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483-14-7,MFCD23381071
Catalog No.:AA00DE8S

483-14-7 | rotundine

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100mg
98%
in stock  
$9.00   $6.00
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250mg
98%
in stock  
$13.00   $9.00
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1g
98%
in stock  
$29.00   $20.00
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5g
98%
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$105.00   $73.00
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25g
98%
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$358.00   $250.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DE8S
Chemical Name:
rotundine
CAS Number:
483-14-7
Molecular Formula:
C21H25NO4
Molecular Weight:
355.4275
MDL Number:
MFCD23381071
SMILES:
COc1cc2CCN3[C@H](c2cc1OC)Cc1c(C3)c(OC)c(cc1)OC
Properties
Computed Properties
 
Complexity:
475  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
4  
XLogP3:
3.2  

Literature

Title: Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice.

Journal: Chemico-biological interactions 20170425

Title: Application of an in vitro DDASS to evaluate oral absorption of two chemicals simultaneously: establishment of a level A in vitro-in vivo correlation.

Journal: Drug development and industrial pharmacy 20121101

Title: Design and evaluation of self-emulsifying drug delivery systems of Rhizoma corydalis decumbentis extracts.

Journal: Drug development and industrial pharmacy 20121001

Title: Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Differential effect of isoflurane, medetomidine, and urethane on BOLD responses to acute levo-tetrahydropalmatine in the rat.

Journal: Magnetic resonance in medicine 20120801

Title: The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats.

Journal: Pharmacology, biochemistry, and behavior 20120701

Title: High-performance liquid chromatography-time-of-flight mass spectrometry with adjustment of fragmentor voltages for rapid identification of alkaloids in rat plasma after oral administration of rhizoma Corydalis extracts.

Journal: Journal of separation science 20120701

Title: Corylucinine, a new alkaloid from Corydalis cava (Fumariaceae), and its cholinesterase activity.

Journal: Natural product communications 20120701

Title: [Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120701

Title: Comprehensive two-dimensional HepG2/cell membrane chromatography/monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines.

Journal: Journal of chromatography. A 20120615

Title: Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice.

Journal: Neuroscience bulletin 20120601

Title: Rapid determination and comparative pharmacokinetics of tetrahydropalmatine in spontaneously hypertensive rats and normotensive rats.

Journal: Biomedical chromatography : BMC 20120601

Title: Microdialysis combined with liquid chromatography-tandem mass spectrometry for the determination of levo-tetrahydropalmatine in the rat striatum.

Journal: Journal of pharmaceutical and biomedical analysis 20120501

Title: Stereoselective metabolism of tetrahydropalmatine enantiomers in rat liver microsomes.

Journal: Chirality 20120501

Title: Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants.

Journal: Journal of pharmaceutical and biomedical analysis 20120407

Title: [Tetrahydropalmatine's permeative properties of acupoint and non-acupoint transdermal administration of Baijiezi Tufang in vitro and in vivo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120401

Title: Rapid discrimination and quantification of alkaloids in Corydalis Tuber by near-infrared spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20120205

Title: The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.

Journal: Phytotherapy research : PTR 20120201

Title: Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in naïve rats detected at 9.4 T.

Journal: Magnetic resonance imaging 20120201

Title: l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction.

Journal: Future medicinal chemistry 20120201

Title: Effect of wine and vinegar processing of Rhizoma Corydalis on the tissue distribution of tetrahydropalmatine, protopine and dehydrocorydaline in rats.

Journal: Molecules (Basel, Switzerland) 20120118

Title: Current situation and perspectives of clinical study in integrative medicine in china.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats.

Journal: PloS one 20120101

Title: [Chemical constituents from Corydalis yanhusuo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

Title: Determination of L-tetrahydropalmatine in human plasma by HPLC and pharmacokinetics of its disintegrating tablets in healthy Chinese.

Journal: European journal of drug metabolism and pharmacokinetics 20111201

Title: Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20111101

Title: Antinociceptive effects of intragastric DL-tetrahydropalmatine on visceral and somatic persistent nociception and pain hypersensitivity in rats.

Journal: Pharmacology, biochemistry, and behavior 20111101

Title: Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography.

