Title: Metal complexes as artificial proteases: toward catalytic drugs.

Journal: Current opinion in chemical biology 20080401

Title: PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.

Journal: Organic & biomolecular chemistry 20080307

Title: A novel macrocyclic polyamine cationic lipid containing an imidazolium salt group: synthesis, characterization and its transfection activity as a gene delivery vector.

Journal: Chemical biology & drug design 20080301

Title: Proteolytic activity of Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane.

Journal: Organic letters 20080207

Title: Sequence dependence in base flipping: experimental and computational studies.

Journal: Organic & biomolecular chemistry 20080207

Title: DNA cleavage by novel copper (II) complex and the role of beta-cyclodextrin in promoting cleavage.

Journal: Bioorganic & medicinal chemistry 20080201

Title: (68)Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones.

Journal: European journal of nuclear medicine and molecular imaging 20080201

Title: Nanostructured microspheres of MnO2 formed by room temperature solution processing.

Journal: Chemical communications (Cambridge, England) 20080121

Title: Antiviral properties of cobalt(III)-complexes.

Journal: Bioorganic & medicinal chemistry 20080115

Title: Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles.

Journal: Organic & biomolecular chemistry 20071121

Title: Homo- and heteropolynuclear Ni2+ and Cu2+ complexes of polytopic ligands, consisting of a tren unit substituted with three 12-membered tetraazamacrocycles.

Journal: Dalton transactions (Cambridge, England : 2003) 20071114

Title: Effective methods for the biotinylation of azamacrocycles.

Journal: The Journal of organic chemistry 20071026

Title: Near IR-emitting DNA-probes exploiting stepwise energy transfer processes.

Journal: Dalton transactions (Cambridge, England : 2003) 20071010

Title: Structural effects on the biodistribution and positron emission tomography (PET) imaging of well-defined (64)Cu-labeled nanoparticles comprised of amphiphilic block graft copolymers.

Journal: Biomacromolecules 20071001

Title: A minimalist approach to understanding the efficiency of mononuclear Zn(II) complexes as catalysts of cleavage of an RNA analog.

Journal: Dalton transactions (Cambridge, England : 2003) 20070914

Title: Synthesis and DNA-cleavage properties of metal complexes of 1,4,7,10-tetraazacyclododecane (cyclen) functionalized with a pendant benzocrown ether.

Journal: Chemistry & biodiversity 20070901

Title: One-pot preparation of surface modified boehmite nanoparticles with rare-earth cyclen complexes.

Journal: Chemical communications (Cambridge, England) 20070828

Title: Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data.

Journal: Dalton transactions (Cambridge, England : 2003) 20070714

Title: The long and short of it: the influence of N-carboxyethyl versusN-carboxymethyl pendant arms on in vitro and in vivo behavior of copper complexes of cross-bridged tetraamine macrocycles.

Journal: Dalton transactions (Cambridge, England : 2003) 20070607

Title: RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DO3A) conjugate for detecting angiogenesis biomarker alpha(v) beta3 integrin with MRT, mapping.

Journal: International journal of nanomedicine 20070601

Title: Solid-phase oligonucleotide labeling with DOTA.

Journal: Current protocols in nucleic acid chemistry 20070601

Title: Binding of nitrate to a CuII-cyclen complex bearing a ferrocenyl pendant: synthesis, solid-state X-ray structure, and solution-phase electrochemical and spectrophotometric studies.

Journal: Inorganic chemistry 20070514

Title: 1,4,7,10-tetraazacyclododecane metal complexes as potent promoters of carboxyester hydrolysis under physiological conditions.

Journal: Inorganic chemistry 20070514

Title: Results of a retrospective single institution analysis of targeted skeletal radiotherapy with (166)Holmium-DOTMP as conditioning regimen for autologous stem cell transplant for patients with multiple myeloma. Impact on transplant outcomes.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20070501

Title: A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes.

Journal: Inorganic chemistry 20070402

Title: Complexation of the triphosphate anion: tuning the structure of cyclen based macrotricycles with 1,3-dimethylbenzene and 2,6-dimethylpyridine linkers. A potentiometric and NMR study.

Journal: Dalton transactions (Cambridge, England : 2003) 20070314

Title: Recognition of thymine and related nucleosides by a Zn(II)-cyclen complex bearing a ferrocenyl pendant.

Journal: Inorganic chemistry 20070305

Title: Magnetic exchange coupling tunable by means of selective cation binding into poly(radical-armed) azacrowns.

Journal: Chemical communications (Cambridge, England) 20070207

Title: Tripodal, cooperative, and allosteric transphosphorylation metallocatalysts.

