Title: Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care.
Journal: Fundamental & clinical pharmacology 20121001
Title: Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
Journal: Recent patents on drug delivery & formulation 20120801
Title: Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform.
Journal: Drug testing and analysis 20120601
Title: Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.
Journal: Fundamental & clinical pharmacology 20120201
Title: Rapid formation and resolution of cataracts following orthopedic surgery for a patient with Charcot-Marie-Tooth disease.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20120201
Title: Dermal peptide delivery using enhancer molecules and colloidal carrier systems--part I: carnosine.
Journal: Skin pharmacology and physiology 20120101
Title: Senescent phenotype of trabecular meshwork cells displays biomarkers in primary open-angle glaucoma.
Journal: Current molecular medicine 20111001
Title: Designation of imidazole-containing dipeptides as pharmacological chaperones.
Journal: Human & experimental toxicology 20110701
Title: Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.
Journal: Cell biochemistry and function 20110401
Title: Advanced drug delivery of N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine), carcinine (beta-alanylhistamine) and L-carnosine (beta-alanyl-L-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human disease management and therapy: from in vitro to the clinic.
Journal: Recent patents on drug delivery & formulation 20101101
Title: Ability of N-acetylcarnosine to protect lens crystallins from oxidation and oxidative damage by radical probe mass spectrometry (RP-MS).
Journal: Rapid communications in mass spectrometry : RCM 20101015
Title: Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy.
Journal: Frontiers in bioscience (Landmark edition) 20100601
Title: Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans.
Journal: Amino acids 20100301
Title: Therapeutic uses of drug-carrier systems for imidazole-containing dipeptide compounds that act as pharmacological chaperones and have significant impact on the treatment of chronic diseases associated with increased oxidative stress and the formation of advanced glycation end products.
Journal: Critical reviews in therapeutic drug carrier systems 20100101
Title: Current ocular drug delivery challenges for N-acetylcarnosine: novel patented routes and modes of delivery, design for enhancement of therapeutic activity and drug delivery relationships.
Journal: Recent patents on drug delivery & formulation 20091101
Title: N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage.
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090501
Title: 5-S-GAD, a novel radical scavenging compound, prevents lens opacity development.
Journal: Free radical biology & medicine 20090215
Title: N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications.
Journal: Journal of drug targeting 20090101
Title: State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
Journal: Current clinical pharmacology 20090101
Title: N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients.
Journal: American journal of therapeutics 20090101
Title: N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.
Journal: Clinical interventions in aging 20090101
Title: Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.
Journal: Drug metabolism and drug interactions 20090101
Title: Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery.
Journal: Drug development and industrial pharmacy 20081001
Title: Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia.
Journal: Bulletin of experimental biology and medicine 20080301
Title: [Search for chaperon-like anticataract drugs, the antiaggregants of lens crystallins. Communication. 1. Chaperon-like activity of N-acetyl carnosine dipeptide: in vitro study on a model of ultraviolet-induced aggregation of betaL-crystallin].
Journal: Vestnik oftalmologii 20080101
Title: [Like anticataract agents, the antiaggregants of lens crystallin. Communication 2. Study of the impact of chaperon-like (protective) activity of short-chain peptides on the rate of UV-induced aggregation of betaL-crystallins by eximer laser].
Journal: Vestnik oftalmologii 20080101
Title: [Chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 4. Study of the effect of a mixture of di- and tetrapeptides on a prolonged rat model of UV-induced cataract].
Journal: Vestnik oftalmologii 20080101
Title: Medical treatment of cataract.
Journal: Clinical & experimental ophthalmology 20070101
Title: Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products.
Journal: Life sciences 20060411
Title: Carnosine and carnosine-related antioxidants: a review.
Journal: Current medicinal chemistry 20050101
Title: Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.
Journal: Drugs in R&D 20050101
Title: Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes.
Journal: Drugs in R&D 20040101
Title: Rejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops.
Journal: Rejuvenation research 20040101
Title: Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?
Journal: Biochemical and biophysical research communications 20021115
Title: Efficacy of N-acetylcarnosine in the treatment of cataracts.
Journal: Drugs in R&D 20020101
Title: N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts.
Journal: Peptides 20010601
Title: Babizhayev MA, et al. N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts. Peptides. 2001 Jun;22(6):979-94.
Title: Dubois VD, et al. N-acetylcarnosine (NAC) drops for age-related cataract. Cochrane Database Syst Rev. 2017 Feb 28;2:CD009493.
Title: Babizhayev MA, et al. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases. Drug Metabol Drug Interact. 2009;24(2-4):275-323.
