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87096-84-2,MFCD00167607
Catalog No.:AA01E5II

87096-84-2 | NeuromedinB,Porcine

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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01E5II
Chemical Name:
NeuromedinB,Porcine
CAS Number:
87096-84-2
Molecular Formula:
C52H73N15O12S
Molecular Weight:
1132.2943
MDL Number:
MFCD00167607
SMILES:
CSCC[C@@H](C(=O)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1nc[nH]c1)NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)CC(=O)N)CC(C)C)C)Cc1ccccc1
Properties
Computed Properties
 
Complexity:
2140  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
80  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
15  
Rotatable Bond Count:
33  
XLogP3:
-1.6  

Literature

Title: G-protein coupled receptor agonists mediate Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of TOLL-like receptors and cellular signaling.

Journal: Cellular signalling 20121101

Title: Potential induced changes in neuromedin B adsorption on Ag, Au, and Cu electrodes monitored by surface-enhanced Raman scattering.

Journal: The journal of physical chemistry. B 20110908

Title: Biochemical specificity of von Economo neurons in hominoids.

Journal: American journal of human biology : the official journal of the Human Biology Council 20110101

Title: Feeding and drinking response following central administrations of bombesin-like peptides in chicks.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100801

Title: Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.

Journal: European journal of pharmacology 20100710

Title: The orientation of BN-related peptides adsorbed on SERS-active silver nanoparticles: comparison with a silver electrode surface.

Journal: The journal of physical chemistry. B 20090409

Title: Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090408

Title: Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitary.

Journal: Behavioural brain research 20090302

Title: Premature estrogen exposure alters endometrial gene expression to disrupt pregnancy in the pig.

Journal: Endocrinology 20071001

Title: Expression of neuromedin B in adipose tissue and its regulation by changes in energy balance.

Journal: Journal of molecular endocrinology 20070901

Title: Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides.

Journal: Physiology & behavior 20070516

Title: Molecular dynamics simulations of C-terminal decapeptide of gastrin-releasing peptide in DMPC bilayers: structure, stability and orientation of the peptide hormone within the bilayers.

Journal: Protein and peptide letters 20070101

Title: Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects.

Journal: Biological psychiatry 20060401

Title: Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.

Journal: European journal of pharmacology 20050509

Title: A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation.

Journal: Bioconjugate chemistry 20050101

Title: The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis.

Journal: Biochemical and biophysical research communications 20040618

Title: Thyrotropin secretagogues reduce rat pituitary neuromedin B, a local thyrotropin release inhibitor.

Journal: Experimental biology and medicine (Maywood, N.J.) 20031001

Title: Design of selective peptidomimetic agonists for the human orphan receptor BRS-3.

Journal: Journal of medicinal chemistry 20030508

Title: Pharmacological characteristics of bombesin receptor mediating hypothermia in the central nervous system of rats.

Journal: Brain research 20030418

Title: Estrogen modulates neuromedin B effects on thyrotropin and prolactin release in vitro.

Journal: Life sciences 20030110

Title: Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice.

Journal: The Journal of endocrinology 20020801

Title: Decreased marble burying behavior in female mice lacking neuromedin-B receptor (NMB-R) implies the involvement of NMB/NMB-R in 5-HT neuron function.

Journal: Brain research 20020628

Title: Rat tripeptidyl peptidase I: molecular cloning, functional expression, tissue localization and enzymatic characterization.

Journal: Biological chemistry 20011201

Title: Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368.

Journal: The Journal of biological chemistry 20010105

Title: PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.

Journal: Bioorganic & medicinal chemistry letters 19980922

Title: Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract.

Journal: Peptides 19980101

Title: Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry.

Journal: Biochemical and biophysical research communications 19950815

Title: GRP-preferring bombesin receptor subtype mediates contractile activity in cat terminal ileum.

Journal: Peptides 19940101

Title: Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord.

Journal: Biochemical and biophysical research communications 19830729

Title: Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312.

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Tags:87096-84-2 Molecular Formula|87096-84-2 MDL|87096-84-2 SMILES|87096-84-2 NeuromedinB,Porcine