Journal: The Journal of organic chemistry 20070119

Title: pH driven self-assembly of a ternary lanthanide luminescence complex: the sensing of anions using a beta-diketonate-Eu(III) displacement assay.

Journal: Chemical communications (Cambridge, England) 20070114

Title: Copper chelation chemistry and its role in copper radiopharmaceuticals.

Journal: Current pharmaceutical design 20070101

Title: Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer.

Journal: Bioconjugate chemistry 20070101

Title: A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: new PARACEST MRI agents.

Journal: Bioconjugate chemistry 20070101

Title: New noninvasive methodology for real-time monitoring of lipid flip.

Journal: Bioconjugate chemistry 20070101

Title: Non-cytotoxic, bifunctional EuIII and TbIII luminescent macrocyclic complexes for luminescence resonant energy-transfer experiments.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: An easy route towards regioselectively difunctionalized cyclens and new cryptands.

Journal: Chemical communications (Cambridge, England) 20061228

Title: Metal-catalyzed phosphodiester cleavage: secondary 18O isotope effects as an indicator of mechanism.

Journal: Journal of the American Chemical Society 20061227

Title: Sensitized near-infrared lanthanide luminescence from Nd(III)- and Yb(III)-based cyclen-ruthenium coordination conjugates.

Journal: Inorganic chemistry 20061211

Title: A new fluorescent probe for zinc(II): an 8-hydroxy-5-N,N-dimethylaminosulfonylquinoline-pendant 1,4,7,10-tetraazacyclododecane.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20061204

Title: Mechanical control of enantioselectivity of amino acid recognition by cholesterol-armed cyclen monolayer at the air-water interface.

Journal: Journal of the American Chemical Society 20061115

Title: Efficient cycloreversion of cis,syn-thymine photodimer by a Zn2+ -1,4,7,10-tetraazacyclododecane complex bearing a lumiflavin and tryptophan by chemical reduction and photoreduction of a lumiflavin unit.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20061101

Title: Peptide-cleaving catalyst selective for melanin-concentrating hormone: Oxidative decarboxylation of N-terminal aspartate catalyzed by Co(III)cyclen.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20061001

Title: Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis; the role of basic cofactors.

Journal: Chemical communications (Cambridge, England) 20060928

Title: The conjugates of uracil-cyclen Zn(II) complexes: synthesis, characterization, and their interaction with plasmid DNA.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Influence of the 'innocent' ligands on the MLCT excited-state behavior of mono(bipyridine)ruthenium(II) complexes: a comparison of X-ray structures and 77 K luminescence properties.

Journal: Inorganic chemistry 20060807

Title: Angle-dependent electronic effects in 4,4'-bipyridine-bridged Ru3 triangle and Ru4 square complexes.

Journal: Inorganic chemistry 20060807

Title: Host-guest interaction between cyclen based macrotricyclic ligands and phosphate anions. A potentiometric investigation.

Journal: Dalton transactions (Cambridge, England : 2003) 20060728

Title: Supramolecular self-assembly of mixed f-d metal ion conjugates.

Journal: Organic letters 20060622

Title: Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: synthesis, characterization, and their interaction with plasmid DNA.

Journal: Bioorganic & medicinal chemistry 20060615

Title: Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.

Journal: Biochemical pharmacology 20060614

Title: One- and two-photon absorption and emission properties of a Zn(II) chemosensor.

Journal: The journal of physical chemistry. A 20060525

Title: Polymethacrylates with a covalently linked CuII-cyclen complex for the in situ generation of nitric oxide from nitrosothiols in blood.

Journal: Angewandte Chemie (International ed. in English) 20060421

Title: Synthesis and characterisation of bis-cyclen based dinuclear lanthanide complexes.

Journal: Organic & biomolecular chemistry 20060421

Title: 166Ho-DOTMP radiation-absorbed dose estimation for skeletal targeted radiotherapy.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20060301

Title: A europium complex that selectively stains nucleoli of cells.

Journal: Journal of the American Chemical Society 20060222

Title: Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody.

Journal: Bioconjugate chemistry 20060101

Title: Tissue pH measurement by magnetic resonance spectroscopy and imaging.

Journal: Methods in molecular medicine 20060101

Title: Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo.

Journal: Bioconjugate chemistry 20060101

Title: Conformational changes of DNA by photoirradiation of DNA-bis(Zn(II)-cyclen)-azobenzene complex.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange.

