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500-65-2,MFCD00017718
Catalog No.:AA003BY2

500-65-2 | Rhapontigenin

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1mg
≥98%
in stock  
$128.00   $89.00
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100mg
>98.0%(GC)
in stock  
$355.00   $248.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003BY2
Chemical Name:
Rhapontigenin
CAS Number:
500-65-2
Molecular Formula:
C15H14O4
Molecular Weight:
258.2693
MDL Number:
MFCD00017718
SMILES:
COc1ccc(cc1O)/C=C/c1cc(O)cc(c1)O
Properties
Properties
 
Form:
Solid  
MP:
189.0 to 193.0℃  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
295  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
3.1  

Downstream Synthesis Route
10083-24-6    74-88-4    32507-66-7   
(E)-5-2-(3,4-dimethoxyphenyl)vinylbenzene-1,3-diol 
  500-65-2   
3,4,5′-trihydroxy-3′-methoxy-trans-stilbene 

[1]Patent:JP5873318,2016,B2.Locationinpatent:Paragraph0040;0052;0053;0054;0055

Literature

Title: Pharmacokinetics, bioavailability and metabolism of rhaponticin in rat plasma by UHPLC-Q-TOF/MS and UHPLC-DAD-MSn.

Journal: Bioanalysis 20120301

Title: Assessment for the light-induced cis-trans isomerization of rhapontigenin and its glucoside rhaponticin by capillary electrophoresis and spectrometric methods.

Journal: Journal of chromatography. A 20110826

Title: Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Evaluation of the antibacterial activity of rhapontigenin produced from rhapontin by biotransformation against Propionibacterium acnes.

Journal: Journal of microbiology and biotechnology 20100101

Title: Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20071101

Title: Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity.

Journal: Journal of toxicology and environmental health. Part A 20070701

Title: Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol.

Journal: Thrombosis research 20070101

Title: Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds.

Journal: The Journal of steroid biochemistry and molecular biology 20070101

Title: Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: a case of nutrigenomic.

Journal: Brain research bulletin 20061211

Title: Pharmacokinetics of selected stilbenes: rhapontigenin, piceatannol and pinosylvin in rats.

Journal: The Journal of pharmacy and pharmacology 20061101

Title: Pharmacometrics of stilbenes: seguing towards the clinic.

Journal: Current clinical pharmacology 20060101

Title: Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20050822

Title: Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.

Journal: Journal of medicinal chemistry 20030731

Title: Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010401

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