Journal: Journal of separation science 20111101

Title: [Effect of salvianolic acid B and tetrahydropalmatine on the L-type calcium channel of rat ventricular myocytes].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20111101

Title: The retardation of myometrial infiltration, reduction of uterine contractility, and alleviation of generalized hyperalgesia in mice with induced adenomyosis by levo-tetrahydropalmatine (l-THP) and andrographolide.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20111001

Title: Acetylcholinesterase inhibitors from Corydalis yanhusuo.

Journal: Natural product research 20110901

Title: Correlation between rheological properties, in vitro release, and percutaneous permeation of tetrahydropalmatine.

Journal: AAPS PharmSciTech 20110901

Title: [Study on method of Corydalis yanhusuo producing and concocting integration processing].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110901

Title: [Determination of four alkaloids in Corydalis decumbens by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat.

Journal: AANA journal 20110801

Title: Oral administration of levo-tetrahydropalmatine attenuates reinstatement of extinguished cocaine seeking by cocaine, stress or drug-associated cues in rats.

Journal: Drug and alcohol dependence 20110701

Title: [Study on the initial processing of Corydalis yanhusuo].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110701

Title: [Enhancing effect of volatile oils of rhizoma zingiberis, flos magnoliae and fructus litseae on permeation of rotundine in vitro].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

Title: Synthesis of 9-substituted derivatives of berberine as anti-HIV agents.

Journal: European journal of medicinal chemistry 20110401

Title: Pharmacokinetic study of lappaconitine hydrobromide in mice by LC-MS.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110401

Title: [Simultaneous determination of four alkaloids in Corydalis decumbens (Thunb.) Pers. by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20110201

Title: Levo-tetrahydropalmatine retards the growth of ectopic endometrial implants and alleviates generalized hyperalgesia in experimentally induced endometriosis in rats.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20110101

Title: [Inhibitory and inductive effects of (-)- and (+)-tetrahydropalmatine on CYP450 in mice].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20110101

Title: Ameliorative effects of tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-b(1) in mice kidney.

Journal: Toxicology international 20110101

Title: Novel pharmacotherapeutic treatments for cocaine addiction.

Journal: BMC medicine 20110101

Title: Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in rats.

Journal: Pharmacology, biochemistry, and behavior 20101201

Title: [Bio-activity evaluation of Qinlian Siwu decoction on inhibiting mice uterine contraction in vitro and its components analysis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

Title: Chemical fingerprint analysis of Phellodendri Amurensis Cortex by ultra performance LC/Q-TOF-MS methods combined with chemometrics.

Journal: Journal of separation science 20101101

Title: Tetrahydropalmatine inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated THP-1 cells.

Journal: Journal of medicinal food 20101001

Title: Protective effects of tetrahydropalmatine against gamma-radiation induced damage to human endothelial cells.

Journal: Life sciences 20100703

Title: Preparative separation of isoquinoline alkaloids from Stephania yunnanensis by pH-zone-refining counter-current chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100701

Title: Combined comparative and chemical proteomics on the mechanisms of levo-tetrahydropalmatine-induced antinociception in the formalin test.

Journal: Journal of proteome research 20100604

Title: Stereoselective protein binding of tetrahydropalmatine enantiomers in human plasma, HSA, and AGP, but not in rat plasma.

Journal: Chirality 20100601

Title: Affinity capillary electrophoresis coupling with partial filling technique and field-amplified sample injection for enantioseparation and determination of DL-tetrahydropalmatine.

Journal: Electrophoresis 20100601

Title: Simultaneous HPLC determination of three bioactive alkaloids in the Asian medicinal plant Stephania rotunda.

Journal: Natural product communications 20100601

Title: Correlation between synergistic action of Radix Angelica dahurica extracts on analgesic effects of Corydalis alkaloid and plasma concentration of dl-THP.

Journal: Journal of ethnopharmacology 20100504

Title: Shotgun approach based comparative proteomic analysis of levo-tetrahydropalmatine-induced apoptosis in hepatocytes.

Journal: Toxicology letters 20100415

Title: Study on the stereoselective excretion of tetrahydropalmatine enantiomers in rats and identification of in vivo metabolites by liquid chromatography-tandem mass spectrometry.