Journal: Dalton transactions (Cambridge, England : 2003) 20051221

Title: The first synthesis of chiral PNA monomer-cyclen conjugates.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20051201

Title: Positive ion pair cooperativity exhibited for the binding of phosphate under physiological conditions.

Journal: Organic & biomolecular chemistry 20051107

Title: Reliable and cost-effective screening of inherited heterozygosity by Zn2+-cyclen polyacrylamide gel electrophoresis.

Journal: Clinical chemistry 20051101

Title: Asymmetric indolylmaleimide derivatives and their complexation with zinc(II)-cyclen.

Journal: The journal of physical chemistry. A 20051027

Title: Receptor for anionic pyrene derivatives provides the basis for new biomembrane assays.

Journal: Journal of the American Chemical Society 20051026

Title: Bis-azamacrocyclic anthracene as a fluorescent chemosensor for cations in aqueous solution.

Journal: The journal of physical chemistry. B 20051020

Title: Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: synthesis, characterization, and DNA cleavage.

Journal: Bioorganic chemistry 20051001

Title: Cyclen based bis-macrocyclic ligands as phosphates receptors. A potentiometric and NMR study.

Journal: Dalton transactions (Cambridge, England : 2003) 20050921

Title: Solvent dependent conformational isomerism and ligand oxidation of novel Ru(II) cyclen complexes.

Journal: Inorganic chemistry 20050808

Title: Crystal structures of lanthanide(III) complexes with cyclen derivative bearing three acetate and one methylphosphonate pendants.

Journal: Inorganic chemistry 20050808

Title: Melanoma therapy via peptide-targeted {alpha}-radiation.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050801

Title: Responsive lanthanide luminescent cyclen complexes: from switching/sensing to supramolecular architectures.

Journal: Chemical communications (Cambridge, England) 20050707

Title: Artificial metalloprotease with active site comprising aldehyde group and Cu(II)cyclen complex.

Journal: Journal of the American Chemical Society 20050706

Title: A luminescence sensor of inositol 1,4,5-triphosphate and its model compound by ruthenium-templated assembly of a bis(Zn2+-cyclen) complex having a 2,2'-bipyridyl linker (cyclen = 1,4,7,10-tetraazacyclododecane).

Journal: Journal of the American Chemical Society 20050629

Title: Angiotensin-cleaving catalysts: conversion of N-terminal aspartate to pyruvate through oxidative decarboxylation catalyzed by Co(III)cyclen.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050601

Title: Visual sensing of Ca2+ ion via photoreaction of fluorenyl ester-armed cyclen.

Journal: Organic & biomolecular chemistry 20050507

Title: Imaging of melanoma using 64Cu- and 86Y-DOTA-ReCCMSH(Arg11), a cyclized peptide analogue of alpha-MSH.

Journal: Journal of medicinal chemistry 20050421

Title: Lewis acid properties of zinc(II) in Its cyclen complex. The structure of [Zn(cyclen)(S=C(NH2)2](ClO4)2 and the bonding of thiourea to metal ions. Some implications for zinc metalloenzymes.

Journal: Inorganic chemistry 20050418

Title: Synthesis of novel DNA cross-linking antitumour agents based on polyazamacrocycles.

Journal: Bioorganic & medicinal chemistry 20050401

Title: Design and synthesis of a novel water-soluble NMDA receptor antagonist with a 1,4,7,10-tetraazacyclododecane group.

Journal: Chemical & pharmaceutical bulletin 20050401

Title: Coumarin-based chemosensors for zinc(II): toward the determination of the design algorithm for CHEF-type and ratiometric probes.

Journal: Inorganic chemistry 20050321

Title: Cholesterol-armed cyclens for helical metal complexes offering chiral self-aggregation and sensing of amino acid anions in aqueous solutions.

Journal: The Journal of organic chemistry 20050304

Title: Peptide-cleaving catalyst selective for peptide deformylase.

Journal: Journal of the American Chemical Society 20050302

Title: Synthesis and binding properties of hybrid cyclophane-azamacrocyclic receptors.

Journal: The Journal of organic chemistry 20050107

Title: Effect on pKa of metal-bound water molecules in lanthanide ion-induced cyclen 'cavities'.

Journal: Organic letters 20041223

Title: Comparative in vivo behavior studies of cyclen-based copper-64 complexes: regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistribution.

Journal: Journal of medicinal chemistry 20041216

Title: Inside or outside a ligand cleft? Synthetic, structural, and kinetic inertness studies of zinc, cadmium, and mercury complexes of cross-bridged cyclam and cyclen.

Journal: Dalton transactions (Cambridge, England : 2003) 20041107

Title: A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs.

