Home Other Building Blocks 380315-80-0
380315-80-0,MFCD02914760
Catalog No.:AA00C0U8

380315-80-0 | Tenovin-1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%(HPLC)
in stock  
$43.00   $30.00
- +
25mg
98%(HPLC)
in stock  
$107.00   $75.00
- +
100mg
98%(HPLC)
in stock  
$234.00   $164.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C0U8
Chemical Name:
Tenovin-1
CAS Number:
380315-80-0
Molecular Formula:
C20H23N3O2S
Molecular Weight:
369.4805
MDL Number:
MFCD02914760
SMILES:
CC(=O)Nc1ccc(cc1)NC(=S)NC(=O)c1ccc(cc1)C(C)(C)C
Properties
Properties
 
Form:
Solid  
MP:
>180°C (Subl.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
514  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
4.4  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008;13(5):454-463.

Title: Ladds MJGW, et al. Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology [published online ahead of print, 2020 Sep 8 J Biol Chem. 2020;jbc.RA119.012056.

Title: Marx C, et al. The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line. Invest New Drugs. 2017 Nov 18.

Title: Yoon KB, et al. Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells. Immune Netw. 2016 Jun;16(3):183-8.

Title: Grbesa I, et al. Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. PLoS One. 2015 Apr 27;10(4):e0124670.

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SDS
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