Journal: Chirality 20100301

Title: Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20100301

Title: [In vitro O-demethylation of rotundine by recombinant human CYP isoenzymes].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100301

Title: [Comparison of pharmacokinetics about ermiao capsules and ermiao pellet].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100201

Title: [Effects of four components of Rhizoma Corydalis on anoxia and peroxidation injuries in neonatal cardiomyocytes].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: Tinospora cordifolia (Willd.) Hook. f. and Thoms. (Guduchi) - validation of the Ayurvedic pharmacology through experimental and clinical studies.

Journal: International journal of Ayurveda research 20100101

Title: [Evaluation of different combinations of components of Chinese formulation shuangshentongguan by using AUC values].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090901

Title: [Chemical constituents from Corydalis yanhusuo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

Title: [Study on the influence on Rhizoma Corydalis by different harvest time and processing methods].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090701

Title: [Comparison of microwave-assisted and conventional extraction of Corydalis yanhusuo].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090701

Title: [Interaction between four herb compounds and a western drug by CYP3A4 enzyme metabolism in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

Title: [Influence of combination of extractum Angelicae Dahuricae Siccum and total alkaloids of Rhizoma Corydalis on pharmacokinetics of tetrahydropalmatine in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090601

Title: Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC.

Journal: Journal of separation science 20090501

Title: [Pharmacokinetics of three alkaloids in Huanglianjiedu decoction in rat serum by LC-MS-MS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

Title: Phytochemicals from Flemingia vestita (Fabaceae) and Stephania glabra (Menispermeaceae) alter cGMP concentration in the cestode Raillietina echinobothrida.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090401

Title: Cytotoxic activity of alkaloids isolated from Stephania rotunda [corrected].

Journal: Phytotherapy research : PTR 20090401

Title: Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20090220

Title: Levo-tetrahydropalmatine attenuates oxycodone-induced conditioned place preference in rats.

Journal: European journal of pharmacology 20090114

Title: Amphiphilic poly{[alpha-maleic anhydride-omega-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery.

Journal: International journal of nanomedicine 20090101

Title: Investigation of modulation of the alpha-2 receptor in tetrahydropalmatine (THP) analgesia in male Sprague-Dawley rats.

Journal: Journal of dietary supplements 20090101

Title: [Pharmacokinetic studies of tetrahydropalmatine and dehydrocorydaline in rat after oral administration of yanhusuo extraction by LC-MS/MS method].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081101

Title: One-step purification of palmatine and its derivative dl-tetrahydropalmatine from Enantia chlorantha using high-performance displacement chromatography.

Journal: Journal of chromatography. A 20081024

Title: Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor.

Journal: Molecules (Basel, Switzerland) 20080925

Title: Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study.

Journal: Acta pharmacologica Sinica 20080701

Title: [Studies on active ingredients in Corydalis, broken cell wall corydalis and its processed products].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

Title: Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080301

Title: Comparative studies on pharmacokinetic fates of tetrahydropalmatine enantiomers in different chemical environments in rats.

Journal: Chirality 20080201

Title: [Comparison of pharmacokinetics of tetrahydropalmatine monomer and extractive of corydalis and corydalis processed with vinegar].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071201

Title: Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.

Journal: Neuropharmacology 20071101

Title: [Optimal extraction of Dingxiang jiangqi granules].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071101

Title: Determination of tetrandrine and fangchinoline in plasma samples using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography.

Journal: Journal of chromatography. A 20070914

Title: Levo-tetrahydropalmatine attenuates cocaine self-administration and cocaine-induced reinstatement in rats.

Journal: Psychopharmacology 20070701

Title: [Effects of rotundine injection on nitric oxide synthase in tissues of different organs after ischemia/reperfusion of brain in rats].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20070601

Title: Antimalarial activity of alkaloids isolated from Stephania rotunda.

Journal: Journal of ethnopharmacology 20070530

Title: Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy.

Journal: The Journal of biological chemistry 20070518

Title: [Difference absorption of l-tetrahydropalmatine and dl-tetrahydropalmatine in intestine of rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070501

Title: Enantioseparation of tetrahydropalmatine and Tröger's base by molecularly imprinted monolith in capillary electrochromatography.