Journal: Journal of medicinal chemistry 20041104

Title: In vivo evaluation of copper-64-labeled monooxo-tetraazamacrocyclic ligands.

Journal: Nuclear medicine and biology 20041101

Title: Metal chelation-controlled twisted intramolecular charge transfer and its application to fluorescent sensing of metal ions and anions.

Journal: Journal of the American Chemical Society 20041020

Title: Optimization of the auxiliary ligand shell of Cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs.

Journal: Radiation research 20040901

Title: Carboxylic acid functionalized cobalt(III) cyclen complexes for catalytic hydrolysis of phosphodiester bonds.

Journal: Dalton transactions (Cambridge, England : 2003) 20040707

Title: Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex.

Journal: Dalton transactions (Cambridge, England : 2003) 20040507

Title: The structure of metallomicelles.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040419

Title: Eu(III)-cyclen-phen conjugate as a luminescent copper sensor: the formation of mixed polymetallic macrocyclic complexes in water.

Journal: Chemical communications (Cambridge, England) 20040407

Title: Synthetic creatinine receptor: imprinting of a Lewis acidic zinc(II)cyclen binding site to shape its molecular recognition selectivity.

Journal: Journal of the American Chemical Society 20040317

Title: Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes.

Journal: Journal of medicinal chemistry 20040311

Title: Zinc-nucleic acid interaction.

Journal: Chemical reviews 20040201

Title: Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20040201

Title: Evaluation of a cathepsin-cleavable peptide linked radioimmunoconjugate of a panadenocarcinoma MAb, m170, in mice and patients.

Journal: Cancer biotherapy & radiopharmaceuticals 20040201

Title: Cyclen-based phenylboronate ligands and their Eu3+ complexes for sensing glucose by MRI.

Journal: Bioconjugate chemistry 20040101

Title: Degradation of myoglobin by polymeric artificial metalloproteases containing catalytic modules with various catalytic group densities: site selectivity in peptide bond cleavage.

Journal: Journal of the American Chemical Society 20031126

Title: H+, Na+ and K+ modulated lanthanide luminescent switching of Tb(III) based cyclen aromatic diaza-crown ether conjugates in water.

Journal: Chemical communications (Cambridge, England) 20031007

Title: 166Ho-DOTMP plus melphalan followed by peripheral blood stem cell transplantation in patients with multiple myeloma: results of two phase 1/2 trials.

Journal: Blood 20031001

Title: Cyclen substitution with urea-containing dendrimeric branches. Theoretical study considering the concept of collectivity.

Journal: Journal of molecular modeling 20031001

Title: Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

Title: Molecular probe for selective detection of thiols in water of neutral pH.

Journal: Bioorganic & medicinal chemistry letters 20030804

Title: Toward protein-cleaving catalytic drugs: artificial protease selective for myoglobin.

Journal: Bioorganic & medicinal chemistry 20030703

Title: Monte Carlo simulation of a 1,4,7,10-tetraazacyclododecane/lithium complex in aqueous solution.

Journal: Inorganic chemistry 20030630

Title: Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes.

Journal: Journal of the American Chemical Society 20030402

Title: Dosimetry of high dose skeletal targeted radiotherapy (STR) with 166Ho-DOTMP.

Journal: Cancer biotherapy & radiopharmaceuticals 20030401

Title: Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers.

Journal: Chemical communications (Cambridge, England) 20030321

Title: Synthesis, characterization and coordination chemistry of the new tetraazamacrocycle 4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-bis(methanephosphonic acid monoethyl ester) dipotassium salt.

Journal: Organic & biomolecular chemistry 20030307

Title: A new zinc(II) fluorophore 2-(9-anthrylmethylamino)ethyl-appended 1,4,7,10-tetraazacyclododecane.

Journal: Inorganic chemistry 20030224

Title: Polymethylated DOTA ligands. 1. Synthesis of rigidified ligands and studies on the effects of alkyl substitution on acid-base properties and conformational mobility.

Journal: Inorganic chemistry 20021216

Title: [Supramolecular chemistry of multinuclear zinc(II) complexes in aqueous solution].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021201

Title: Protein-cleaving catalyst selective for protein substrate.

Journal: Organic letters 20021114

Title: NADH model systems functionalized with Zn(II)-cyclen as flavin binding site-structure dependence of the redox reaction within reversible aggregates.

Journal: Journal of the American Chemical Society 20021106

Title: High-dose 166Ho-DOTMP in myeloablative treatment of multiple myeloma: pharmacokinetics, biodistribution, and absorbed dose estimation.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20021001

Title: 177Lu-labeled cyclic polyaminophosphonates as potential agents for bone pain palliation.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20020801

Title: Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues.

Journal: Journal of medicinal chemistry 20020704

Title: Study of pH-dependent zinc(II)-carboxamide interactions by zinc(II)-carboxamide-appended cyclen complexes (cyclen = 1,4,7,10-tetraazacyclododecane).

Journal: Inorganic chemistry 20020617

Title: A new, facile synthesis of 1,4,7,10-tetraazacyclododecane: cyclen.

Journal: The Journal of organic chemistry 20020614

Title: Guanidine is a Zn(2+)-binding ligand at neutral pH in aqueous solution.

Journal: Journal of the American Chemical Society 20020515

Title: Highly luminescent, visible-emitting lanthanide macrocyclic chelates stable in water and derived from the cyclen framework.

Journal: Inorganic chemistry 20020506

Title: Conformational characterization of lanthanide(III)-DOTA complexes by ab initio investigation in vacuo and in aqueous solution.

Journal: Journal of the American Chemical Society 20020501

Title: A fluorescent anion sensor that works in neutral aqueous solution for bioanalytical application.

Journal: Journal of the American Chemical Society 20020417

Title: New potent agents binding to a poly(dT) sequence in double-stranded DNA: bis(Zn(2+)-cyclen) and tris(Zn(2+)-cyclen) complexes.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020401

Title: Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications.

Journal: Magnetic resonance in medicine 20020401

Title: A cuboctahedral supramolecular capsule by 4:4 self-assembly of Tris(Zn(II)-cyclen) and trianionic trithiocyanurate in aqueous solution at neutral pH (cyclen=1,4,7,10-tetraazacyclododecane).

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20020215

Title: Synthesis and NMR studies of new DOTP-like lanthanide(III) complexes containing a hydrophobic substituent on one phosphonate side arm.

Journal: Inorganic chemistry 20011217

Title: The Gd(3+) complex of a fatty acid analogue of DOTP binds to multiple albumin sites with variable water relaxivities.

Journal: Inorganic chemistry 20011217

Title: Hydrolysis of linear DNA duplex catalyzed by Co(III) complex of cyclen attached to polystyrene.

Journal: Bioorganic & medicinal chemistry letters 20011203

Title: Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20011201

Title: Ester-armed cyclens having quadruplicated helical geometry: remarkably stable and selective encapsulation of Na+ ion.

Journal: The Journal of organic chemistry 20010907

Title: Hydrolysis of plasmid DNA catalyzed by Co(III) complex of cyclen attached to polystyrene.

Journal: Bioorganic & medicinal chemistry letters 20010903

Title: Synthesis, purification and biodistribution of (205)Bi-DOTMP, visualizing bone deposition patterns with autoradiography.

Journal: Nuclear medicine and biology 20010501

Title: A double-functionalized cyclen with carbamoyl and dansyl groups (cyclen = 1,4,7,10-tetraazacyclododecane): a selective fluorescent probe for Y(3+) and La(3+).

Journal: Journal of the American Chemical Society 20010214

Title: Topologically constrained manganese(III) and iron(III) complexes of two cross-bridged tetraazamacrocycles.

Journal: Inorganic chemistry 20010129

Title: Selective cleavage of unpaired uridines with a tyrosine-cyclen conjugate.

Journal: Chembiochem : a European journal of chemical biology 20010108

Title: [DOTA-bis(amide)]lanthanide complexes: NMR evidence for differences in water-molecule exchange rates for coordination isomers.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010105

Title: 1,4,7,10-tetrakis(2,2'-bipyridyl-5-ylmethyl-bis(2,2'-bipyridine) ruthenium(II))-1,4,7,10-tetraazacyclododecane, a macrocyclic sensor for positively charged species.

Journal: Annali di chimica 20010101

Title: Differential contribution of metal complexation and dimerization to the chemotherapeutic potential of bicyclen-Zn2II complex against human immunodeficiency virus.

Journal: Biological & pharmaceutical bulletin 19960301

Title: Inhibition of human immunodeficiency virus proliferation by macrocyclic polyamines and their metal complexes.

Journal: Biological & pharmaceutical bulletin 19940201

Title: Genetic hybridization at the unlinked thy and str loci of Streptococcus.

Journal: Genetics 19751001

Title: Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684.

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Tags:294-90-6 Molecular Formula|294-90-6 MDL|294-90-6 SMILES|294-90-6 1,4,7,10-Tetraazacyclododecane |Organic_Building_Blocks