Journal: Journal of biochemical and biophysical methods 20070223

Title: Characterization of enantioselective binding of racemic natural tetrahydropalmatine to DNA by chromatographic methods.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070101

Title: Determination of DL-tetrahydropalmatine in Corydalis yanhusuo by L-tetrahydropalmatine imprinted monolithic column coupling with reversed-phase high performance liquid chromatography.

Journal: Journal of chromatography. A 20060609

Title: Evaluation of Cytotoxic Effects of Dichloromethane Extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on Cultured HeLa Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20060601

Title: Large-scale separation of alkaloids from Corydalis decumbens by pH-zone-refining counter-current chromatography.

Journal: Journal of chromatography. A 20060519

Title: Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemate.

Journal: Biopharmaceutics & drug disposition 20060401

Title: [Effects of different types and standard of processing vinegaron inherent constituents in rhizoma of Corydalis yanhusuo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060301

Title: [Protective effect of dl-tetrahydropalmatine on liver injury induced by carbon tetrachloride in mice].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060301

Title: Chiral high-performance liquid chromatographic separation of the enantiomers of tetrahydropalmatine and tetrahydroberberine, isolated from Corydalis yanhusuo.

Journal: Analytical and bioanalytical chemistry 20060201

Title: Anxiolytic-Like Effect of baicalin and its additivity with other anxiolytics.

Journal: Planta medica 20060201

Title: Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats.

Journal: Biomedical chromatography : BMC 20060101

Title: Asymmetric synthesis of tetrahydropalmatine via tandem 1,2-addition/cyclization.

Journal: The Journal of organic chemistry 20051111

Title: Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of tetrahydropalmatine enantiomers in dogs.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105

Title: [Studies on the alkaloids from herb of Corydalis adunca].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101

Title: [Stereoselective pharmacokinetics of tetrahydropalmatine in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050801

Title: [Chemical constituents from Corydalis humosa].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701

Title: [Effect of l-tetrahydropalmatine on expression of adhesion molecules induced by lipopolysaccharides in human umbilical vein endothelium cell].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

Title: Stereoselective pharmacokinetics of tetrahydropalmatine after oral administration of (-)-enantiomer and the racemate.

Journal: Chirality 20050515

Title: Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice.

Journal: Acta pharmacologica Sinica 20050501

Title: A multidisciplinary approach to the toxicologic problems associated with the use of herbal medicines.

Journal: Therapeutic drug monitoring 20050201

Title: The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber.

Journal: Biological & pharmaceutical bulletin 20040801

Title: [Resource investigation and quality evaluation on wild Corydalis yanhusuo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040501

Title: [Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040401

Title: Effects of L-tetrahydropalmatine on the expressions of bcl-2 and bax in rat after acute global cerebral ischemia and reperfusion.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

Title: [Study on extraction conditions for minute powder of processed rhizome of Corydalis with vinegar].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031001

Title: Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20030801

Title: Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site.

Journal: Planta medica 20030401

Title: The protective effect of dl-tetrahydropalmatine against the development of amygdala kindling seizures in rats.

Journal: Neuroscience letters 20020308

Title: Formation of protoberberine-type alkaloids by the tubers of somatic embryo-derived plants of Corydalis yanhusuo.

Journal: Planta medica 20011201

Title: The hypothermic effects of dl-tetrahydropalmatine in rats.

Journal: Neuroscience letters 20011123

Title: Influence of light and heat on the stability of rotundine sulfate injection.

Journal: Journal of pharmaceutical sciences 20011001

Title: DL-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.

Journal: Neuroscience letters 20010720

Title: DL-tetrahydropalmatine-produced hypotension and bradycardia in rats through the inhibition of central nervous dopaminergic mechanisms.

Journal: Pharmacology 19951001

Title: HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products.

Journal: Biochemical and biophysical research communications 19920529

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Wang JB, et al. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. Future Med Chem. 2012 Feb;4(2):177-86.

Title: Liu YL, et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice. Acta Pharmacol Sin. 2005 May;26(5):533-8.

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Tags:483-14-7 Molecular Formula|483-14-7 MDL|483-14-7 SMILES|483-14-7 rotundine